Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Speech segmentation and clustering methods for a new speech recognition architecture

Perinteiset automaattiset puheentunnistusmenetelmät eivät pärjää suorituskyvyssä ihmisen puheenhavaintokyvylle. Voidaksemme kuroa tämän eron umpeen, on kehitettävä täysin uudentyyppisiä arkkitehtuureja puheentunnistusta varten. Puhetta ja kieltä itsestään ihmisen lailla oppiva järjestelmä on yksi tällainen vaihtoehto. Tämä diplomityö esittelee erään lähtökohdan oppivalle järjestelmälle, koostuen uudenlaisesta sokeasta puheen segmentointialgoritmista, segmenttien piirteistyksestä, sekä menetelmistä vähittäiselle puhedatan luokittelulle klusteroinnin avulla. Kaikki metodit arvioitiin kattavilla kokeilla, ja itse arviontimenetelmien luonteeseen kiinnitettiin huomiota. Segmentoinnissa saavutettiin alan kirjallisuuteen nähden hyvät tulokset. Järjestelmän mahdollisia jatkokehityssuuntauksia on hahmoteltu muunmuassa mahdollisten muistiarkkitehtuurien ja älykkään top-down palautteen osalta.To reduce the gap between performance of traditional speech recognition systems and human speech recognition skills, a new architecture is required. A system that is capable of incremental learning offers one such solution to this problem. This thesis introduces a bottom-up approach for such a speech processing system, consisting of a novel blind speech segmentation algorithm, a segmental feature extraction methodology, and data classification by incremental clustering. All methods were evaluated by extensive experiments with a broad range of test material and the evaluation methodology was itself also scrutinized. The segmentation algorithm achieved above standard quality results compared to what is found in current literature regarding blind segmentation. Possibilities for follow-up research of memory structures and intelligent top-down feedback in speech processing are also outlined

Speech Recognition

Chapters in the first part of the book cover all the essential speech processing techniques for building robust, automatic speech recognition systems: the representation for speech signals and the methods for speech-features extraction, acoustic and language modeling, efficient algorithms for searching the hypothesis space, and multimodal approaches to speech recognition. The last part of the book is devoted to other speech processing applications that can use the information from automatic speech recognition for speaker identification and tracking, for prosody modeling in emotion-detection systems and in other speech processing applications that are able to operate in real-world environments, like mobile communication services and smart homes

A Study of Accomodation of Prosodic and Temporal Features in Spoken Dialogues in View of Speech Technology Applications

Inter-speaker accommodation is a well-known property of human speech and human interaction in general. Broadly it refers to the behavioural patterns of two (or more) interactants and the effect of the (verbal and non-verbal) behaviour of each to that of the other(s). Implementation of thisbehavior in spoken dialogue systems is desirable as an improvement on the naturalness of humanmachine interaction. However, traditional qualitative descriptions of accommodation phenomena do not provide sufficient information for such an implementation. Therefore, a quantitativedescription of inter-speaker accommodation is required. This thesis proposes a methodology of monitoring accommodation during a human or humancomputer dialogue, which utilizes a moving average filter over sequential frames for each speaker. These frames are time-aligned across the speakers, hence the name Time Aligned Moving Average (TAMA). Analysis of spontaneous human dialogue recordings by means of the TAMA methodology reveals ubiquitous accommodation of prosodic features (pitch, intensity and speech rate) across interlocutors, and allows for statistical (time series) modeling of the behaviour, in a way which is meaningful for implementation in spoken dialogue system (SDS) environments.In addition, a novel dialogue representation is proposed that provides an additional point of view to that of TAMA in monitoring accommodation of temporal features (inter-speaker pause length and overlap frequency). This representation is a percentage turn distribution of individual speakercontributions in a dialogue frame which circumvents strict attribution of speaker-turns, by considering both interlocutors as synchronously active. Both TAMA and turn distribution metrics indicate that correlation of average pause length and overlap frequency between speakers can be attributed to accommodation (a debated issue), and point to possible improvements in SDS “turntaking” behaviour. Although the findings of the prosodic and temporal analyses can directly inform SDS implementations, further work is required in order to describe inter-speaker accommodation sufficiently, as well as to develop an adequate testing platform for evaluating the magnitude ofperceived improvement in human-machine interaction. Therefore, this thesis constitutes a first step towards a convincingly useful implementation of accommodation in spoken dialogue systems

Automatic Emotion Recognition: Quantifying Dynamics and Structure in Human Behavior.

Emotion is a central part of human interaction, one that has a huge influence on its overall tone and outcome. Today's human-centered interactive technology can greatly benefit from automatic emotion recognition, as the extracted affective information can be used to measure, transmit, and respond to user needs. However, developing such systems is challenging due to the complexity of emotional expressions and their dynamics in terms of the inherent multimodality between audio and visual expressions, as well as the mixed factors of modulation that arise when a person speaks. To overcome these challenges, this thesis presents data-driven approaches that can quantify the underlying dynamics in audio-visual affective behavior. The first set of studies lay the foundation and central motivation of this thesis. We discover that it is crucial to model complex non-linear interactions between audio and visual emotion expressions, and that dynamic emotion patterns can be used in emotion recognition. Next, the understanding of the complex characteristics of emotion from the first set of studies leads us to examine multiple sources of modulation in audio-visual affective behavior. Specifically, we focus on how speech modulates facial displays of emotion. We develop a framework that uses speech signals which alter the temporal dynamics of individual facial regions to temporally segment and classify facial displays of emotion. Finally, we present methods to discover regions of emotionally salient events in a given audio-visual data. We demonstrate that different modalities, such as the upper face, lower face, and speech, express emotion with different timings and time scales, varying for each emotion type. We further extend this idea into another aspect of human behavior: human action events in videos. We show how transition patterns between events can be used for automatically segmenting and classifying action events. Our experimental results on audio-visual datasets show that the proposed systems not only improve performance, but also provide descriptions of how affective behaviors change over time. We conclude this dissertation with the future directions that will innovate three main research topics: machine adaptation for personalized technology, human-human interaction assistant systems, and human-centered multimedia content analysis.PhDElectrical Engineering: SystemsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/133459/1/yelinkim_1.pd

A robust framework for medical image segmentation through adaptable class-specific representation

Medical image segmentation is an increasingly important component in virtual pathology, diagnostic imaging and computer-assisted surgery. Better hardware for image acquisition and a variety of advanced visualisation methods have paved the way for the development of computer based tools for medical image analysis and interpretation. The routine use of medical imaging scans of multiple modalities has been growing over the last decades and data sets such as the Visible Human Project have introduced a new modality in the form of colour cryo section data. These developments have given rise to an increasing need for better automatic and semiautomatic segmentation methods. The work presented in this thesis concerns the development of a new framework for robust semi-automatic segmentation of medical imaging data of multiple modalities. Following the specification of a set of conceptual and technical requirements, the framework known as ACSR (Adaptable Class-Specific Representation) is developed in the first case for 2D colour cryo section segmentation. This is achieved through the development of a novel algorithm for adaptable class-specific sampling of point neighbourhoods, known as the PGA (Path Growing Algorithm), combined with Learning Vector Quantization. The framework is extended to accommodate 3D volume segmentation of cryo section data and subsequently segmentation of single and multi-channel greyscale MRl data. For the latter the issues of inhomogeneity and noise are specifically addressed. Evaluation is based on comparison with previously published results on standard simulated and real data sets, using visual presentation, ground truth comparison and human observer experiments. ACSR provides the user with a simple and intuitive visual initialisation process followed by a fully automatic segmentation. Results on both cryo section and MRI data compare favourably to existing methods, demonstrating robustness both to common artefacts and multiple user initialisations. Further developments into specific clinical applications are discussed in the future work section