Mri Methods For Imaging The Feto-Placental Vasculature And Blood

Fetal magnetic resonance imaging (MRI) in recent times has become a well-established adjunct to ultrasound (US) in routine clinical prenatal care and diagnostics. The majority of fetal MRI is restricted to T2-weighted scans, where the diagnosis is based on the appearance of normal and abnormal tissue. Although there have been many advancements in MRI and a plethora of sequences, that probe different anatomical and different physiological process, the adaptation of these in fetal imaging has been rather slow. Many of these can extract quantitative parameters that can throw light on the underlying tissue’s normal/patho-physiology. But the use of such quantitative MRI methods has been extremely limited in fetal imaging due to its unique and dynamic physiological milieu that pose several technical challenges including low signal to noise and/or resolution, artifacts associated with abdominal imaging and most importantly fetal motion. These limitations are expected to be overcome by (a) optimizing and (b) developing novel MR imaging sequences, both of which constitute the primary aim of my work. This work develops a framework that allows for vascular imaging in the fetus and placenta. This includes both qualitative vascular imaging and blood flow quantification. Towards this, three broad directions were explored (a) Moving to higher field imaging, while optimizing parameters for low energy deposition and (b) application of non-gated phase contrast MRI and (c) optimization of conventional time-of-flight angiography for fetal applications

Doctor of Philosophy

dissertationThe gold standard for evaluation of arterial disease using MR continues to be contrast-enhanced MR angiography (MRA) with gadolinium-based contrast agents (Gd-MRA). There has been a recent resurgence in interest in methods that do not rely on gadolinium for enhancement of blood vessels due to associations Gd-MRA has with nephrogenic systemic fibrosis (NSF) in patients with impaired renal function. The risk due to NSF has been shown to be minimized when selecting the appropriate contrast type and dose. Even though the risk of NSF has been shown to be minimized, demand for noncontrast MRA has continued to rise to reduce examination cost, and improve patient comfort and ability to repeat scans. Several methods have been proposed and used to perform angiography of the aorta and peripheral arteries without the use of gadolinium. These techniques have had limitations in transmit radiofrequency field (B1+) inhomogeneities, acquisition time, and specific hardware requirements, which have stunted the utility of noncontrast enhanced MRA. In this work feasibility of noncontrast (NC) MRA at 3T of the femoral arteries using dielectric padding, and using 3D radial stack of stars and compressed sensing to accelerate acquisitions in the abdomen and thorax were tested. Imaging was performed on 13 subjects in the pelvis and thighs using high permittivity padding, and 11 in the abdomen and 19 in the thorax using 3D radial stack of stars with tiny golden angle using gold standards or previously published techniques. Qualitative scores for each study were determined by radiologists who were blinded to acquisition type. Vessel conspicuity in the thigh and pelvis showed significant increase when high permittivity padding was used in the acquisition. No significant difference in image quality was observed in the abdomen and thorax when using undersampling, except for the descending aorta in thoracic imaging. All image quality scores were determined to be of diagnostic quality. In this work it is shown that NC-MRA can be improved through the use of high permittivity dielectric padding and acquisition time can be decreased through the use of 3D radial stack of stars acquisitions

Advances in Remote Sensing-based Disaster Monitoring and Assessment

Remote sensing data and techniques have been widely used for disaster monitoring and assessment. In particular, recent advances in sensor technologies and artificial intelligence-based modeling are very promising for disaster monitoring and readying responses aimed at reducing the damage caused by disasters. This book contains eleven scientific papers that have studied novel approaches applied to a range of natural disasters such as forest fire, urban land subsidence, flood, and tropical cyclones

Frequency Diverse Array Radar: Signal Characterization and Measurement Accuracy

Radar systems provide an important remote sensing capability, and are crucial to the layered sensing vision; a concept of operation that aims to apply the right number of the right types of sensors, in the right places, at the right times for superior battle space situational awareness. The layered sensing vision poses a range of technical challenges, including radar, that are yet to be addressed. To address the radar-specific design challenges, the research community responded with waveform diversity; a relatively new field of study which aims reduce the cost of remote sensing while improving performance. Early work suggests that the frequency diverse array radar may be able to perform several remote sensing missions simultaneously without sacrificing performance. With few techniques available for modeling and characterizing the frequency diverse array, this research aims to specify, validate and characterize a waveform diverse signal model that can be used to model a variety of traditional and contemporary radar configurations, including frequency diverse array radars. To meet the aim of the research, a generalized radar array signal model is specified. A representative hardware system is built to generate the arbitrary radar signals, then the measured and simulated signals are compared to validate the model. Using the generalized model, expressions for the average transmit signal power, angular resolution, and the ambiguity function are also derived. The range, velocity and direction-of-arrival measurement accuracies for a set of signal configurations are evaluated to determine whether the configuration improves fundamental measurement accuracy

Geodetic monitoring of complex shaped infrastructures using Ground-Based InSAR

In the context of climate change, alternatives to fossil energies need to be used as much as possible to produce electricity. Hydroelectric power generation through the utilisation of dams stands out as an exemplar of highly effective methodologies in this endeavour. Various monitoring sensors can be installed with different characteristics w.r.t. spatial resolution, temporal resolution and accuracy to assess their safe usage. Among the array of techniques available, it is noteworthy that ground-based synthetic aperture radar (GB-SAR) has not yet been widely adopted for this purpose. Despite its remarkable equilibrium between the aforementioned attributes, its sensitivity to atmospheric disruptions, specific acquisition geometry, and the requisite for phase unwrapping collectively contribute to constraining its usage. Several processing strategies are developed in this thesis to capitalise on all the opportunities of GB-SAR systems, such as continuous, flexible and autonomous observation combined with high resolutions and accuracy. The first challenge that needs to be solved is to accurately localise and estimate the azimuth of the GB-SAR to improve the geocoding of the image in the subsequent step. A ray tracing algorithm and tomographic techniques are used to recover these external parameters of the sensors. The introduction of corner reflectors for validation purposes confirms a significant error reduction. However, for the subsequent geocoding, challenges persist in scenarios involving vertical structures due to foreshortening and layover, which notably compromise the geocoding quality of the observed points. These issues arise when multiple points at varying elevations are encapsulated within a singular resolution cell, posing difficulties in pinpointing the precise location of the scattering point responsible for signal return. To surmount these hurdles, a Bayesian approach grounded in intensity models is formulated, offering a tool to enhance the accuracy of the geocoding process. The validation is assessed on a dam in the black forest in Germany, characterised by a very specific structure. The second part of this thesis is focused on the feasibility of using GB-SAR systems for long-term geodetic monitoring of large structures. A first assessment is made by testing large temporal baselines between acquisitions for epoch-wise monitoring. Due to large displacements, the phase unwrapping can not recover all the information. An improvement is made by adapting the geometry of the signal processing with the principal component analysis. The main case study consists of several campaigns from different stations at Enguri Dam in Georgia. The consistency of the estimated displacement map is assessed by comparing it to a numerical model calibrated on the plumblines data. It exhibits a strong agreement between the two results and comforts the usage of GB-SAR for epoch-wise monitoring, as it can measure several thousand points on the dam. It also exhibits the possibility of detecting local anomalies in the numerical model. Finally, the instrument has been installed for continuous monitoring for over two years at Enguri Dam. An adequate flowchart is developed to eliminate the drift happening with classical interferometric algorithms to achieve the accuracy required for geodetic monitoring. The analysis of the obtained time series confirms a very plausible result with classical parametric models of dam deformations. Moreover, the results of this processing strategy are also confronted with the numerical model and demonstrate a high consistency. The final comforting result is the comparison of the GB-SAR time series with the output from four GNSS stations installed on the dam crest. The developed algorithms and methods increase the capabilities of the GB-SAR for dam monitoring in different configurations. It can be a valuable and precious supplement to other classical sensors for long-term geodetic observation purposes as well as short-term monitoring in cases of particular dam operations

Terahertz Micro-Doppler Radar for Detection and Characterization of Multicopters

abstract: The micromotions (e.g. vibration, rotation, etc.,) of a target induce time-varying frequency modulations on the reflected signal, called the micro-Doppler modulations. Micro-Doppler modulations are target specific and may contain information needed to detect and characterize the target. Thus, unlike conventional Doppler radars, Fourier transform cannot be used for the analysis of these time dependent frequency modulations. While Doppler radars can detect the presence of a target and deduce if it is approaching or receding from the radar location, they cannot identify the target. Meaning, for a Doppler radar, a small commercial aircraft and a fighter plane when gliding at the same velocity exhibit similar radar signature. However, using a micro-Doppler radar, the time dependent frequency variations caused by the vibrational and rotational micromotions of the two aircrafts can be captured and analyzed to discern between them. Similarly, micro-Doppler signature can be used to distinguish a multicopter from a bird, a quadcopter from a hexacopter or a octacopter, a bus from a car or a truck and even one person from another. In all these scenarios, joint time-frequency transforms must be employed for the analysis of micro-Doppler variations, in order to extract the targets’ features. Due to ample bandwidth, THz radiation provides richer radar signals than the microwave systems. Thus, a Terahertz (THz) micro-Doppler radar is developed in this work for the detection and characterization of the micro-Doppler signatures of quadcopters. The radar is implemented as a continuous-wave (CW) radar in monostatic configuration and operates at a low-THz frequency of 270 GHz. A linear time-frequency transform, the short-time Fourier transform (STFT) is used for the analysis the micro-Doppler signature. The designed radar has been built and measurements are carried out using a quadcopter to detect the micro-Doppler modulations caused by the rotation of its propellers. The spectrograms are obtained for a quadcopter hovering in front of the radar and analysis methods are developed for characterizing the frequency variations caused by the rotational and vibrational micromotions of the quadcopter. The proposed method can be effective for distinguishing the quadcopters from other flying targets like birds which lack the rotational micromotions.Dissertation/ThesisMasters Thesis Electrical Engineering 201

Computational intelligence techniques for HVAC systems: a review

Buildings are responsible for 40% of global energy use and contribute towards 30% of the total CO2 emissions. The drive to reduce energy use and associated greenhouse gas emissions from buildings has acted as a catalyst in the development of advanced computational methods for energy efficient design, management and control of buildings and systems. Heating, ventilation and air conditioning (HVAC) systems are the major source of energy consumption in buildings and an ideal candidate for substantial reductions in energy demand. Significant advances have been made in the past decades on the application of computational intelligence (CI) techniques for HVAC design, control, management, optimization, and fault detection and diagnosis. This article presents a comprehensive and critical review on the theory and applications of CI techniques for prediction, optimization, control and diagnosis of HVAC systems.The analysis of trends reveals the minimization of energy consumption was the key optimization objective in the reviewed research, closely followed by the optimization of thermal comfort, indoor air quality and occupant preferences. Hardcoded Matlab program was the most widely used simulation tool, followed by TRNSYS, EnergyPlus, DOE–2, HVACSim+ and ESP–r. Metaheuristic algorithms were the preferred CI method for solving HVAC related problems and in particular genetic algorithms were applied in most of the studies. Despite the low number of studies focussing on MAS, as compared to the other CI techniques, interest in the technique is increasing due to their ability of dividing and conquering an HVAC optimization problem with enhanced overall performance. The paper also identifies prospective future advancements and research directions

4D Flow cardiovascular magnetic resonance consensus statement: 2023 update

Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 '4D Flow CMR Consensus Statement'. We elaborate on 4D Flow CMR sequence options and imaging considerations. The document aims to assist centers starting out with 4D Flow CMR of the heart and great vessels with advice on acquisition parameters, post-processing workflows and integration into clinical practice. Furthermore, we define minimum quality assurance and validation standards for clinical centers. We also address the challenges faced in quality assurance and validation in the research setting. We also include a checklist for recommended publication standards, specifically for 4D Flow CMR. Finally, we discuss the current limitations and the future of 4D Flow CMR. This updated consensus paper will further facilitate widespread adoption of 4D Flow CMR in the clinical workflow across the globe and aid consistently high-quality publication standards