A passivity-based stability criterion for a class of interconnected systems and applications to biochemical reaction networks

This paper presents a stability test for a class of interconnected nonlinear systems motivated by biochemical reaction networks. One of the main results determines global asymptotic stability of the network from the diagonal stability of a "dissipativity matrix" which incorporates information about the passivity properties of the subsystems, the interconnection structure of the network, and the signs of the interconnection terms. This stability test encompasses the "secant criterion" for cyclic networks presented in our previous paper, and extends it to a general interconnection structure represented by a graph. A second main result allows one to accommodate state products. This extension makes the new stability criterion applicable to a broader class of models, even in the case of cyclic systems. The new stability test is illustrated on a mitogen activated protein kinase (MAPK) cascade model, and on a branched interconnection structure motivated by metabolic networks. Finally, another result addresses the robustness of stability in the presence of diffusion terms in a compartmental system made out of identical systems.Comment: See http://www.math.rutgers.edu/~sontag/PUBDIR/index.html for related (p)reprint

Design of Optimal Sparse Feedback Gains via the Alternating Direction Method of Multipliers

We design sparse and block sparse feedback gains that minimize the variance amplification (i.e., the $H_2$ norm) of distributed systems. Our approach consists of two steps. First, we identify sparsity patterns of feedback gains by incorporating sparsity-promoting penalty functions into the optimal control problem, where the added terms penalize the number of communication links in the distributed controller. Second, we optimize feedback gains subject to structural constraints determined by the identified sparsity patterns. In the first step, the sparsity structure of feedback gains is identified using the alternating direction method of multipliers, which is a powerful algorithm well-suited to large optimization problems. This method alternates between promoting the sparsity of the controller and optimizing the closed-loop performance, which allows us to exploit the structure of the corresponding objective functions. In particular, we take advantage of the separability of the sparsity-promoting penalty functions to decompose the minimization problem into sub-problems that can be solved analytically. Several examples are provided to illustrate the effectiveness of the developed approach.Comment: To appear in IEEE Trans. Automat. Contro