312 research outputs found
Data-driven modelling of biological multi-scale processes
Biological processes involve a variety of spatial and temporal scales. A
holistic understanding of many biological processes therefore requires
multi-scale models which capture the relevant properties on all these scales.
In this manuscript we review mathematical modelling approaches used to describe
the individual spatial scales and how they are integrated into holistic models.
We discuss the relation between spatial and temporal scales and the implication
of that on multi-scale modelling. Based upon this overview over
state-of-the-art modelling approaches, we formulate key challenges in
mathematical and computational modelling of biological multi-scale and
multi-physics processes. In particular, we considered the availability of
analysis tools for multi-scale models and model-based multi-scale data
integration. We provide a compact review of methods for model-based data
integration and model-based hypothesis testing. Furthermore, novel approaches
and recent trends are discussed, including computation time reduction using
reduced order and surrogate models, which contribute to the solution of
inference problems. We conclude the manuscript by providing a few ideas for the
development of tailored multi-scale inference methods.Comment: This manuscript will appear in the Journal of Coupled Systems and
Multiscale Dynamics (American Scientific Publishers
SOLID-SHELL FINITE ELEMENT MODELS FOR EXPLICIT SIMULATIONS OF CRACK PROPAGATION IN THIN STRUCTURES
Crack propagation in thin shell structures due to cutting is conveniently simulated
using explicit finite element approaches, in view of the high nonlinearity of the problem. Solidshell
elements are usually preferred for the discretization in the presence of complex material
behavior and degradation phenomena such as delamination, since they allow for a correct
representation of the thickness geometry. However, in solid-shell elements the small thickness
leads to a very high maximum eigenfrequency, which imply very small stable time-steps. A new
selective mass scaling technique is proposed to increase the time-step size without affecting
accuracy. New ”directional” cohesive interface elements are used in conjunction with selective
mass scaling to account for the interaction with a sharp blade in cutting processes of thin ductile
shells
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