ISIS in America: A Sociohistorical Analysis

During the summer of 2014, the terrorist organization Islamic State (commonly referred to as Islamic State in Iraq and Syria, or ISIS) garnered international attention after its unprecedented territorial acquisitions and violence in the Middle East. Today, ISIS vies with al-Qaeda for leadership of the global Islamic Extremist movement and has extended its violence all over the world, including the United States. U.S. based supporters generally choose to engage with the ideology in one of three categories: as a foreign fighter, domestic plotter, or domestic non-plotter. Despite this threat, there is very little quantitative research concerning U.S. ISIS supporters and the incidents they plan. Utilizing data from the American Terrorism Study (ATS), the current study compares ISIS perpetrators across the three support type categories, as well as ISIS and al-Qaeda and Associated Movements (AQAM) affiliated persons and incidents in the United States. I conducted Chi Square and Conjunctive Analysis of Case Configurations to determine significant differences. The analysis indicated significant difference across ISIS support types with regard to gender and age of the individuals, and suggested common patterns in the types of individuals who choose to leave the U.S. or stay and engage in violence. Additional analysis indicated significant differences in the residency status and race between ISIS and AQAM perpetrators. Finally, results showed that, although ISIS and AQAM incidents have different configurations concerning targets, weapons, and group size, their success rates are relatively the same. In conclusion, there are important differences between ISIS and AQAM affiliated persons and incidents that may merit considering them as separate entities rather than together under the umbrella of Islamic Extremist

NASTRAN maintenance and enhancement experiences

The current capability is described which includes isoparametric elements, optimization of grid point sequencing, and eigenvalue routine. Overlay and coding errors were corrected for cyclic symmetry, transient response, and differential stiffness rigid formats. Error corrections and program enhancements are discussed along with developments scheduled for the current year and a brief description of analyses being performed using the program

Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay.

Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromatin mapping. Applying Tn5 tagmentation to hundreds of cells results in sparse chromatin maps. We present a transposome hypersensitive sites sequencing assay for highly sensitive characterization of chromatin accessibility. Linear amplification of accessible DNA ends with in vitro transcription, coupled with an engineered Tn5 super-mutant, demonstrates improved sensitivity on limited input materials, and accessibility of small regions near distal enhancers, compared with ATAC-seq

A user-friendly, menu-driven, language-free laser characteristics curves graphing program for desk-top IBM PC compatible computers

A facility was established that uses collected data and feeds it into mathematical models that generate improved data arrays by correcting for various losses, base line drift, and conversion to unity scaling. These developed data arrays have headers and other identifying information affixed and are subsequently stored in a Laser Materials and Characteristics data base which is accessible to various users. The two part data base: absorption - emission spectra and tabulated data, is developed around twelve laser models. The tabulated section of the data base is divided into several parts: crystalline, optical, mechanical, and thermal properties; aborption and emission spectra information; chemical name and formulas; and miscellaneous. A menu-driven, language-free graphing program will reduce and/or remove the requirement that users become competent FORTRAN programmers and the concomitant requirement that they also spend several days to a few weeks becoming conversant with the GEOGRAF library and sequence of calls and the continual refreshers of both. The work included becoming thoroughly conversant with or at least very familiar with GEOGRAF by GEOCOMP Corp. The development of the graphing program involved trial runs of the various callable library routines on dummy data in order to become familiar with actual implementation and sequencing. This was followed by trial runs with actual data base files and some additional data from current research that was not in the data base but currently needed graphs. After successful runs, with dummy and real data, using actual FORTRAN instructions steps were undertaken to develop the menu-driven language-free implementation of a program which would require the user only know how to use microcomputers. The user would simply be responding to items displayed on the video screen. To assist the user in arriving at the optimum values needed for a specific graph, a paper, and pencil check list was made available to use on the trial runs

The impact of sequence database choice on metaproteomic results in gut microbiota studies

Background: Elucidating the role of gut microbiota in physiological and pathological processes has recently emerged as a key research aim in life sciences. In this respect, metaproteomics, the study of the whole protein complement of a microbial community, can provide a unique contribution by revealing which functions are actually being expressed by specific microbial taxa. However, its wide application to gut microbiota research has been hindered by challenges in data analysis, especially related to the choice of the proper sequence databases for protein identification. Results: Here, we present a systematic investigation of variables concerning database construction and annotation and evaluate their impact on human and mouse gut metaproteomic results. We found that both publicly available and experimental metagenomic databases lead to the identification of unique peptide assortments, suggesting parallel database searches as a mean to gain more complete information. In particular, the contribution of experimental metagenomic databases was revealed to be mandatory when dealing with mouse samples. Moreover, the use of a "merged" database, containing all metagenomic sequences from the population under study, was found to be generally preferable over the use of sample-matched databases. We also observed that taxonomic and functional results are strongly database-dependent, in particular when analyzing the mouse gut microbiota. As a striking example, the Firmicutes/Bacteroidetes ratio varied up to tenfold depending on the database used. Finally, assembling reads into longer contigs provided significant advantages in terms of functional annotation yields. Conclusions: This study contributes to identify host- and database-specific biases which need to be taken into account in a metaproteomic experiment, providing meaningful insights on how to design gut microbiota studies and to perform metaproteomic data analysis. In particular, the use of multiple databases and annotation tools has to be encouraged, even though this requires appropriate bioinformatic resources

CGtag: Complete genomics toolkit and annotation in a cloud-based Galaxy

Background: Complete Genomics provides an open-source suite of command-line tools for the analysis of their CG-formatted mapped sequencing files. Determination of; for example, the functional impact of detected variants, requires annotation with various databases that often require command-line and/or programming experience; thus, limiting their use to the average research scientist. We have therefore implemented this CG toolkit, together with a number of annotation, visualisation and file manipulation tools in Galaxy called CGtag (Complete Genomics Toolkit and Annotation in a Cloud-based Galaxy).Findings: In order to provide research scientists with web-based, simple and accurate analytical and visualisation applications for the selection of candidate mutations from Complete Genomics data, we have implemented the open-source Complete Genomics tool set, CGATools, in Galaxy. In addition we implemented some of the most popular command-line annotation and visualisation tools to allow research scientists to select candidate pathological mutations (SNV, and indels). Furthermore, we have developed a cloud-based public Galaxy instance to host the CGtag toolkit and other associated modules.Conclusions: CGtag provides a user-friendly interface to all research scientists wishing to select candidate variants from CG or other next-generation sequencing platforms' data. By using a cloud-based infrastructure, we can also assure sufficient and on-demand computation and storage resources to handle the analysis tasks. The tools are freely available for use from an NBIC/CTMM-TraIT (The Netherlands Bioinformatics Center/Center for Translational Molecular Medicine) cloud-based Galaxy instance, or can be installed to a local (production) Galaxy via the NBIC Galaxy tool shed

A computer software system for integration and analysis of grid-based remote sensing data with other natural resource data. Remote Sensing Project

A computer-based information system is described designed to assist in the integration of commonly available spatial data for regional planning and resource analysis. The Resource Analysis Program (RAP) provides a variety of analytical and mapping phases for single factor or multi-factor analyses. The unique analytical and graphic capabilities of RAP are demonstrated with a study conducted in Windsor Township, Eaton County, Michigan. Soil, land cover/use, topographic and geological maps were used as a data base to develope an eleven map portfolio. The major themes of the portfolio are land cover/use, non-point water pollution, waste disposal, and ground water recharge

Banning design automation software implementation

The research is reported for developing a system of computer programs to aid engineering in the design, fabrication, and testing of large scale integrated circuits, hybrid circuits, and printed circuit boards. The automatic layout programs, analysis programs, and interface programs are discussed

A new high-speed solar radio spectrograph for meter and decameter wavelengths

The design and characteristics of a high resolution, digital solar spectrograph are discussed. The spectrometer operates in the 10 to 80 MHz range. The primary considerations in the design of the spectrograph were: (1) optimun sensitivity, (2) wide dynamic range, (3) flexibility in time and frequency resolution, and (4) modern data handling techniques with a simple computer interface

Description of the All-Sky camera, its Method of Operation; An Instrument (Ascagraph) for Measuring the Film

The earlier orbits and ephemerides for the Soviet satellites were not sufficiently accurate to be very useful in making observations in Alaska. Extrapolations from our own observations gave better predictions. This merely pointed out the fact that rough observations of meridian transits at high latitudes will give better values of the inclination of the orbit than precision observations at low latitudes. Hence, it was decided to observe visually the meridian transits estimating the altitude by noting the position with respect to the stars or using crude alidade measurements. The times of the earlier observations were observed on a watch or clock and the clock correction obtained from WWV. Later the times were determined with the aid of stop watches, taking time intervals from WWV signals. This rather meager program of optical observations of the Soviet satellites was undertaken to give supplementary data for use of the radio observations, and particularly to assist in the prediction of position of the satellite so that the 61-foot radar of Stanford Research Institute could be set accurately enough to observe it (the beam width at the half-power points is about 3°). This report contains primarily the visual observations made at the Geophysical Institute by various members of the staff, and a series of observations by Olaf Halverson at Nome, Alaska. In addition there is a short discussion of the geometry of the trajectory, the illumination of a circumpolar satellite, and a note on the evaluation of Brouwer's moment factors.IGY Project Number 1.1 ; NSF Grant Number Y/1.1/44LIST OF FIGURES AND ILLUSTRATIONS -- I Introduction -- II Description of the All-Sky Camera -- III Installation and Operation -- IV Development of the Film , Inspection, and Preliminary Assessment -- V Preparation of Synoptic Maps -- VI Auroral Plotter (Ascagraph) for Reduction of All-Sky Camera PhotographsYe