Computer Science Principles with Python

This textbook is intended to be used for a first course in computer science, such as the College Board’s Advanced Placement course known as AP Computer Science Principles (CSP). This book includes all the topics on the CSP exam, plus some additional topics. It takes a breadth-first approach, with an emphasis on the principles which form the foundation for hardware and software. No prior experience with programming should be required to use this book. This version of the book uses the Python programming language.https://rdw.rowan.edu/oer/1024/thumbnail.jp

Flexible manufacturing systems and the housing industry

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1997.Includes bibliographical references.by Frank Robert Altobelli.Ph.D

Membrane elastic heterogeneity studied at nanometrical scale on living cells

The aim of this thesis was to explore the cell mechanical properties using the Atomic Force Microscope (AFM). The cell membrane contains lipids microdomains, called rafts, enriched in cholesterol and sphingolipids. The rafts are believed to play an important role in signal processing by acting as a "signaling platform". Indeed, membrane proteins involved in signal transduction concentrates into these rafts and are coupled with signaling pathways inside the cell. The mechanical properties of these rafts were characterized by targeting one of its component, the glycosylphosphatidylinositol-anchored protein (GPI-AP). During this work, we found these domains to be stiffer than the surrounding membrane. Several control experiments were performed to consolidate this finding. The extraction of cholesterol, one of the major component of raft, was shown to dramatically reduce the stiffness of the raft to reach the surrounding membrane value. The stiffness specificity of rafts may be related to the lower diffusion rate of proteins and can be, therefore, an important property for its role as a signaling platform. During this thesis, we also introduced a new AFM imaging mode, which we called "stiffness tomography". With this imaging mode, we were able to distinguish stiff materials inclusion located into the sample. Different control experiments were done to validate this imaging mode. A virtual experiment was performed with the help of the finite element modeling. This permitted us to validate our methodology, but also pointed us its limitations. The stiffness tomography was also used on living cells and showed significant differences between native and cytoskeleton depolimerized cells. Since no postprocessing tool was available at the beginning of this work, the software development was a very significant part of the project. Its development resulted in a toolbox (a collection of function), that is available for future software development. A non negligible part of the development consisted in the toolbox documentation that is reported in the appendix C. This software permitted to process force volume AFM les and to characterize the elastic properties of the cell membrane with a high precision and reliability

Proceedings of the 9th MIT/ONR workshop on C3 Systems, held at Naval Postgraduate School and Hilton Inn Resort Hotel, Monterey, California June 2 through June 5, 1986

GRSN 627729"December 1986."Includes bibliographical references and index.Sponsored by Massachusetts Institute of Technology, Laboratory for Information and Decision Systems, Cambridge, Mass., with support from the Office of Naval Research. ONR/N00014-77-C-0532(NR041-519) Sponsored in cooperation with IEEE Control Systems Society, Technical Committee on C.edited by Michael Athans, Alexander H. Levis

Investigations of physical therapy interventions to enhance movement recovery in people after stroke: Development and design of a novel intervention embedding Functional Strength Training within a motor learning context

Stroke is the largest cause of adult disability in the UK and stroke survivors commonly present with a partial or complete loss of movement. Physical therapy interventions as part of movement rehabilitation after stroke aim to facilitate a return to participation in activities of daily living. It has been proposed that the processes that underpin both movement recovery following stroke and motor learning are the same. By embedding physical therapies within a motor learning context it is possible that the effects of the therapy could be enhanced. Yet the application of motor learning principles within the field of movement rehabilitation after stroke is fragmented and supported by evidence of their application in studies with healthy volunteers. This thesis aims to carry out a systematic review of the evidence for the effectiveness of the application of motor learning principles in movement rehabilitation after stroke and to combine this with findings from a feasibility study of Functional Strength Training. These findings will be used to design a novel intervention embedding FST within a motor learning context. Organisation and synthesis of the systematic review was guided by the development of a motor learning framework. Interpretation of the findings from the review showed some evidence in favour of the application of motor learning principles. A phase II randomised controlled trial of FST to the upper limb and lower limb in people within six months and five years after stroke showed evidence of feasibility for both interventions but indicated efficacy of the upper limb intervention only (p=0.046). These findings were combined to inform the design and delivery of a novel intervention, testing for proof of concept for this intervention is now required. This thesis suggests an alternative approach to the development of physical therapy interventions after stroke, however consensus for this needs to be achieved