Design of a CMOS-based microwave active channelized bandpass filter

A two-branch microwave active bandpass filter is designed through the channelized filtering technique as well as the transversal concept. Both the main and the auxiliary branches, connected without power dividers/combiners, rely on C-coupled active third order Chebyshev bandpass filters. A lumped element signal delay circuit is also introduced in the main channel. Active inductors based on the gyrator-C topology, are involved in the Chebyshev filters’ structure. CMOS-based Operational Transconductor Amplifier (OTA) circuits are the building blocks of these inductors. The proposed active transversal channelized filter produces an elliptic narrow band response, centered at 1.13 GHz. Simulation results, obtained by means of the PSPICE code according to the 0.18 μm TSMC MOS technology, indicate excellent performances illustrating good impedance matching, low insertion losses and high selectivity. Finally, the noise analysis shows that the filter has a low noise figure in the bandwidth

Magnetless circulators based on linear time-varying circuits

In a crowded electromagnetic spectrum with an ever‐increasing demand for higher data rates to enable multimedia‐rich applications and services, an efficient use of the available wireless resources becomes crucial. For this reason, full‐duplex communication, which doubles the transmission rate over a certain bandwidth compared to currently deployed half-duplex radios by operating the uplink and the downlink simultaneously on the same frequency, has been brought back into the spotlight after decades of being presumed impractical. This long‐held assumption has been particularly due to the lack of high performance low-cost and small-size circulators that could mitigate the strong self-interference at the RF frontend interface of full-duplex transceivers while, at the same time, permitting low-loss bi-directional communication using a single antenna. Traditionally, such non-reciprocal components were almost exclusively based on magnetic biasing of rare-earth ferrite materials, which results in bulky and expensive devices that are not suitable for the vast majority of commercial systems. Despite significant research efforts over the past few decades, none of the previous works managed to eliminate the magnet while satisfying all the challenging requirements dictated by the standards of real systems. In this dissertation, we introduce several newly invented magnetless circulators based on linear time-varying circuits that can overcome for the first time the limitations of all previous approaches. We analyze the presented circuits rigorously and validate them through simulations and measurements, showing unprecedented performance in all relevant metrics, thus holding the promise to enable full-duplex radios in the near futur

High performance continuous-time filters for information transfer systems

Vast attention has been paid to active continuous-time filters over the years. Thus as the cheap, readily available integrated circuit OpAmps replaced their discrete circuit versions, it became feasible to consider active-RC filter circuits using large numbers of OpAmps. Similarly the development of integrated operational transconductance amplifier (OTA) led to new filter configurations. This gave rise to OTA-C filters, using only active devices and capacitors, making it more suitable for integration. The demands on filter circuits have become ever more stringent as the world of electronics and communications has advanced. In addition, the continuing increase in the operating frequencies of modern circuits and systems increases the need for active filters that can perform at these higher frequencies; an area where the LC active filter emerges. What mainly limits the performance of an analog circuit are the non-idealities of the used building blocks and the circuit architecture. This research concentrates on the design issues of high frequency continuous-time integrated filters. Several novel circuit building blocks are introduced. A novel pseudo-differential fully balanced fully symmetric CMOS OTA architecture with inherent common-mode detection is proposed. Through judicious arrangement, the common-mode feedback circuit can be economically implemented. On the level of system architectures, a novel filter low-voltage 4th order RF bandpass filter structure based on emulation of two magnetically coupled resonators is presented. A unique feature of the proposed architecture is using electric coupling to emulate the effect of the coupled-inductors, thus providing bandwidth tuning with small passband ripple. As part of a direct conversion dual-mode 802.11b/Bluetooth receiver, a BiCMOS 5th order low-pass channel selection filter is designed. The filter operated from a single 2.5V supply and achieves a 76dB of out-of-band SFDR. A digital automatic tuning system is also implemented to account for process and temperature variations. As part of a Bluetooth transmitter, a low-power quadrature direct digital frequency synthesizer (DDFS) is presented. Piecewise linear approximation is used to avoid using a ROM look-up table to store the sine values in a conventional DDFS. Significant saving in power consumption, due to the elimination of the ROM, renders the design more suitable for portable wireless communication applications

Synthesis of Planar Microwave Circuits based on Metamaterial Concepts through Aggressive Space Mapping

RF and microwave applications represent one of the fastest-growing segments of the high performance electronics market, where ongoing innovation is critical. Manufacturers compete intensively to meet market needs with reduced cost, size, weight and many other performance criteria demands. Under this scenario, transmission lines based on metamaterial concepts can be considered a very interesting alternative to the conventional transmission lines. They are more compact (compatible with planar manufacturing processes) and present higher degrees of design flexibility. Furthermore, metamaterial transmission lines can also provide many other unique properties not achievable with ordinary transmission lines, such as dispersion or impedance engineering. Nevertheless, the impact in the industry is still not relevant, mostly due to the complexity of the related synthesis and design procedures. These procedures are mainly based on the engineer’s experience, with the help of costly full-wave electromagnetic (EM) simulators and parameter extraction methods. The aim of this thesis is to contribute to simplify and speed up the synthesis and design procedures of artificial transmission lines. In particular, the lines obtained by periodically loading a conventional transmission line with electrically small resonators, such as split ring resonators (SSRs) or its complementary particle (CSRR). The design procedure is automated by using Space Mapping techniques. In contrast to other alternative methods, real synthesis is found from the circuit schematic (that provides a given target response) and without need of human intervention. Some efforts to make the method practical and useful have been carried out. Given a certain target response, it is determined whether it can be physically implemented with a chosen technology, and hence proceeding next to find the synthesis, or not. For this purpose, a two-step Aggressive Space Mapping approach is successfully proposed. In contrast to other methods, the real synthesis is found from certain target circuit values (corresponding to the equivalent circuit model that characterizes the structure to be synthesized). Different efforts have been carried out in order to implement a useful and practical method. Some of them were focused to determine if, given certain circuit parameters (which determine the target response) and certain given technology specifications (permittivity and height of the substrate, technology limits), that response is physically realizable (convergence region). This technique was successfully formulated and it is known as “Two-Step Aggressive Space Mapping Approach”. In this work, the latest improvements made till date, from the synthesis of basic unit cells until different applications and kinds of metamaterial-based circuits, are presented. The results are promising and prove the validity of the method, as well as its potential application to other basic cells and more complex designs. The general knowledge gained from these cases of study can be considered a good base for a coming implementation in commercial software tools, which can help to improve its competitiveness in markets, and also contribute to a more general use of this technology.Rodríguez Pérez, AM. (2014). Synthesis of Planar Microwave Circuits based on Metamaterial Concepts through Aggressive Space Mapping [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/48465TESI

UWB Technology

Ultra Wide Band (UWB) technology has attracted increasing interest and there is a growing demand for UWB for several applications and scenarios. The unlicensed use of the UWB spectrum has been regulated by the Federal Communications Commission (FCC) since the early 2000s. The main concern in designing UWB circuits is to consider the assigned bandwidth and the low power permitted for transmission. This makes UWB circuit design a challenging mission in today's community. Various circuit designs and system implementations are published in this book to give the reader a glimpse of the state-of-the-art examples in this field. The book starts at the circuit level design of major UWB elements such as filters, antennas, and amplifiers; and ends with the complete system implementation using such modules

Co-design of Reconfigurable and Multifunction Passive RF/Microwave Components

In order to meet the market demands, multi-band communication systems that are able to accommodate different wireless technologies to be compatible with different wireless standards should be investigated and realized. Multifunction and multi-band RF front-end components are promising solutions for reducing the size and enhancing the performance of multi-band communication systems. This dissertation focuses on the design and implementation of different multifunction and tunable microwave components for use in multi-standard, flexible transceiver. For frequency-domain duplexing (FDD) communication systems, in which the uplink and downlink channels are carried on different RF frequencies, a diplexer is an essential component to separate the transmitting and receiving signals from the antenna. Electrically tunable diplexers simplify the architecture of reconfigurable RF-front end. Moreover, in modern communication systems, the crowding of the spectrum and the scaling of electronics can result in higher common-mode interference and even-order non-linearity issues. In this dissertation, three tunable compact SIW-based dual-mode diplexers, with various SE (single-ended) and BAL (balanced) capabilities, are introduced for the first time. The dual-mode operation results in a dependent tuning between the two ports. The presented designs are for SE-SE, SE-BAL, and BAL-BAL. However, based on the presented design concepts, any combination of the diplexer ports can be achieved in terms of supporting the balanced and single-ended system interface. The fabricated diplexers show low insertion loss, high isolation, good tuning range and high common mode rejection. Tunable bandstop filter (BSF) is one of the essential components in the design of RF front-ends that require wide-band operations. A wide-open front-end leaves the receiver vulnerable to jamming by high-power signals. As a result, this type of front-ends requires dynamic isolation of any interfering signal. Realization of such filters in a balanced configuration, as a second function, is an important step in the realization of full-balanced RF front-ends. Balanced (differential) circuits have many important advantages over unbalanced (single-ended) circuits such as immunity to system noise, reduction of transient noise generation and inherent suppression of even-order nonlinearities. All reported balanced filters are bandpass filters that target wide pass-bands and high common-mode rejection. These filters are necessary for wide-band RF front-ends but, as mentioned above, leave the system open to interferers and jammers. In this dissertation, a new differential coupling structure for evanescent-mode cavity resonators is developed, enabling the design of fully-balanced tunable BSF. The proposed filter is tunable from 1.57-3.18 GHz with 102% tuning range. In addition, over the full range, the measured 10-dB fractional bandwidth ranges from 1-2.4%, and the attenuation level is better than 47 dB. Lastly, Substrate Integrated Waveguide (SIW) evanescent-mode cavity resonators (EVA) are employed in the design of RF couplers, quadrature hybrid and rat-race couplers. These couplers are used in the design of numerous RF front-end components such as power amplifiers, balanced mixers, and antenna array feeding networks. Utilizing such resonators (EVA) in the design allows the couplers to have wide spurious-free range, low power consumption, high power handling capability and both tunability and filtering capabilities. The proposed quadrature hybrid coupler can be tuned starting from 1.32–2.22 GHz with a measured insertion loss range from 1.29 to 0.7 dB. The measured reflection and isolation are better than 12 dB and 17 dB, respectively. Moreover, the coupler has a measured spurious free range of 5.1–3fo (lowest–highest frequency). Regarding rat-race coupler, two designs are introduced. The first design is based on a full-mode cavity while the second one is more compact and based on a half-mode cavity. Both designs show more than 70% tuning range, and the isolation is better than 30 dB

A Novel Doxorubicin Prodrug with Controllable Photolysis Activation for Cancer Chemotherapy

Doxorubicin (DOX) is a very effective anticancer agent. However, in its pure form, its application is limited by significant cardiotoxic side effects. The purpose of this study was to develop a controllably activatable chemotherapy prodrug of DOX created by blocking its free amine group with a biotinylated photocleavable blocking group (PCB). An n-hydroxy succunamide protecting group on the PCB allowed selective binding at the DOX active amine group. The PCB included an ortho-nitrophenyl group for photo cleavability and a water-soluble glycol spacer arm ending in a biotin group for enhanced membrane interaction. This novel DOX-PCB prodrug had a 200-fold decrease in cytotoxicity compared to free DOX and could release active DOX upon exposure to UV light at 350 nm. Unlike DOX, DOX-PCB stayed in the cell cytoplasm, did not enter the nucleus, and did not stain the exposed DNA during mitosis. Human liver microsome incubation with DOX-PCB indicated stability against liver metabolic breakdown. The development of the DOX-PCB prodrug demonstrates the possibility of using light as a method of prodrug activation in deep internal tissues without relying on inherent physical or biochemical differences between the tumor and healthy tissue for use as the trigger

The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells.

The p53 tumor suppressor protein plays a crucial role in influencing cell fate decisions in response to cellular stress. As p53 elicits cell cycle arrest, senescence or apoptosis, the integrity of the p53 pathway is considered a key determinant of anti-tumor responses. p53 can also promote autophagy, however the role of p53-dependent autophagy in chemosensitivity is poorly understood. VMY-1-103 (VMY), a dansylated analog of purvalanol B, displays rapid and potent anti-tumor activities, however the pathways by which VMY works are not fully defined. Using established prostate cancer cell lines and novel conditionally reprogrammed cells (CRCs) derived from prostate cancer patients; we have defined the mechanisms of VMY-induced prostate cancer cell death. Herein, we show that the cytotoxic effects of VMY required a p53-dependent induction of autophagy, and that inhibition of autophagy abrogated VMY-induced cell death. Cancer cell lines harboring p53 missense mutations evaded VMY toxicity and treatment with a small molecule compound that restores p53 activity re-established VMY-induced cell death. The elucidation of the molecular mechanisms governing VMY-dependent cell death in cell lines, and importantly in CRCs, provides the rationale for clinical studies of VMY, alone or in combination with p53 reactivating compounds, in human prostate cancer