A niching memetic algorithm for simultaneous clustering and feature selection

Clustering is inherently a difficult task, and is made even more difficult when the selection of relevant features is also an issue. In this paper we propose an approach for simultaneous clustering and feature selection using a niching memetic algorithm. Our approach (which we call NMA_CFS) makes feature selection an integral part of the global clustering search procedure and attempts to overcome the problem of identifying less promising locally optimal solutions in both clustering and feature selection, without making any a priori assumption about the number of clusters. Within the NMA_CFS procedure, a variable composite representation is devised to encode both feature selection and cluster centers with different numbers of clusters. Further, local search operations are introduced to refine feature selection and cluster centers encoded in the chromosomes. Finally, a niching method is integrated to preserve the population diversity and prevent premature convergence. In an experimental evaluation we demonstrate the effectiveness of the proposed approach and compare it with other related approaches, using both synthetic and real data

Dynamic gesture recognition using PCA with multi-scale theory and HMM

In this paper, a dynamic gesture recognition system is presented which requires no special hardware other than a Webcam. The system is based on a novel method combining Principal Component Analysis (PCA) with hierarchical multi-scale theory and Discrete Hidden Markov Models (DHMM). We use a hierarchical decision tree based on multiscale theory. Firstly we convolve all members of the training data with a Gaussian kernel, which blurs differences between images and reduces their separation in feature space. This reduces the number of eigenvectors needed to describe the data. A principal component space is computed from the convolved data. We divide the data in this space into two clusters using the k-means algorithm. Then the level of blurring is reduced and PCA is applied to each of the clusters separately. A new principal component space is formed from each cluster. Each of these spaces is then divided into two and the process is repeated. We thus produce a binary tree of principal component spaces where each level of the tree represents a different degree of blurring. The search time is then proportional to the depth of the tree, which makes it possible to search hundreds of gestures in real time. The output of the decision tree is then input into DHMM to recognize temporal information

Neural Network and Bioinformatic Methods for Predicting HIV-1 Protease Inhibitor Resistance

This article presents a new method for predicting viral resistance to seven protease inhibitors from the HIV-1 genotype, and for identifying the positions in the protease gene at which the specific nature of the mutation affects resistance. The neural network Analog ARTMAP predicts protease inhibitor resistance from viral genotypes. A feature selection method detects genetic positions that contribute to resistance both alone and through interactions with other positions. This method has identified positions 35, 37, 62, and 77, where traditional feature selection methods have not detected a contribution to resistance. At several positions in the protease gene, mutations confer differing degress of resistance, depending on the specific amino acid to which the sequence has mutated. To find these positions, an Amino Acid Space is introduced to represent genes in a vector space that captures the functional similarity between amino acid pairs. Feature selection identifies several new positions, including 36, 37, and 43, with amino acid-specific contributions to resistance. Analog ARTMAP networks applied to inputs that represent specific amino acids at these positions perform better than networks that use only mutation locations.Air Force Office of Scientific Research (F49620-01-1-0423); National Geospatial-Intelligence Agency (NMA 201-01-1-2016); National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624