A Detailed Investigation into Low-Level Feature Detection in Spectrogram Images

Being the first stage of analysis within an image, low-level feature detection is a crucial step in the image analysis process and, as such, deserves suitable attention. This paper presents a systematic investigation into low-level feature detection in spectrogram images. The result of which is the identification of frequency tracks. Analysis of the literature identifies different strategies for accomplishing low-level feature detection. Nevertheless, the advantages and disadvantages of each are not explicitly investigated. Three model-based detection strategies are outlined, each extracting an increasing amount of information from the spectrogram, and, through ROC analysis, it is shown that at increasing levels of extraction the detection rates increase. Nevertheless, further investigation suggests that model-based detection has a limitation—it is not computationally feasible to fully evaluate the model of even a simple sinusoidal track. Therefore, alternative approaches, such as dimensionality reduction, are investigated to reduce the complex search space. It is shown that, if carefully selected, these techniques can approach the detection rates of model-based strategies that perform the same level of information extraction. The implementations used to derive the results presented within this paper are available online from http://stdetect.googlecode.com

High Dimensional Data Set Analysis Using a Large-Scale Manifold Learning Approach

Because of technological advances, a trend occurs for data sets increasing in size and dimensionality. Processing these large scale data sets is challenging for conventional computers due to computational limitations. A framework for nonlinear dimensionality reduction on large databases is presented that alleviates the issue of large data sets through sampling, graph construction, manifold learning, and embedding. Neighborhood selection is a key step in this framework and a potential area of improvement. The standard approach to neighborhood selection is setting a fixed neighborhood. This could be a fixed number of neighbors or a fixed neighborhood size. Each of these has its limitations due to variations in data density. A novel adaptive neighbor-selection algorithm is presented to enhance performance by incorporating sparse ℓ 1-norm based optimization. These enhancements are applied to the graph construction and embedding modules of the original framework. As validation of the proposed ℓ1-based enhancement, experiments are conducted on these modules using publicly available benchmark data sets. The two approaches are then applied to a large scale magnetic resonance imaging (MRI) data set for brain tumor progression prediction. Results showed that the proposed approach outperformed linear methods and other traditional manifold learning algorithms

Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Principal Component Analysis

This book is aimed at raising awareness of researchers, scientists and engineers on the benefits of Principal Component Analysis (PCA) in data analysis. In this book, the reader will find the applications of PCA in fields such as image processing, biometric, face recognition and speech processing. It also includes the core concepts and the state-of-the-art methods in data analysis and feature extraction

Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data

<p>Abstract</p> <p>Background</p> <p>Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduction and classification are considerable challenges in statistical machine learning. We therefore propose a novel approach for dimensionality reduction and tested it using published high-resolution SELDI-TOF data for ovarian cancer.</p> <p>Results</p> <p>We propose a method based on statistical moments to reduce feature dimensions. After refining and <it>t</it>-testing, SELDI-TOF data are divided into several intervals. Four statistical moments (mean, variance, skewness and kurtosis) are calculated for each interval and are used as representative variables. The high dimensionality of the data can thus be rapidly reduced. To improve efficiency and classification performance, the data are further used in kernel PLS models. The method achieved average sensitivity of 0.9950, specificity of 0.9916, accuracy of 0.9935 and a correlation coefficient of 0.9869 for 100 five-fold cross validations. Furthermore, only one control was misclassified in leave-one-out cross validation.</p> <p>Conclusion</p> <p>The proposed method is suitable for analyzing high-throughput proteomics data.</p

Improved data visualisation through nonlinear dissimilarity modelling

Inherent to state-of-the-art dimension reduction algorithms is the assumption that global distances between observations are Euclidean, despite the potential for altogether non-Euclidean data manifolds. We demonstrate that a non-Euclidean manifold chart can be approximated by implementing a universal approximator over a dictionary of dissimilarity measures, building on recent developments in the field. This approach is transferable across domains such that observations can be vectors, distributions, graphs and time series for instance. Our novel dissimilarity learning method is illustrated with four standard visualisation datasets showing the benefits over the linear dissimilarity learning approach