Compensation for Nonuniform Resolution Using Penalized-Likelihood Reconstruction in Space-Variant Imaging Systems

Imaging systems that form estimates using a statistical approach generally yield images with nonuniform resolution properties. That is, the reconstructed images possess resolution properties marked by space-variant and/or anisotropic responses. We have previously developed a space-variant penalty for penalized-likelihood (PL) reconstruction that yields nearly uniform resolution properties . We demonstrated how to calculate this penalty efficiently and apply it to an idealized positron emission tomography (PET) system whose geometric response is space-invariant. In this paper, we demonstrate the efficient calculation and application of this penalty to space-variant systems. (The method is most appropriate when the system matrix has been precalculated.) We apply the penalty to a large field of view PET system where crystal penetration effects make the geometric response space-variant, and to a two-dimensional single photon emission computed tomography system whose detector responses are modeled by a depth-dependent Gaussian with linearly varying full-width at half-maximum. We perform a simulation study comparing reconstructions using our proposed PL approach with other reconstruction methods and demonstrate the relative resolution uniformity, and discuss tradeoffs among estimators that yield nearly uniform resolution. We observe similar noise performance for the PL and post-smoothed maximum-likelihood (ML) approaches with carefully matched resolution, so choosing one estimator over another should be made on other factors like computational complexity and convergence rates of the iterative reconstruction. Additionally, because the postsmoothed ML and the proposed PL approach can outperform one another in terms of resolution uniformity depending on the desired reconstruction resolution, we present and discuss a hybrid approach adopting both a penalty and post-smoothing.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85975/1/Fessler63.pd

Regularized reconstruction in quantitative SPECT using CT side information from hybrid imaging

A penalized-likelihood (PL) SPECT reconstruction method using a modified regularizer that accounts for anatomical boundary side information was implemented to achieve accurate estimates of both the total target activity and the activity distribution within targets. In both simulations and experimental I-131 phantom studies, reconstructions from (1) penalized likelihood employing CT-side information-based regularization (PL-CT), (2) penalized likelihood with edge preserving regularization (no CT) and (3) penalized likelihood with conventional spatially invariant quadratic regularization (no CT) were compared with (4) ordered subset expectation maximization (OSEM), which is the iterative algorithm conventionally used in clinics for quantitative SPECT. Evaluations included phantom studies with perfect and imperfect side information and studies with uniform and non-uniform activity distributions in the target. For targets with uniform activity, the PL-CT images and profiles were closest to the 'truth', avoided the edge offshoots evident with OSEM and minimized the blurring across boundaries evident with regularization without CT information. Apart from visual comparison, reconstruction accuracy was evaluated using the bias and standard deviation (STD) of the total target activity estimate and the root mean square error (RMSE) of the activity distribution within the target. PL-CT reconstruction reduced both bias and RMSE compared with regularization without side information. When compared with unregularized OSEM, PL-CT reduced RMSE and STD while bias was comparable. For targets with non-uniform activity, these improvements with PL-CT were observed only when the change in activity was matched by a change in the anatomical image and the corresponding inner boundary was also used to control the regularization. In summary, the present work demonstrates the potential of using CT side information to obtain improved estimates of the activity distribution in targets without sacrificing the accuracy of total target activity estimation. The method is best suited for data acquired on hybrid systems where SPECT-CT misregistration is minimized. To demonstrate clinical application, the PL reconstruction with CT-based regularization was applied to data from a patient who underwent SPECT/CT imaging for tumor dosimetry following I-131 radioimmunotherapy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85409/1/pmb10_9_007.pd

Regularization for Uniform Spatial Resolution Properties in Penalized-Likelihood Image Reconstruction

Traditional space-invariant regularization methods in tomographic image reconstruction using penalized-likelihood estimators produce images with nonuniform spatial resolution properties. The local point spread functions that quantify the smoothing properties of such estimators are space variant, asymmetric, and object-dependent even for space invariant imaging systems. The authors propose a new quadratic regularization scheme for tomographic imaging systems that yields increased spatial uniformity and is motivated by the least-squares fitting of a parameterized local impulse response to a desired global response. The authors have developed computationally efficient methods for PET systems with shift-invariant geometric responses. They demonstrate the increased spatial uniformity of this new method versus conventional quadratic regularization schemes in simulated PET thorax scans.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85867/1/Fessler79.pd

Fast Predictions of Variance Images for Fan-Beam Transmission Tomography With Quadratic Regularization

Accurate predictions of image variances can be useful for reconstruction algorithm analysis and for the design of regularization methods. Computing the predicted variance at every pixel using matrix-based approximations is impractical. Even most recently adopted methods that are based on local discrete Fourier approximations are impractical since they would require a forward and backprojection and two fast Fourier transform (FFT) calculations for every pixel, particularly for shift-variant systems like fan-beam tomography. This paper describes new "analytical" approaches to predicting the approximate variance maps of 2-D images that are reconstructed by penalized-likelihood estimation with quadratic regularization in fan-beam geometries. The simplest of the proposed analytical approaches requires computation equivalent to one backprojection and some summations, so it is computationally practical even for the data sizes in X-ray computed tomography (CT). Simulation results show that it gives accurate predictions of the variance maps. The parallel-beam geometry is a simple special case of the fan-beam analysis. The analysis is also applicable to 2-D positron emission tomography (PET).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86007/1/Fessler37.pd

Analytical Approach to Regularization Design for Isotropic Spatial Resolution

In emission tomography, conventional quadratic regularization methods lead to nonuniform and anisotropic spatial resolution in penalized-likelihood (or MAP) reconstructed images, even for idealized shift-invariant imaging systems. Previous methods for designing regularizers that improve resolution uniformity have used matrix manipulations and discrete Fourier transforms. This paper describes a simpler approach for designing data-dependent, shift-variant regularizers. We replace the usual discrete system models used in statistical image reconstruction with locally shift-invariant, continuous-space approximations, and design the regularizer using analytical Fourier transforms. We discretize the final analytical solution to compute the regularizer coefficients. This new approach requires even less computation than previous approaches that used FFTs, and provides additional insight into the problem of designing regularization methods to achieve uniform, isotropic spatial resolution.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85963/1/Fessler187.pd

Non-uniform resolution and partial volume recovery in tomographic image reconstruction methods

Acquired data in tomographic imaging systems are subject to physical or detector based image degrading effects. These effects need to be considered and modeled in order to optimize resolution recovery. However, accurate modeling of the physics of data and acquisition processes still lead to an ill-posed reconstruction problem, because real data is incomplete and noisy. Real images are always a compromise between resolution and noise; therefore, noise processes also need to be fully considered for optimum bias variance trade off. Image degrading effects and noise are generally modeled in the reconstruction methods, while, statistical iterative methods can better model these effects, with noise processes, as compared to the analytical methods. Regularization is used to condition the problem and explicit regularization methods are considered better to model various noise processes with an extended control over the reconstructed image quality. Emission physics through object distribution properties are modeled in form of a prior function. Smoothing and edge-preserving priors have been investigated in detail and it has been shown that smoothing priors over-smooth images in high count areas and result in spatially non-uniform and nonlinear resolution response. Uniform resolution response is desirable for image comparison and other image processing tasks, such as segmentation and registration. This work proposes methods, based on MRPs in MAP estimators, to obtain images with almost uniform and linear resolution characteristics, using nonlinearity of MRPs as a correction tool. Results indicate that MRPs perform better in terms of response linearity, spatial uniformity and parameter sensitivity, as compared to QPs and TV priors. Hybrid priors, comprised of MRPs and QPs, have been developed and analyzed for their activity recovery performance in two popular PVC methods and for an analysis of list-mode data reconstruction methods showing that MPRs perform better than QPs in different situations