One-Class Classification: Taxonomy of Study and Review of Techniques

One-class classification (OCC) algorithms aim to build classification models when the negative class is either absent, poorly sampled or not well defined. This unique situation constrains the learning of efficient classifiers by defining class boundary just with the knowledge of positive class. The OCC problem has been considered and applied under many research themes, such as outlier/novelty detection and concept learning. In this paper we present a unified view of the general problem of OCC by presenting a taxonomy of study for OCC problems, which is based on the availability of training data, algorithms used and the application domains applied. We further delve into each of the categories of the proposed taxonomy and present a comprehensive literature review of the OCC algorithms, techniques and methodologies with a focus on their significance, limitations and applications. We conclude our paper by discussing some open research problems in the field of OCC and present our vision for future research.Comment: 24 pages + 11 pages of references, 8 figure

Predicting breast cancer risk, recurrence and survivability

This thesis focuses on predicting breast cancer at early stages by using machine learning algorithms based on biological datasets. The accuracy of those algorithms has been improved to enable the physicians to enhance the success of treatment, thus saving lives and avoiding several further medical tests

Predictive Modelling Approach to Data-Driven Computational Preventive Medicine

This thesis contributes novel predictive modelling approaches to data-driven computational preventive medicine and offers an alternative framework to statistical analysis in preventive medicine research. In the early parts of this research, this thesis presents research by proposing a synergy of machine learning methods for detecting patterns and developing inexpensive predictive models from healthcare data to classify the potential occurrence of adverse health events. In particular, the data-driven methodology is founded upon a heuristic-systematic assessment of several machine-learning methods, data preprocessing techniques, models’ training estimation and optimisation, and performance evaluation, yielding a novel computational data-driven framework, Octopus. Midway through this research, this thesis advances research in preventive medicine and data mining by proposing several new extensions in data preparation and preprocessing. It offers new recommendations for data quality assessment checks, a novel multimethod imputation (MMI) process for missing data mitigation, a novel imbalanced resampling approach, and minority pattern reconstruction (MPR) led by information theory. This thesis also extends the area of model performance evaluation with a novel classification performance ranking metric called XDistance. In particular, the experimental results show that building predictive models with the methods guided by our new framework (Octopus) yields domain experts' approval of the new reliable models’ performance. Also, performing the data quality checks and applying the MMI process led healthcare practitioners to outweigh predictive reliability over interpretability. The application of MPR and its hybrid resampling strategies led to better performances in line with experts' success criteria than the traditional imbalanced data resampling techniques. Finally, the use of the XDistance performance ranking metric was found to be more effective in ranking several classifiers' performances while offering an indication of class bias, unlike existing performance metrics The overall contributions of this thesis can be summarised as follow. First, several data mining techniques were thoroughly assessed to formulate the new Octopus framework to produce new reliable classifiers. In addition, we offer a further understanding of the impact of newly engineered features, the physical activity index (PAI) and biological effective dose (BED). Second, the newly developed methods within the new framework. Finally, the newly accepted developed predictive models help detect adverse health events, namely, visceral fat-associated diseases and advanced breast cancer radiotherapy toxicity side effects. These contributions could be used to guide future theories, experiments and healthcare interventions in preventive medicine and data mining

Intelligent Computing for Big Data

Recent advances in artificial intelligence have the potential to further develop current big data research. The Special Issue on ‘Intelligent Computing for Big Data’ highlighted a number of recent studies related to the use of intelligent computing techniques in the processing of big data for text mining, autism diagnosis, behaviour recognition, and blockchain-based storage

Single-Nucleosome Mapping of Histone Modifications in S. cerevisiae

Covalent modification of histone proteins plays a role in virtually every process on eukaryotic DNA, from transcription to DNA repair. Many different residues can be covalently modified, and it has been suggested that these modifications occur in a great number of independent, meaningful combinations. Published low-resolution microarray studies on the combinatorial complexity of histone modification patterns suffer from confounding effects caused by the averaging of modification levels over multiple nucleosomes. To overcome this problem, we used a high-resolution tiled microarray with single-nucleosome resolution to investigate the occurrence of combinations of 12 histone modifications on thousands of nucleosomes in actively growing S. cerevisiae. We found that histone modifications do not occur independently; there are roughly two groups of co-occurring modifications. One group of lysine acetylations shows a sharply defined domain of two hypo-acetylated nucleosomes, adjacent to the transcriptional start site, whose occurrence does not correlate with transcription levels. The other group consists of modifications occurring in gradients through the coding regions of genes in a pattern associated with transcription. We found no evidence for a deterministic code of many discrete states, but instead we saw blended, continuous patterns that distinguish nucleosomes at one location (e.g., promoter nucleosomes) from those at another location (e.g., over the 3′ ends of coding regions). These results are consistent with the idea of a simple, redundant histone code, in which multiple modifications share the same role

Learning with Low-Quality Data: Multi-View Semi-Supervised Learning with Missing Views

The focus of this thesis is on learning approaches for what we call ``low-quality data'' and in particular data in which only small amounts of labeled target data is available. The first part provides background discussion on low-quality data issues, followed by preliminary study in this area. The remainder of the thesis focuses on a particular scenario: multi-view semi-supervised learning. Multi-view learning generally refers to the case of learning with data that has multiple natural views, or sets of features, associated with it. Multi-view semi-supervised learning methods try to exploit the combination of multiple views along with large amounts of unlabeled data in order to learn better predictive functions when limited labeled data is available. However, lack of complete view data limits the applicability of multi-view semi-supervised learning to real world data. Commonly, one data view is readily and cheaply available, but additionally views may be costly or only available in some cases. This thesis work aims to make multi-view semi-supervised learning approaches more applicable to real world data specifically by addressing the issue of missing views through both feature generation and active learning, and addressing the issue of model selection for semi-supervised learning with limited labeled data. This thesis introduces a unified approach for handling missing view data in multi-view semi-supervised learning tasks, which applies to both data with completely missing additional views and data only missing views in some instances. The idea is to learn a feature generation function mapping one view to another with the mapping biased to encourage the features generated to be useful for multi-view semi-supervised learning algorithms. The mapping is then used to fill in views as pre-processing. Unlike previously proposed single-view multi-view learning approaches, the proposed approach is able to take advantage of additional view data when available, and for the case of partial view presence is the first feature-generation approach specifically designed to take into account the multi-view semi-supervised learning aspect. The next component of this thesis is the analysis of an active view completion scenario. In some tasks, it is possible to obtain missing view data for a particular instance, but with some associated cost. Recent work has shown an active selection strategy can be more effective than a random one. In this thesis, a better understanding of active approaches is sought, and it is demonstrated that the effectiveness of an active selection strategy over a random one can depend on the relationship between the views. Finally, an important component of making multi-view semi-supervised learning applicable to real world data is the task of model selection, an open problem which is often avoided entirely in previous work. For cases of very limited labeled training data the commonly used cross-validation approach can become ineffective. This thesis introduces a re-training alternative to the method-dependent approaches similar in motivation to cross-validation, that involves generating new training and test data by sampling from the large amount of unlabeled data and estimated conditional probabilities for the labels. The proposed approaches are evaluated on a variety of multi-view semi-supervised learning data sets, and the experimental results demonstrate their efficacy

Click Fraud Detection in Online and In-app Advertisements: A Learning Based Approach

Click Fraud is the fraudulent act of clicking on pay-per-click advertisements to increase a site’s revenue, to drain revenue from the advertiser, or to inflate the popularity of content on social media platforms. In-app advertisements on mobile platforms are among the most common targets for click fraud, which makes companies hesitant to advertise their products. Fraudulent clicks are supposed to be caught by ad providers as part of their service to advertisers, which is commonly done using machine learning methods. However: (1) there is a lack of research in current literature addressing and evaluating the different techniques of click fraud detection and prevention, (2) threat models composed of active learning systems (smart attackers) can mislead the training process of the fraud detection model by polluting the training data, (3) current deep learning models have significant computational overhead, (4) training data is often in an imbalanced state, and balancing it still results in noisy data that can train the classifier incorrectly, and (5) datasets with high dimensionality cause increased computational overhead and decreased classifier correctness -- while existing feature selection techniques address this issue, they have their own performance limitations. By extending the state-of-the-art techniques in the field of machine learning, this dissertation provides the following solutions: (i) To address (1) and (2), we propose a hybrid deep-learning-based model which consists of an artificial neural network, auto-encoder and semi-supervised generative adversarial network. (ii) As a solution for (3), we present Cascaded Forest and Extreme Gradient Boosting with less hyperparameter tuning. (iii) To overcome (4), we propose a row-wise data reduction method, KSMOTE, which filters out noisy data samples both in the raw data and the synthetically generated samples. (iv) For (5), we propose different column-reduction methods such as multi-time-scale Time Series analysis for fraud forecasting, using binary labeled imbalanced datasets and hybrid filter-wrapper feature selection approaches