Development and deployment of a microfluidic platform for water quality monitoring

There is an increasing demand for autonomous sensor devices which can provide reliable data on key water quality parameters at a higher temporal and geographical resolution than is achievable using current approaches to sampling and monitoring. Microfluidic technology, in combination with rapid and on-going developments in the area of wireless communications, has significant potential to address this demand due to a number of advantageous features which allow the development of compact, low-cost and low-powered analytical devices. Here we report on the development of a microfluidic platform for water quality monitoring. This system has been successfully applied to in-situ monitoring of phosphate in environmental and wastewater monitoring applications. We describe a number of the technical and practical issues encountered and addressed during these deployments and summarise the current status of the technology

PHALANX: Expendable Projectile Sensor Networks for Planetary Exploration

Technologies enabling long-term, wide-ranging measurement in hard-to-reach areas are a critical need for planetary science inquiry. Phenomena of interest include flows or variations in volatiles, gas composition or concentration, particulate density, or even simply temperature. Improved measurement of these processes enables understanding of exotic geologies and distributions or correlating indicators of trapped water or biological activity. However, such data is often needed in unsafe areas such as caves, lava tubes, or steep ravines not easily reached by current spacecraft and planetary robots. To address this capability gap, we have developed miniaturized, expendable sensors which can be ballistically lobbed from a robotic rover or static lander - or even dropped during a flyover. These projectiles can perform sensing during flight and after anchoring to terrain features. By augmenting exploration systems with these sensors, we can extend situational awareness, perform long-duration monitoring, and reduce utilization of primary mobility resources, all of which are crucial in surface missions. We call the integrated payload that includes a cold gas launcher, smart projectiles, planning software, network discovery, and science sensing: PHALANX. In this paper, we introduce the mission architecture for PHALANX and describe an exploration concept that pairs projectile sensors with a rover mothership. Science use cases explored include reconnaissance using ballistic cameras, volatiles detection, and building timelapse maps of temperature and illumination conditions. Strategies to autonomously coordinate constellations of deployed sensors to self-discover and localize with peer ranging (i.e. a local GPS) are summarized, thus providing communications infrastructure beyond-line-of-sight (BLOS) of the rover. Capabilities were demonstrated through both simulation and physical testing with a terrestrial prototype. The approach to developing a terrestrial prototype is discussed, including design of the launching mechanism, projectile optimization, micro-electronics fabrication, and sensor selection. Results from early testing and characterization of commercial-off-the-shelf (COTS) components are reported. Nodes were subjected to successful burn-in tests over 48 hours at full logging duty cycle. Integrated field tests were conducted in the Roverscape, a half-acre planetary analog environment at NASA Ames, where we tested up to 10 sensor nodes simultaneously coordinating with an exploration rover. Ranging accuracy has been demonstrated to be within +/-10cm over 20m using commodity radios when compared to high-resolution laser scanner ground truthing. Evolution of the design, including progressive miniaturization of the electronics and iterated modifications of the enclosure housing for streamlining and optimized radio performance are described. Finally, lessons learned to date, gaps toward eventual flight mission implementation, and continuing future development plans are discussed

Mechanics and applications of stretchable serpentine structures

Stretchable structures have been developed for various applications, including expandable coronary stents, deployable sensor networks and stretchable bio-mimetic and bio-integrated electronics. High-performance, stretchable electronics have to utilize high-quality and long-lasting inorganic electronic materials such as silicon, oxide dielectrics and metals, which are intrinsically stiff and often brittle. It is therefore an interdisciplinary challenge to make inorganic electronics stretchable while retaining their electronic functionality. Patterning stiff materials into serpentine-shaped wavy ribbons has become a popular strategy for fabricating stretchable inorganic electronics. However due to a lack of mechanics understanding, design of serpentine structures is still largely empirical, whether for freestanding or substrate supported serpentines. This dissertation systematically investigates the mechanics of serpentine structures with emphasis on the effects of serpentine geometry and substrate stiffness, which involves theoretical analysis, numerical simulation, and experimental validation. Our theory has successfully predicted the stretchability and stiffness of various serpentine shapes and has been applied to the optimization of serpentine designs under practical constraints. We are also the first to point out that not all geometric effects are monotonic and serpentines are not always more stretchable than linear ribbons. To manufacture high quality serpentine ribbons with high throughput and low cost, we have invented a “cut-and-paste” method to fabricate both metallic and ceramic serpentines. As a demonstration of our method, a noninvasive, tattoo-like multifunctional epidermal sensor system has been built for the measurement of electrophysiological signals, skin temperature, skin hydration, and respiratory rate. Engineering of epidermal stretchable antenna for wireless communication is also detailed and rationalized.Mechanical Engineerin

Advances in materials strategies, circuit designs, and informatics for wearable, flexible and stretchable electronics with medical and robotic applications

The future of medical electronics should be flexible, stretchable and skin-integrated. While modern electronics become increasing smaller, faster and energy efficient, the designs remain bulky and rigid due to materials and processing limitations. The miniaturization of health monitoring devices in wearable form resembles a significant progress towards the next-generation medical electronics. However, there are still key challenges in these wearable electronics associated with medical-grade sensing precision, reliable wireless powering, and materials strategy for skin-integration. Here, I present a series of systematic studies from materials strategies, circuit design to signal processing on skin-mounted electronic wearable devices. Several types of Epidermal Electronic Systems (EES) develop applications in dermatology, cardiology, rehabilitation, and wireless powering. For skin hydration measurement, fundamental studies of electrode configurations and skin-electrode impedance reveal the optimal sensor design. Furthermore, wireless operation of hydration sensor was made possible with direct integration on skin, and on porous substrates that collect and analyze sweats. Additionally, I present an epidermal multi-functional sensing platform that could provide a control-feedback loop through electromyogram and current stimulation; and a mechano-acoustic device that could capture vibrations from muscle, heart, and throat as diagnostic tools or human-machine interface. I developed a modularized epidermal radio-frequency energy transfer epidermal device to eliminate batteries and power cables for wearable electronics. Finally, I present a clinical study that validates a commercialized ESS on patients with nerve disorders for electromyography monitoring during peripheral nerve and spinal cord surgeries

Skin-Integrated wearable systems and implantable biosensors: a comprehensive review

Biosensors devices have attracted the attention of many researchers across the world. They have the capability to solve a large number of analytical problems and challenges. They are future ubiquitous devices for disease diagnosis, monitoring, treatment and health management. This review presents an overview of the biosensors field, highlighting the current research and development of bio-integrated and implanted biosensors. These devices are micro- and nano-fabricated, according to numerous techniques that are adapted in order to offer a suitable mechanical match of the biosensor to the surrounding tissue, and therefore decrease the body’s biological response. For this, most of the skin-integrated and implanted biosensors use a polymer layer as a versatile and flexible structural support, combined with a functional/active material, to generate, transmit and process the obtained signal. A few challenging issues of implantable biosensor devices, as well as strategies to overcome them, are also discussed in this review, including biological response, power supply, and data communication.This research was funded by FCT- FUNDAÇÃO PARA A CIÊNCIA E TECNOLOGIA, grant numbers: PTDC/EMD-EMD/31590/2017 and PTDC/BTM-ORG/28168/2017

연성 및 생재흡수성 전자소자용 비휘발성 메모리 소자와 집적센서 구현

학위논문 (박사)-- 서울대학교 대학원 : 화학생물공학부, 2015. 8. 김대형.Over years, major advances in healthcare have been made through research in the fields of nanomaterials and microelectronics technologies. However, the mechanical and geometrical constraints inherent in the standard forms of rigid electronics have imposed challanges of unique integration and therapeutic delivery in non-invasive and minimally invasive medical devices. Here, we describe two types of multifunctional electronic systems. The first type is wearable-on-the-skin systems that address the challenges via monolithic integration of nanomembranes fabricated by top-down approach, nanotubes and nanoparticles assembled by bottom-up strategies, and stretchable electronics on tissue-like polymeric substrate. The system consists of physiological sensors, non-volatile memory, logic gates, and drug-release actuators. Some quantitative analyses on the operation of each electronics, mechanics, heat-transfer, and drug-diffusion characteristic validated their system-level multi-functionalities. The second type is a bioresorbable electronic stent with drug-infused functionalized nanoparticles that takes flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and photothermal therapy. In vivo and ex vivo animal experiments as well as in vitro cell researches demonstrate its unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system. As demonstrations of these technologies, we herein highlight two representative examples of multifunctional systems in order of increasing degree of invasiveness: electronically enabled wearable patch and endovascular electronic stent that incorporate onboard physiological monitoring, data storage, and therapy under moist and mechanically rigorous conditions.Contents Abstract Chapter 1. Introduction 1.1 Organic flexible and wearable electronics.................................................. 1 1.2 Inorganic flexible and wearable electronics............................................... 14 1.3 Flexible non-volatile memory devices.......................................................... 25 1.4 Bioresorbable materials and devices........................................................... 34 References Chapter 2. Multifunctional wearable devices for diagnosis and therapy of movement disorders 2.1 Introduction ................................................................................. 45 2.2 Experimental Section ......................................................................... 49 2.3 Result and Discussion ........................................................................ 65 2.4 Conclusion ................................................................................... 95 References Chapter 3. Stretchable Carbon Nanotube Charge-Trap Floating-Gate Memory and Logic Devices for Wearable Electronics 3.1 Introduction ................................................................................ 101 3.2 Experimental Section ........................................................................ 104 3.3 Result and Discussion ....................................................................... 107 3.4 Conclusion .................................................................................. 138 References Chapter 4. Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases 4.1 Introduction ................................................................................ 148 4.2 Experimental Section ........................................................................ 151 4.3 Result and Discussion ....................................................................... 173 4.4 Conclusion .................................................................................. 219 References 국문 초록 (Abstract in Korean) .................................................................. 230Docto

The NASA SBIR product catalog

The purpose of this catalog is to assist small business firms in making the community aware of products emerging from their efforts in the Small Business Innovation Research (SBIR) program. It contains descriptions of some products that have advanced into Phase 3 and others that are identified as prospective products. Both lists of products in this catalog are based on information supplied by NASA SBIR contractors in responding to an invitation to be represented in this document. Generally, all products suggested by the small firms were included in order to meet the goals of information exchange for SBIR results. Of the 444 SBIR contractors NASA queried, 137 provided information on 219 products. The catalog presents the product information in the technology areas listed in the table of contents. Within each area, the products are listed in alphabetical order by product name and are given identifying numbers. Also included is an alphabetical listing of the companies that have products described. This listing cross-references the product list and provides information on the business activity of each firm. In addition, there are three indexes: one a list of firms by states, one that lists the products according to NASA Centers that managed the SBIR projects, and one that lists the products by the relevant Technical Topics utilized in NASA's annual program solicitation under which each SBIR project was selected

Pop-Up Stretchable Sensor Designs Using Multiphysics Modeliing

Stretchable electronic devices are critical for the future of wearable sensor technology, where existing rigid and non-flexible devices severely limit the applicability of them in many areas. Stretchable electronics extend flexible electronics one step further by introducing significant elastic deformation. Stretchable electronics can conform to curvy geometries like human skin which enables new applications such as fully wearable electronics whose properties can be tuned through mechanical deformation. Much of the effort in stretchable electronics has focused on investigation of the optimum fabrication method to make a trade-off between the manufacturing cost and acceptable performance. Here in this thesis a novel pop-up strain sensor design is introduced and tested.This technique is simple to use and can be applied to almost all available materials such as metals, dielectrics, semiconductors and different scales from centi-meter to nanoscale. Using this method three main electronic devices have been designed for different applications. The first category is pop-up antennas that are able to reconfigure their frequency response with respect to the mechanical deformation by out of plane displacement. The second category is pop-up frequency selective surface which similarly can change its frequency behaviour due to applied strain. This ability to accommodate the applied stress by three-dimensional (3D) deformation, making these devices ideal for strain sensing applications such as vapor sensing or on skin mountable sensors. Using the advantage of RFID technology in terms of wireless monitoring, the third category has been introduced which is a pop-up capacitor sensor integrating with an RFID chip to detect finger joint bending that can help those patients who are recovering after stroke. The proposed devices have been modelled using COMSOL Multiphysics and Extensive evaluations of the prototype system were conducted on purpose-built laboratory scale test rigs. Both results are in good correlation which makes them applicable for sensing purposes

Antenna sensing for wearable applications

As wearable technologies are growing fast, there is emerging trend to increase functionality of the devices. Antennas which are primarily component in communication systems can offer attractive route forward to minimize the number of components functioning as a sensing element for wearable and flexible electronics. Toward development of flexible antenna as sensing element, this thesis investigates the development of the flexible and printed sensing NFC RFID tag. In this approach, the sensor measurement is supported by the internal sensor and analog-to-digital convertor (ADC) of the NFC transponder. Design optimisation, fabrication and characterization of the printed antenna are described. Besides, the printed antenna, NFC transponder and two simple resistive sensors are integrated to form a fully flexible sensing RFID tag demonstrating applicability in food and health monitoring. This thesis also presents development of two antenna sensors by using functional materials: (i) An inductor-capacitor (LC) resonant tank based wireless pressure sensor on electrospun Poly-L-lactide (PLLA) nanofibers-based substrate. The screen-printed resonant tank (resonant frequency of ~13.56 MHz) consists of a planar inductor connected in parallel with an interdigitated capacitor. Since the substrates is piezoelectric, the capacitance of the interdigitated capacitor varies in response to the applied pressure. To demonstrate a potential application of developed pressure sensor, it was integrated on a compression bandage to monitor sub-bandage pressure. (ii) To investigate the realization of sensing antenna as temperature sensor simple loop antenna is designed and in this study unlike the first study that the sensing element was the substrate, the conductive body of the antenna itself is considered as a functional material. In this case, a small part of a loop antenna which originally was printed using silver paste is replaced by Poly(3,4-ethylenedioxythiophene): polystyrene (PEDOT: PSS). The sensing mechanism is based on the resonant frequency shift by varying temperature. While using functional materials is useful for realization of antenna sensor, another approach also is presented by developing stretchable textile-based microstrip antennas on deformable substrate which can measure joint angles of a human limb. The EM characteristics of the meshed patch antenna were compared with its metallic counterpart fabricated with lithography technique. Moreover, the concept of stretchable UHF RFID-based strain sensor is touched in the final part of this thesis