Visualization and Localization of Interventional Devices with MRI by Susceptibility Mapping

Recently, interventional procedures can be performed with the visual assistance of MRI. However, the devices used in these procedures, such as brachytherapy seeds, biopsy needles, markers, and stents, have a large magnetic susceptibility that leads to severe signal loss and distortion in the MRI images and degrades the accuracy of the localization. Right now, there is no effective way to correctly identify, localize and visualize these interventional devices in MRI images. In this dissertation, we proposed a method to improve the accuracy of localization and visualization by generating positive contrast of the interventional devices using a regularized L1 minimization algorithm. Specifically, the spin-echo sequence with a shifted 180-degree pulse is used to acquire high SNR data. A short shift time is used to avoid severe phase wrap. A phase unwrapping method based on Markov Random Field using Highest-Confidence-First algorithm is proposed to unwrap the phase image. Then the phase images with different shifted time are used to calculate the field map. Next, L1 regularized deconvolution is performed to calculate the susceptibility map. With much higher susceptibility of the interventional devices than the background tissue, the interventional devices show positive-contrast in the susceptibility image. Computer simulations were performed to study the effect of the signal-to-noise ratio, resolution, orientation and size of the interventional devices on the accuracy of the results. Experiments were performed using gelatin and tissue phantom with brachytherapy seeds, gelatin phantoms with platinum wires, and water phantom with titanium needles. The results show that the proposed method provide positive contrast images of these interventional devices, differentiate them from other structures in the MRI images, and improves the visualization and localization of the devices

Novel block-based motion estimation and segmentation for video coding

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Contributions to IEEE 802.11-based long range communications

The most essential part of the Internet of Things (IoT) infrastructure is the wireless communication system that acts as a bridge for the delivery of data and control messages between the connected things and the Internet. Since the conception of the IoT, a large number of promising applications and technologies have been developed, which will change different aspects in our daily life. However, the existing wireless technologies lack the ability to support a huge amount of data exchange from many battery-driven devices, spread over a wide area. In order to support the IoT paradigm, IEEE 802.11ah is an Internet of Things enabling technology, where the efficient management of thousands of devices is a key function. This is one of the most promising and appealing standards, which aims to bridge the gap between traditional mobile networks and the demands of the IoT. To this aim, IEEE 802.11ah provides the Restricted Access Window (RAW) mechanism, which reduces contention by enabling transmissions for small groups of stations. Optimal grouping of RAW stations requires an evaluation of many possible configurations. In this thesis, we first discuss the main PHY and MAC layer amendments proposed for IEEE 802.11ah. Furthermore, we investigate the operability of IEEE 802.11ah as a backhaul link to connect devices over possibly long distances. Additionally, we compare the aforementioned standard with previous notable IEEE 802.11 amendments (i.e. IEEE 802.11n and IEEE 802.11ac) in terms of throughput (with and without frame aggregation) by utilizing the most robust modulation schemes. The results show an improved performance of IEEE 802.11ah (in terms of power received at long range while experiencing different packet error rates) as compared to previous IEEE 802.11 standards. Additionally, we expose the capabilities of future IEEE 802.11ah in supporting different IoT applications. In addition, we provide a brief overview of the technology contenders that are competing to cover the IoT communications framework. Numerical results are presented showing how the future IEEE 802.11ah specification offers the features required by IoT communications, thus putting forward IEEE 802.11ah as a technology to cater the needs of the Internet of Things paradigm. Finally, we propose an analytical model (named e-model) that provides an evaluation of the RAW onfiguration performance, allowing a fast adaptation of RAW grouping policies, in accordance to varying channel conditions. We base the e-model in known saturation models, which we adapted to include the IEEE 802.11ah’s PHY and MAC layer modifications and to support different bit rate and packet sizes. As a proof of concept, we use the proposed model to compare the performance of different grouping strategies,showing that the e-model is a useful analysis tool in RAW-enabled scenarios. We validate the model with existing IEEE 802.11ah implementation for ns-3.La clave del concepto Internet de las cosas (IoT) es que utiliza un sistema de comunicación inalámbrica, el cual actúa como puente para la entrega de datos y mensajes de control entre las "cosas" conectadas y el Internet. Desde la concepción del IoT, se han desarrollado gran cantidad de aplicaciones y tecnologías prometedoras que cambiarán distintos aspectos de nuestra vida diaria.Sin embargo, las tecnologías de redes computacionales inalámbricas existentes carecen de la capacidad de soportar las características del IoT, como las grandes cantidades de envío y recepción de datos desde múltiples dispositivos distribuidos en un área amplia, donde los dispositivos IoT funcionan con baterías. Para respaldar el paradigma del IoT, IEEE 802.11ah, la cual es una tecnología habilitadora del Internet de las cosas, para el cual la gestión eficiente de miles de dispositivos es una función clave. IEEE 802.11ah es uno de los estándares más prometedores y atractivos, desde su concepción orientada para IoT, su objetivo principal es cerrar la brecha entre las redes móviles tradicionales y la demandada por el IoT. Con este objetivo en mente, IEEE 802.11ah incluye entre sus características especificas el mecanismo de ventana de acceso restringido (RAW, por sus siglas en ingles), el cual define un nuevo período de acceso al canal libre de contención, reduciendo la misma al permitir transmisiones para pequeños grupos de estaciones. Nótese que para obtener una agrupación óptima de estaciones RAW, se requiere una evaluación de las distintas configuraciones posibles. En esta tesis, primero discutimos las principales mejoras de las capas PHY y MAC propuestas para IEEE 802.11ah. Además, investigamos la operatividad de IEEE 802.11ah como enlace de backhaul para conectar dispositivos a distancias largas. También, comparamos el estándar antes mencionado con las notables especificaciones IEEE 802.11 anteriores (es decir, IEEE 802.11n y IEEE 802.11ac), en términos de rendimiento (incluyendo y excluyendo la agregación de tramas de datos) y utilizando los esquemas de modulación más robustos. Los resultados muestran mejores resultados en cuanto al rendimiento de IEEE 802.11ah (en términos de potencia recibida a largo alcance, mientras se experimentan diferentes tasas de error de paquetes de datos) en comparación con los estándares IEEE 802.11 anteriores.Además, exponemos las capacidades de IEEE 802.11ah para admitir diferentes aplicaciones de IoT. A su vez, proporcionamos una descripción general de los competidores tecnológicos, los cuales contienden para cubrir el marco de comunicaciones IoT. También se presentan resultados numéricos que muestran cómo la especificación IEEE 802.11ah ofrece las características requeridas por las comunicaciones IoT, presentando así a IEEE 802.11ah como una tecnología que puede satisfacer las necesidades del paradigma de Internet de las cosas.Finalmente, proponemos un modelo analítico (denominado e-model) que proporciona una evaluación del rendimiento utilizando la característica RAW con múltiples configuraciones, el cual permite una rápida adaptación de las políticas de agrupación RAW, de acuerdo con las diferentes condiciones del canal de comunicación. Basamos el e-model en modelos de saturación conocidos, que adaptamos para incluir las modificaciones de la capa MAC y PHY de IEEE 802.11ah y para poder admitir diferentes velocidades de transmisión de datos y tamaños de paquetes. Como prueba de concepto, utilizamos el modelo propuesto para comparar el desempeño de diferentes estrategias de agrupación, mostrando que el e-model es una herramienta de análisis útil en escenarios habilitados para RAW. Cabe mencionar que también validamos el modelo con la implementación IEEE 802.11ah existente para ns-3

Motion and emotion : Semantic knowledge for hollywood film indexing

Ph.DDOCTOR OF PHILOSOPH

Machine vision techniques for inspection of dry-fibre composite preforms in the aerospace industry

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis presents the results of a three year investigation into machine vision techniques for in-process automated inspection of dry-fibre composite preforms. Efficient texture analysis based techniques have been developed, tested, and implemented in a prototype robotic assembly cell. Industrial constraints have been considered in the development of all the algorithms described. A single channel texture analysis model is described which can successfully segment images containing only a few textures. The model is based on convolution of the image with small kernels optimised for the task, and is elegant in the sense that it is computationally simple and easily realisable in low cost hardware. A new convolution kernel optimisation algorithm is described. It is demonstrated that convolution kernels can also be optimised to perform as edge operators in simple textured images. A novel boundary refinement algorithm is described which reduces the inspection errors inherent in texture based boundary estimates. The algorithm takes the form of a local search, using the texture estimate as a guiding template, and selects edge points by maximising a merit function. Optimum parameters for the merit function are obtained using multiple training images in conjunction with simple function optimisation algorithms.This study is funded by the Engineering and Physical Sciences Research Council (EPSRC) and Dowty Aerospace Propellers Ltd

Design and optimization of QoS-based medium access control protocols for next-generation wireless LANs

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In recent years, there have been tremendous advances in wireless & mobile communications, including wireless radio techniques, networking protocols, and mobile devices. It is expected that different broadband wireless access technologies, e.g., WiFi (IEEE 802.11) and WiMAX (IEEE 802.16) will coexist in the future. In the meantime, multimedia applications have experienced an explosive growth with increasing user demands. Nowadays, people expect to receive high-speed video, audio, voice and web services even when being mobile. The key question that needs to be answered, then, is how do we ensure that users always have the "best" network performance with the "lowest" costs in such complicated situations? The latest IEEE 802.11n standards attains rates of more than 100 Mbps by introducing innovative enhancements at the PHY and MAC layer, e.g. MIMO and Frame Aggregation, respectively. However, in this thesis we demonstrate that frame aggregation's performance adheres due to the EDCA scheduler's priority mechanism and consequently resulting in the network's poor overall performance. Short waiting times for high priority flows into the aggregation queue resolves to poor channel utilization. A Delayed Channel Access algorithm was designed to intentionally postpone the channel access procedure so that the number of packets in a formed frame can be increased and so will the network's overall performance. However, in some cases, the DCA algorithm has a negative impact on the applications that utilize the TCP protocol, especially the when small TCP window sizes are engaged. So, the TCP process starts to refrain from sending data due to delayed acknowledgements and the overall throughput drops. In this thesis, we address the above issues by firstly demonstrating the potential performance benefits of frame aggregation over the next generation wireless networks. The efficiency and behaviour of frame aggregation within a single queue, are mathematically analysed with the aid of a M=G[a;b]=1=K model. Results show that a trade-off choice has to be taken into account over minimizing the waiting time or maximizing utilization. We also point out that there isn't an optimum batch collection rule which can be assumed as generally valid but individual cases have to be considered separately. Secondly, we demonstrate through extensive simulations that by introducing a method, the DCA algorithm, which dynamically determines and adapts batch collections based upon the traffic's characteristics, QoS requirements and server's maximum capacity, also improves e ciency. Thirdly, it is important to understand the behaviour of the TCP ows over the WLAN and the influence that DCA has over the degrading performance of the TCP protocol. We investigate the cause of the problem and provide the foundations of designing and implementing possible solutions. Fourthly, we introduce two innovative proposals, one amendment and one extension to the original DCA algorithm, called Adaptive DCA and Selective DCA, respectively. Both solutions have been implemented in OPNET and extensive simulation runs over a wide set of scenarios show their effectiveness over the network's overall performance, each in its own way.This study was supported by the Engineering and Physical Sciences Research Council (EPSRC)

Rhythmic modulation of transcriptional burst frequency in circadian gene promoters

Isogenic cells sharing a common environment present a large degree of heterogeneity in gene expression, and stochasticity inherent to transcription substantially participates in this cell-to-cell variability. Notably, a majority of mammalian genes are transcribed during short periods termed transcription bursts followed by longer periods of transcriptional inactivity. Interestingly, genes display variability in the frequencies and sizes of their bursts, implying that different regulatory mechanisms actively participate in shaping gene-specific bursting signatures. However, the nature of these molecular mechanisms and their precise contribution to transcriptional bursting remains elusive. In this work, we used a short-lived luciferase reporter under the control of a Bmal1 circadian promoter stably inserted into the genome of NIH-3T3 cultured fibroblasts to quantify its transcriptional bursting along the circadian cycle and at three different reporter integration sites. By recording dynamic variations of the luminescence signal at the single-cell level and counting individual transcripts using smRNA-FISH at specific time-points, we could infer the transcriptional bursting parameters characteristic of these conditions using a telegraph (on-off) model of gene expression. We observed that while the integration site-specific differences in expression levels mainly arose from burst size dissimilarities, the burst frequency predominantly modulated the temporal variations in expression of Bmal1 over the circadian cycle. Thus, both parameters are uncoupled and can be independently modulated to regulate expression levels. By focusing on the molecular origins of bursting, we found that the rhythmic circadian modulation of burst frequencies depended on the presence of ROR responsive elements (ROREs) on Bmal1 promoter. These DNA motifs recruit the REV-ERBs repressors involved in the rhythmic regulation of the histone acetylation state at target promoters. Indeed, the H3K27ac profile in the Bmal1 promoter corresponded to that of its burst frequency. More generally, higher histone acetylation levels were observed during Bmal1 circadian peaks of expression, while H3K27ac signal did not vary between clones harboring different reporter integration sites. Similar properties were observed on other rhythmically expressed genes: despite variability in promoter motifs and expression phases, endogenous circadian genes displaying rhythmic variations in their promoter acetylation state also modulated their burst frequencies over the circadian period. By inferring the transcriptional bursting parameters of non-circadian genes using smRNA-FISH datasets, we also observed significant correlations between histone acetylation signal around promoters and the burst frequency. In conclusion, this study identified an association between the burst frequency and the histone acetylation state of promoters. While the molecular mechanisms behind this association remain elusive, it could be related to the facilitated binding of transcription regulators upon histone acetylation-mediated chromatin loosening. In this thesis we clarified how transcription of circadian genes is rhythmically modulated, and we further elucidated the link between molecular events and transcriptional bursting, with particular focus on histone acetylation

Proceedings of the Third Edition of the Annual Conference on Wireless On-demand Network Systems and Services (WONS 2006)

Ce fichier regroupe en un seul documents l'ensemble des articles accéptés pour la conférences WONS2006/http://citi.insa-lyon.fr/wons2006/index.htmlThis year, 56 papers were submitted. From the Open Call submissions we accepted 16 papers as full papers (up to 12 pages) and 8 papers as short papers (up to 6 pages). All the accepted papers will be presented orally in the Workshop sessions. More precisely, the selected papers have been organized in 7 session: Channel access and scheduling, Energy-aware Protocols, QoS in Mobile Ad-Hoc networks, Multihop Performance Issues, Wireless Internet, Applications and finally Security Issues. The papers (and authors) come from all parts of the world, confirming the international stature of this Workshop. The majority of the contributions are from Europe (France, Germany, Greece, Italy, Netherlands, Norway, Switzerland, UK). However, a significant number is from Australia, Brazil, Canada, Iran, Korea and USA. The proceedings also include two invited papers. We take this opportunity to thank all the authors who submitted their papers to WONS 2006. You helped make this event again a success

Dichte Objektsegmentierung in Stereobildfolgen

Die in dieser Arbeit vorgestellte Szenensegmentierung zerlegt eine Stereobildsequenz in eine Menge von Bildbereichen, die vom Menschen eindeutig als unabhängig bewegte Verkehrsobjekte interpretierbar sind. Eine Besonderheit des Verfahrens ist die Tatsache, dass die einzelnen Teilaufgaben der dreidimensionalen Rekonstruktion, Bewegungsschätzung und Segmentierung dabei in einem gemeinsamen Modell beschrieben und in verzahnter Reihenfolge gelöst werden