A gaze independent brain-computer interface based on visual stimulation through closed eyelids

A classical brain-computer interface (BCI) based on visual event-related potentials (ERPs) is of limited application value for paralyzed patients with severe oculomotor impairments. In this study, we introduce a novel gaze independent BCI paradigm that can be potentially used for such end-users because visual stimuli are administered on closed eyelids. The paradigm involved verbally presented questions with 3 possible answers. Online BCI experiments were conducted with twelve healthy subjects, where they selected one option by attending to one of three different visual stimuli. It was confirmed that typical cognitive ERPs can be evidently modulated by the attention of a target stimulus in eyes-closed and gaze independent condition and further classified with high accuracy during online operation (74.58% ± 17.85 s.d.; chance level 33.33%), demonstrating the effectiveness of the proposed novel visual ERP paradigm. Also, stimulus-specific eye movements observed during stimulation were verified as reflex responses to light stimuli and they did not contribute to classification. To the best of our knowledge, this study is the first to show the possibility of using a gaze independent visual ERP paradigm in an eyes-closed condition, thereby providing another communication option for severely locked-in patients suffering from complex ocular dysfunctions.BMBF, 01GQ0850, Bernstein Fokus Neurotechnologie - Nichtinvasive Neurotechnologie für Mensch-Maschine InteraktionBMBF, 16SV5839, Maschinelles Lernen zur Optimierung der Kommunikation schwerstgelähmter Patienten per BC

Classification of Frequency and Phase Encoded Steady State Visual Evoked Potentials for Brain Computer Interface Speller Applications using Convolutional Neural Networks

Over the past decade there have been substantial improvements in vision based Brain-Computer Interface (BCI) spellers for quadriplegic patient populations. This thesis contains a review of the numerous bio-signals available to BCI researchers, as well as a brief chronology of foremost decoding methodologies used to date. Recent advances in classification accuracy and information transfer rate can be primarily attributed to time consuming patient specific parameter optimization procedures. The aim of the current study was to develop analysis software with potential ‘plug-in-and-play’ functionality. To this end, convolutional neural networks, presently established as state of the art analytical techniques for image processing, were utilized. The thesis herein defines deep convolutional neural network architecture for the offline classification of phase and frequency encoded SSVEP bio-signals. Networks were trained using an extensive 35 participant open source Electroencephalographic (EEG) benchmark dataset (Department of Bio-medical Engineering, Tsinghua University, Beijing). Average classification accuracies of 82.24% and information transfer rates of 22.22 bpm were achieved on a BCI naïve participant dataset for a 40 target alphanumeric display, in absence of any patient specific parameter optimization

On Tackling Fundamental Constraints in Brain-Computer Interface Decoding via Deep Neural Networks

A Brain-Computer Interface (BCI) is a system that provides a communication and control medium between human cortical signals and external devices, with the primary aim to assist or to be used by patients who suffer from a neuromuscular disease. Despite significant recent progress in the area of BCI, there are numerous shortcomings associated with decoding Electroencephalography-based BCI signals in real-world environments. These include, but are not limited to, the cumbersome nature of the equipment, complications in collecting large quantities of real-world data, the rigid experimentation protocol and the challenges of accurate signal decoding, especially in making a system work in real-time. Hence, the core purpose of this work is to investigate improving the applicability and usability of BCI systems, whilst preserving signal decoding accuracy. Recent advances in Deep Neural Networks (DNN) provide the possibility for signal processing to automatically learn the best representation of a signal, contributing to improved performance even with a noisy input signal. Subsequently, this thesis focuses on the use of novel DNN-based approaches for tackling some of the key underlying constraints within the area of BCI. For example, recent technological improvements in acquisition hardware have made it possible to eliminate the pre-existing rigid experimentation procedure, albeit resulting in noisier signal capture. However, through the use of a DNN-based model, it is possible to preserve the accuracy of the predictions from the decoded signals. Moreover, this research demonstrates that by leveraging DNN-based image and signal understanding, it is feasible to facilitate real-time BCI applications in a natural environment. Additionally, the capability of DNN to generate realistic synthetic data is shown to be a potential solution in reducing the requirement for costly data collection. Work is also performed in addressing the well-known issues regarding subject bias in BCI models by generating data with reduced subject-specific features. The overall contribution of this thesis is to address the key fundamental limitations of BCI systems. This includes the unyielding traditional experimentation procedure, the mandatory extended calibration stage and sustaining accurate signal decoding in real-time. These limitations lead to a fragile BCI system that is demanding to use and only suited for deployment in a controlled laboratory. Overall contributions of this research aim to improve the robustness of BCI systems and enable new applications for use in the real-world

A hybrid environment control system combining EMG and SSVEP signal based on brain-computer interface technology

The patients who are impaired with neurodegenerative disorders cannot command their muscles through the neural pathways. These patients are given an alternative from their neural path through Brain-Computer Interface (BCI) systems, which are the explicit use of brain impulses without any need for a computer's vocal muscle. Nowadays, the steady-state visual evoked potential (SSVEP) modality offers a robust communication pathway to introduce a non-invasive BCI. There are some crucial constituents, including window length of SSVEP response, the number of electrodes in the acquisition device and system accuracy, which are the critical performance components in any BCI system based on SSVEP signal. In this study, a real-time hybrid BCI system consists of SSVEP and EMG has been proposed for the environmental control system. The feature in terms of the common spatial pattern (CSP) has been extracted from four classes of SSVEP response, and extracted feature has been classified using K-nearest neighbors (k-NN) based classification algorithm. The obtained classification accuracy of eight participants was 97.41%. Finally, a control mechanism that aims to apply for the environmental control system has also been developed. The proposed system can identify 18 commands (i.e., 16 control commands using SSVEP and two commands using EMG). This result represents very encouraging performance to handle real-time SSVEP based BCI system consists of a small number of electrodes. The proposed framework can offer a convenient user interface and a reliable control method for realistic BCI technology

The Berlin Brain–Computer Interface: Non-Medical Uses of BCI Technology

Brain–computer interfacing (BCI) is a steadily growing area of research. While initially BCI research was focused on applications for paralyzed patients, increasingly more alternative applications in healthy human subjects are proposed and investigated. In particular, monitoring of mental states and decoding of covert user states have seen a strong rise of interest. Here, we present some examples of such novel applications which provide evidence for the promising potential of BCI technology for non-medical uses. Furthermore, we discuss distinct methodological improvements required to bring non-medical applications of BCI technology to a diversity of layperson target groups, e.g., ease of use, minimal training, general usability, short control latencies

Towards an SSVEP Based BCI With High ITR

A brain-computer interface (BCI) provides the possibility to translate brain neural activity patterns into control commands without movement by the user. In recent years, there has been increasing interest in using steady-state visual evoked potential (SSVEP) in BCI systems; the SSVEP approach provides currently the fastest and most reliable communication paradigm for the implementation of a non-invasive BCI system. However, many aspects of current system realizations need improvement, specifically in relation to speed (in terms of information transfer rate as well as time needed to perform a single command), user variability and ease of use. With these improvements in mind, this paper presents the Bremen-BCI, an online multi-channel SSVEP-based BCI system that operates on a conventional computer making use of the minimum energy combination method for extraction of power information associated with the SSVEP responses. An additional advantage of the presented methodology is that it is fully online, i.e., no calibration data for noise estimation, feature extraction, or electrode selection is needed, the system is ready to use once the subject is prepared. The SSVEP-based Bremen-BCI system with five targets, an adaptive time segment length between 0.75s and 4s, and six EEG channel locations on the occipital area, was used for online testing on 27 subjects. ALL participants were able to successfully complete spelling tasks with a mean accuracy of 93.83% and an information transfer rate (ITR) of 49.93 bit/min

EEG dataset and OpenBMI toolbox for three BCI paradigms: an investigation into BCI illiteracy

https://academic.oup.com/gigascience/article/8/5/giz002/5304369Background Electroencephalography (EEG)-based brain-computer interface (BCI) systems are mainly divided into three major paradigms: motor imagery (MI), event-related potential (ERP), and steady-state visually evoked potential (SSVEP). Here, we present a BCI dataset that includes the three major BCI paradigms with a large number of subjects over multiple sessions. In addition, information about the psychological and physiological conditions of BCI users was obtained using a questionnaire, and task-unrelated parameters such as resting state, artifacts, and electromyography of both arms were also recorded. We evaluated the decoding accuracies for the individual paradigms and determined performance variations across both subjects and sessions. Furthermore, we looked for more general, severe cases of BCI illiteracy than have been previously reported in the literature. Results Average decoding accuracies across all subjects and sessions were 71.1% (± 0.15), 96.7% (± 0.05), and 95.1% (± 0.09), and rates of BCI illiteracy were 53.7%, 11.1%, and 10.2% for MI, ERP, and SSVEP, respectively. Compared to the ERP and SSVEP paradigms, the MI paradigm exhibited large performance variations between both subjects and sessions. Furthermore, we found that 27.8% (15 out of 54) of users were universally BCI literate, i.e., they were able to proficiently perform all three paradigms. Interestingly, we found no universally illiterate BCI user, i.e., all participants were able to control at least one type of BCI system. Conclusions Our EEG dataset can be utilized for a wide range of BCI-related research questions. All methods for the data analysis in this study are supported with fully open-source scripts that can aid in every step of BCI technology. Furthermore, our results support previous but disjointed findings on the phenomenon of BCI illiteracy

MEDUSA©: A novel Python-based software ecosystem to accelerate brain-computer interface and cognitive neuroscience research

Producción CientíficaBackground and objective. Neurotechnologies have great potential to transform our society in ways that are yet to be uncovered. The rate of development in this field has increased significantly in recent years, but there are still barriers that need to be overcome before bringing neurotechnologies to the general public. One of these barriers is the difficulty of performing experiments that require complex software, such as brain-computer interfaces (BCI) or cognitive neuroscience experiments. Current platforms have limitations in terms of functionality and flexibility to meet the needs of researchers, who often need to implement new experimentation settings. This work was aimed to propose a novel software ecosystem, called MEDUSA©, to overcome these limitations. Methods. We followed strict development practices to optimize MEDUSA© for research in BCI and cognitive neuroscience, making special emphasis in the modularity, flexibility and scalability of our solution. Moreover, it was implemented in Python, an open-source programming language that reduces the development cost by taking advantage from its high-level syntax and large number of community packages. Results. MEDUSA© provides a complete suite of signal processing functions, including several deep learning architectures or connectivity analysis, and ready-to-use BCI and neuroscience experiments, making it one of the most complete solutions nowadays. We also put special effort in providing tools to facilitate the development of custom experiments, which can be easily shared with the community through an app market available in our website to promote reproducibility. Conclusions. MEDUSA© is a novel software ecosystem for modern BCI and neurotechnology experimentation that provides state-of-the-art tools and encourages the participation of the community to make a difference for the progress of these fields. Visit the official website at https://www.medusabci.com/ to know more about this project.Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación/10.13039/501100011033/' y el Fondo Europeo de Desarrollo Regional (FEDER) grants (PID2020-115468RB-I00 and RTC2019-007350-1