6,802 research outputs found
Graph-Based Decoding Model for Functional Alignment of Unaligned fMRI Data
Aggregating multi-subject functional magnetic resonance imaging (fMRI) data
is indispensable for generating valid and general inferences from patterns
distributed across human brains. The disparities in anatomical structures and
functional topographies of human brains warrant aligning fMRI data across
subjects. However, the existing functional alignment methods cannot handle well
various kinds of fMRI datasets today, especially when they are not
temporally-aligned, i.e., some of the subjects probably lack the responses to
some stimuli, or different subjects might follow different sequences of
stimuli. In this paper, a cross-subject graph that depicts the
(dis)similarities between samples across subjects is used as a priori for
developing a more flexible framework that suits an assortment of fMRI datasets.
However, the high dimension of fMRI data and the use of multiple subjects makes
the crude framework time-consuming or unpractical. To address this issue, we
further regularize the framework, so that a novel feasible kernel-based
optimization, which permits nonlinear feature extraction, could be
theoretically developed. Specifically, a low-dimension assumption is imposed on
each new feature space to avoid overfitting caused by the
highspatial-low-temporal resolution of fMRI data. Experimental results on five
datasets suggest that the proposed method is not only superior to several
state-of-the-art methods on temporally-aligned fMRI data, but also suitable for
dealing `with temporally-unaligned fMRI data.Comment: 17 pages, 10 figures, Proceedings of the Association for the
Advancement of Artificial Intelligence (AAAI-20
Construction of embedded fMRI resting state functional connectivity networks using manifold learning
We construct embedded functional connectivity networks (FCN) from benchmark
resting-state functional magnetic resonance imaging (rsfMRI) data acquired from
patients with schizophrenia and healthy controls based on linear and nonlinear
manifold learning algorithms, namely, Multidimensional Scaling (MDS), Isometric
Feature Mapping (ISOMAP) and Diffusion Maps. Furthermore, based on key global
graph-theoretical properties of the embedded FCN, we compare their
classification potential using machine learning techniques. We also assess the
performance of two metrics that are widely used for the construction of FCN
from fMRI, namely the Euclidean distance and the lagged cross-correlation
metric. We show that the FCN constructed with Diffusion Maps and the lagged
cross-correlation metric outperform the other combinations
Spatio-temporal wavelet regularization for parallel MRI reconstruction: application to functional MRI
Parallel MRI is a fast imaging technique that enables the acquisition of
highly resolved images in space or/and in time. The performance of parallel
imaging strongly depends on the reconstruction algorithm, which can proceed
either in the original k-space (GRAPPA, SMASH) or in the image domain
(SENSE-like methods). To improve the performance of the widely used SENSE
algorithm, 2D- or slice-specific regularization in the wavelet domain has been
deeply investigated. In this paper, we extend this approach using 3D-wavelet
representations in order to handle all slices together and address
reconstruction artifacts which propagate across adjacent slices. The gain
induced by such extension (3D-Unconstrained Wavelet Regularized -SENSE:
3D-UWR-SENSE) is validated on anatomical image reconstruction where no temporal
acquisition is considered. Another important extension accounts for temporal
correlations that exist between successive scans in functional MRI (fMRI). In
addition to the case of 2D+t acquisition schemes addressed by some other
methods like kt-FOCUSS, our approach allows us to deal with 3D+t acquisition
schemes which are widely used in neuroimaging. The resulting 3D-UWR-SENSE and
4D-UWR-SENSE reconstruction schemes are fully unsupervised in the sense that
all regularization parameters are estimated in the maximum likelihood sense on
a reference scan. The gain induced by such extensions is illustrated on both
anatomical and functional image reconstruction, and also measured in terms of
statistical sensitivity for the 4D-UWR-SENSE approach during a fast
event-related fMRI protocol. Our 4D-UWR-SENSE algorithm outperforms the SENSE
reconstruction at the subject and group levels (15 subjects) for different
contrasts of interest (eg, motor or computation tasks) and using different
parallel acceleration factors (R=2 and R=4) on 2x2x3mm3 EPI images.Comment: arXiv admin note: substantial text overlap with arXiv:1103.353
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