Outage Probability and Outage-Based Robust Beamforming for MIMO Interference Channels with Imperfect Channel State Information

In this paper, the outage probability and outage-based beam design for multiple-input multiple-output (MIMO) interference channels are considered. First, closed-form expressions for the outage probability in MIMO interference channels are derived under the assumption of Gaussian-distributed channel state information (CSI) error, and the asymptotic behavior of the outage probability as a function of several system parameters is examined by using the Chernoff bound. It is shown that the outage probability decreases exponentially with respect to the quality of CSI measured by the inverse of the mean square error of CSI. Second, based on the derived outage probability expressions, an iterative beam design algorithm for maximizing the sum outage rate is proposed. Numerical results show that the proposed beam design algorithm yields better sum outage rate performance than conventional algorithms such as interference alignment developed under the assumption of perfect CSI.Comment: 41 pages, 14 figures. accepted to IEEE Transactions on Wireless Communication

Non parametric reconstruction of distribution functions from observed galactic disks

A general inversion technique for the recovery of the underlying distribution function for observed galactic disks is presented and illustrated. Under the assumption that these disks are axi-symmetric and thin, the proposed method yields the unique distribution compatible with all the observables available. The derivation may be carried out from the measurement of the azimuthal velocity distribution arising from positioning the slit of a spectrograph along the major axis of the galaxy. More generally, it may account for the simultaneous measurements of velocity distributions corresponding to slits presenting arbitrary orientations with respect to the major axis. The approach is non-parametric, i.e. it does not rely on a particular algebraic model for the distribution function. Special care is taken to account for the fraction of counter-rotating stars which strongly affects the stability of the disk. An optimisation algorithm is devised -- generalising the work of Skilling & Bryan (1984) -- to carry this truly two-dimensional ill-conditioned inversion efficiently. The performances of the overall inversion technique with respect to the noise level and truncation in the data set is investigated with simulated data. Reliable results are obtained up to a mean signal to noise ratio of~5 and when measurements are available up to $4 R_{e}$. A discussion of the residual biases involved in non parametric inversions is presented. Prospects of application to observed galaxies and other inversion problems are discussed.Comment: 11 pages, 13 figures; accepted for publication by MNRA

The Kepler-10 planetary system revisited by HARPS-N: A hot rocky world and a solid Neptune-mass planet

Kepler-10b was the first rocky planet detected by the Kepler satellite and con- firmed with radial velocity follow-up observations from Keck-HIRES. The mass of the planet was measured with a precision of around 30%, which was insufficient to constrain models of its internal structure and composition in detail. In addition to Kepler-10b, a second planet transiting the same star with a period of 45 days was sta- tistically validated, but the radial velocities were only good enough to set an upper limit of 20 Mearth for the mass of Kepler-10c. To improve the precision on the mass for planet b, the HARPS-N Collaboration decided to observe Kepler-10 intensively with the HARPS-N spectrograph on the Telescopio Nazionale Galileo on La Palma. In to- tal, 148 high-quality radial-velocity measurements were obtained over two observing seasons. These new data allow us to improve the precision of the mass determina- tion for Kepler-10b to 15%. With a mass of 3.33 +/- 0.49 Mearth and an updated radius of 1.47 +0.03 -0.02 Rearth, Kepler-10b has a density of 5.8 +/- 0.8 g cm-3, very close to the value -0.02 predicted by models with the same internal structure and composition as the Earth. We were also able to determine a mass for the 45-day period planet Kepler-10c, with an even better precision of 11%. With a mass of 17.2 +/- 1.9 Mearth and radius of 2.35 +0.09 -0.04 Rearth, -0.04 Kepler-10c has a density of 7.1 +/- 1.0 g cm-3. Kepler-10c appears to be the first strong evidence of a class of more massive solid planets with longer orbital periods.Comment: 44 pages, 8 figures, accepted for publication in Ap

Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands.

BACKGROUND: The affinities of DNA binding proteins for target sites can be used to model the regulation of gene expression. These proteins can bind to DNA cooperatively, strongly impacting their affinity and specificity. However, current methods for measuring cooperativity do not provide the means to accurately predict binding behavior over a wide range of concentrations. METHODS: We use standard computational and mathematical methods, and develop novel methods as described in Results. RESULTS: We explore some complexities of cooperative binding, and develop an improved method for relating in vitro measurements to in vivo function, based on ternary complex formation. We derive expressions for the equilibria among the various complexes, and explore the limitations of binding experiments that model the system using a single parameter. We describe how to use single-ligand binding and ternary complex formation in tandem to determine parameters that have thermodynamic relevance. We develop an improved method for finding both single-ligand dissociation constants and concentrations simultaneously. We show how the cooperativity factor can be found when only one of the single-ligand dissociation constants can be measured. CONCLUSIONS: The methods that we develop constitute an optimized approach to accurately model cooperative binding. GENERAL SIGNIFICANCE: The expressions and methods we develop for modeling and analyzing DNA binding and cooperativity are applicable to most cases where multiple ligands bind to distinct sites on a common substrate. The parameters determined using these methods can be fed into models of higher-order cooperativity to increase their predictive power

Experimental Design for Sensitivity Analysis, Optimization and Validation of Simulation Models

This chapter gives a survey on the use of statistical designs for what-if analysis in simula- tion, including sensitivity analysis, optimization, and validation/verification. Sensitivity analysis is divided into two phases. The first phase is a pilot stage, which consists of screening or searching for the important factors among (say) hundreds of potentially important factors. A novel screening technique is presented, namely sequential bifurcation. The second phase uses regression analysis to approximate the input/output transformation that is implied by the simulation model; the resulting regression model is also known as a metamodel or a response surface. Regression analysis gives better results when the simu- lation experiment is well designed, using either classical statistical designs (such as frac- tional factorials) or optimal designs (such as pioneered by Fedorov, Kiefer, and Wolfo- witz). To optimize the simulated system, the analysts may apply Response Surface Metho- dology (RSM); RSM combines regression analysis, statistical designs, and steepest-ascent hill-climbing. To validate a simulation model, again regression analysis and statistical designs may be applied. Several numerical examples and case-studies illustrate how statisti- cal techniques can reduce the ad hoc character of simulation; that is, these statistical techniques can make simulation studies give more general results, in less time. Appendix 1 summarizes confidence intervals for expected values, proportions, and quantiles, in termi- nating and steady-state simulations. Appendix 2 gives details on four variance reduction techniques, namely common pseudorandom numbers, antithetic numbers, control variates or regression sampling, and importance sampling. Appendix 3 describes jackknifing, which may give robust confidence intervals.least squares;distribution-free;non-parametric;stopping rule;run-length;Von Neumann;median;seed;likelihood ratio

On the critical nature of plastic flow: one and two dimensional models

Steady state plastic flows have been compared to developed turbulence because the two phenomena share the inherent complexity of particle trajectories, the scale free spatial patterns and the power law statistics of fluctuations. The origin of the apparently chaotic and at the same time highly correlated microscopic response in plasticity remains hidden behind conventional engineering models which are based on smooth fitting functions. To regain access to fluctuations, we study in this paper a minimal mesoscopic model whose goal is to elucidate the origin of scale free behavior in plasticity. We limit our description to fcc type crystals and leave out both temperature and rate effects. We provide simple illustrations of the fact that complexity in rate independent athermal plastic flows is due to marginal stability of the underlying elastic system. Our conclusions are based on a reduction of an over-damped visco-elasticity problem for a system with a rugged elastic energy landscape to an integer valued automaton. We start with an overdamped one dimensional model and show that it reproduces the main macroscopic phenomenology of rate independent plastic behavior but falls short of generating self similar structure of fluctuations. We then provide evidence that a two dimensional model is already adequate for describing power law statistics of avalanches and fractal character of dislocation patterning. In addition to capturing experimentally measured critical exponents, the proposed minimal model shows finite size scaling collapse and generates realistic shape functions in the scaling laws.Comment: 72 pages, 40 Figures, International Journal of Engineering Science for the special issue in honor of Victor Berdichevsky, 201

Lensing reconstruction from line intensity maps: the impact of gravitational nonlinearity

We investigate the detection prospects for gravitational lensing of three-dimensional maps from upcoming line intensity surveys, focusing in particular on the impact of gravitational nonlinearities on standard quadratic lensing estimators. Using perturbation theory, we show that these nonlinearities can provide a significant contaminant to lensing reconstruction, even for observations at reionization-era redshifts. However, we show how this contamination can be mitigated with the use of a "bias-hardened" estimator. Along the way, we present an estimator for reconstructing long-wavelength density modes, in the spirit of the "tidal reconstruction" technique that has been proposed elsewhere, and discuss the dominant biases on this estimator. After applying bias-hardening, we find that a detection of the lensing potential power spectrum will still be challenging for the first phase of SKA-Low, CHIME, and HIRAX, with gravitational nonlinearities decreasing the signal to noise by a factor of a few compared to forecasts that ignore these effects. On the other hand, cross-correlations between lensing and galaxy clustering or cosmic shear from a large photometric survey look promising, provided that systematics can be sufficiently controlled. We reach similar conclusions for a single-dish survey inspired by CII measurements planned for CCAT-prime, suggesting that lensing is an interesting science target not just for 21cm surveys, but also for intensity maps of other lines.Comment: 40+18 pages, 13 figures, 5 tables. v2: JCAP published version, with typos fixed and clarifications adde

Reversed and increased functional connectivity in non-REM sleep suggests an altered rather than reduced state of consciousness relative to wake

Sleep resting state network (RSN) functional connectivity (FC) is poorly understood, particularly for rapid eye movement (REM), and in non-sleep deprived subjects. REM and non-REM (NREM) sleep involve competing drives; towards hypersynchronous cortical oscillations in NREM; and towards wake-like desynchronized oscillations in REM. This study employed simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) to explore whether sleep RSN FC reflects these opposing drives. As hypothesized, this was confirmed for the majority of functional connections modulated by sleep. Further, changes were directional: e.g., positive wake correlations trended towards negative correlations in NREM and back towards positive correlations in REM. Moreover, the majority did not merely reduce magnitude, but actually either reversed and strengthened in the opposite direction, or increased in magnitude during NREM. This finding supports the notion that NREM is best expressed as having altered, rather than reduced FC. Further, as many of these functional connections comprised “higher-order” RSNs (which have been previously linked to cognition and consciousness), such as the default mode network, this finding is suggestive of possibly concomitant alterations to cognition and consciousness

Enhancing 3D Autonomous Navigation Through Obstacle Fields: Homogeneous Localisation and Mapping, with Obstacle-Aware Trajectory Optimisation

Small flying robots have numerous potential applications, from quadrotors for search and rescue, infrastructure inspection and package delivery to free-flying satellites for assistance activities inside a space station. To enable these applications, a key challenge is autonomous navigation in 3D, near obstacles on a power, mass and computation constrained platform. This challenge requires a robot to perform localisation, mapping, dynamics-aware trajectory planning and control. The current state-of-the-art uses separate algorithms for each component. Here, the aim is for a more homogeneous approach in the search for improved efficiencies and capabilities. First, an algorithm is described to perform Simultaneous Localisation And Mapping (SLAM) with physical, 3D map representation that can also be used to represent obstacles for trajectory planning: Non-Uniform Rational B-Spline (NURBS) surfaces. Termed NURBSLAM, this algorithm is shown to combine the typically separate tasks of localisation and obstacle mapping. Second, a trajectory optimisation algorithm is presented that produces dynamically-optimal trajectories with direct consideration of obstacles, providing a middle ground between path planners and trajectory smoothers. Called the Admissible Subspace TRajectory Optimiser (ASTRO), the algorithm can produce trajectories that are easier to track than the state-of-the-art for flight near obstacles, as shown in flight tests with quadrotors. For quadrotors to track trajectories, a critical component is the differential flatness transformation that links position and attitude controllers. Existing singularities in this transformation are analysed, solutions are proposed and are then demonstrated in flight tests. Finally, a combined system of NURBSLAM and ASTRO are brought together and tested against the state-of-the-art in a novel simulation environment to prove the concept that a single 3D representation can be used for localisation, mapping, and planning