Machine Learning with Abstention for Automated Liver Disease Diagnosis

This paper presents a novel approach for detection of liver abnormalities in an automated manner using ultrasound images. For this purpose, we have implemented a machine learning model that can not only generate labels (normal and abnormal) for a given ultrasound image but it can also detect when its prediction is likely to be incorrect. The proposed model abstains from generating the label of a test example if it is not confident about its prediction. Such behavior is commonly practiced by medical doctors who, when given insufficient information or a difficult case, can chose to carry out further clinical or diagnostic tests before generating a diagnosis. However, existing machine learning models are designed in a way to always generate a label for a given example even when the confidence of their prediction is low. We have proposed a novel stochastic gradient based solver for the learning with abstention paradigm and use it to make a practical, state of the art method for liver disease classification. The proposed method has been benchmarked on a data set of approximately 100 patients from MINAR, Multan, Pakistan and our results show that the proposed scheme offers state of the art classification performance.Comment: Preprint version before submission for publication. complete version published in proc. 15th International Conference on Frontiers of Information Technology (FIT 2017), December 18-20, 2017, Islamabad, Pakistan. http://ieeexplore.ieee.org/document/8261064

Building Gene Expression Profile Classifiers with a Simple and Efficient Rejection Option in R

Background: The collection of gene expression profiles from DNA microarrays and their analysis with pattern recognition algorithms is a powerful technology applied to several biological problems. Common pattern recognition systems classify samples assigning them to a set of known classes. However, in a clinical diagnostics setup, novel and unknown classes (new pathologies) may appear and one must be able to reject those samples that do not fit the trained model. The problem of implementing a rejection option in a multi-class classifier has not been widely addressed in the statistical literature. Gene expression profiles represent a critical case study since they suffer from the curse of dimensionality problem that negatively reflects on the reliability of both traditional rejection models and also more recent approaches such as one-class classifiers. Results: This paper presents a set of empirical decision rules that can be used to implement a rejection option in a set of multi-class classifiers widely used for the analysis of gene expression profiles. In particular, we focus on the classifiers implemented in the R Language and Environment for Statistical Computing (R for short in the remaining of this paper). The main contribution of the proposed rules is their simplicity, which enables an easy integration with available data analysis environments. Since in the definition of a rejection model tuning of the involved parameters is often a complex and delicate task, in this paper we exploit an evolutionary strategy to automate this process. This allows the final user to maximize the rejection accuracy with minimum manual intervention. Conclusions: This paper shows how the use of simple decision rules can be used to help the use of complex machine learning algorithms in real experimental setups. The proposed approach is almost completely automated and therefore a good candidate for being integrated in data analysis flows in labs where the machine learning expertise required to tune traditional classifiers might not be availabl

The use of adversaries for optimal neural network training

B-decay data from the Belle experiment at the KEKB collider have a substantial background from $e^{+}e^{-}\to q \bar{q}$ events. To suppress this we employ deep neural network algorithms. These provide improved signal from background discrimination. However, the deep neural network develops a substantial correlation with the $\Delta E$ kinematic variable used to distinguish signal from background in the final fit due to its relationship with input variables. The effect of this correlation is reduced by deploying an adversarial neural network. Overall the adversarial deep neural network performs better than a Boosted Decision Tree algorithimn and a commercial package, NeuroBayes, which employs a neural net with a single hidden layer

Is Deep Learning Safe for Robot Vision? Adversarial Examples against the iCub Humanoid

Deep neural networks have been widely adopted in recent years, exhibiting impressive performances in several application domains. It has however been shown that they can be fooled by adversarial examples, i.e., images altered by a barely-perceivable adversarial noise, carefully crafted to mislead classification. In this work, we aim to evaluate the extent to which robot-vision systems embodying deep-learning algorithms are vulnerable to adversarial examples, and propose a computationally efficient countermeasure to mitigate this threat, based on rejecting classification of anomalous inputs. We then provide a clearer understanding of the safety properties of deep networks through an intuitive empirical analysis, showing that the mapping learned by such networks essentially violates the smoothness assumption of learning algorithms. We finally discuss the main limitations of this work, including the creation of real-world adversarial examples, and sketch promising research directions.Comment: Accepted for publication at the ICCV 2017 Workshop on Vision in Practice on Autonomous Robots (ViPAR