Ecological Kinds and the Units of Conservation

Conservation has often been conducted with the implicit internalization of Aldo Leopold’s claim: “A thing is right when it tends to preserve the integrity, stability and beauty of the biotic community.” This position has been found to be problematic as ecological science has not vindicated the ecological community as an entity which can be stable or coherent. Ecological communities do not form natural kinds, and this has forced ecological scientists to explain ecology in a different manner. Individualist approaches to ecological systems have gained prominence. Individualists claim that ecological systems are better explained at the population level rather than as whole communities. My thesis looks at the implications of the current state of ecological science on conservation biology and emphasizes the importance of biodiversity as assessed at the population level. I defend the position that biodiversity should represent taxonomy and be quantified in reference to phylogenetic structure. This is a defence of biodiversity realism, which conceives of biodiversity as a natural quantity in the world which is measurable, valuable to prudent agents, and causally salient to ecological systems. To address how biodiversity at the population level relates to larger ecological systems I create a methodology designed to identify the relevant ecological system which biodiversity maintains and is maintained by biodiversity. This is done through the context dependent modelling of causal networks indexed to populations. My causal modelling methodology is then utilized to explicate ecological functions. These chapters together provide a framework for conservation science, which can then be applied to novel problems. The final section of the thesis utilises this framework to address whether de-extinction is a worthwhile conservation technique

Group technology: amalgamation with design of organisational structures

Group technology has been studied extensively from an ‘industrial engineering’ perspective (layout, scheduling, workflow, etc.), but less often from an organisational design viewpoint. To study this implication of group technology, the approach of applied systems theory for the design of organisational structures was used as framework for analysis in three empirical cases. To increase the reliability of findings from the analysis of these three empirical cases, five more cases were drawn from archival search. Cluster analysis and product flow analysis were the methods used for forming groups of machines and employees in manufacturing cells, whereas the coding of parts was not employed to this end. Furthermore, the results indicate that the implementation of group technology generally meets shifts in performance requirements caused by competitive pressures, particularly flexibility and responsiveness, albeit the companies considered group technology only when under pressure of ‘poor’ business performance. However, group technology is not always a solution to challenges that companies experience; one empirical case shows that defunctionalisation and scheduling with virtual groups was more beneficial. Nevertheless, when the introduction of group technology is feasible, it also allows firms to consider delegating responsibility for production planning and scheduling to lower levels in the hierarchy and semi-autonomous groups as an alternative to ‘complex’ software applications (a socio-technical approach). Whereas the current study sheds light on the relationship between group technology and design of organisational structures, further research is necessary into the design of these structures and their relationship to group technology

Multi-scale molecular descriptions of human heart failure using single cell, spatial, and bulk transcriptomics

Molecular descriptions of human disease have relied on transcriptomics, the genome-wide measurement of gene expression. In the last years the emergence of capture-based technologies have enabled the transcriptomic profiling of single cells both from dissociated and intact tissues, providing a spatial and cell type specific context that complements the catalog of gene expression changes reported from bulk technologies. In the context of cardiovascular disease, these technologies open the opportunity to study the inter and intra-cellular mechanisms that regulate myocardial remodeling. In this thesis I present comprehensive descriptions of the transcriptional changes in acute and chronic human heart failure using bulk, single cell, and spatial technologies. First, I describe the creation of the Reference of the Heart Failure Transcriptome, a resource built from the meta-analysis of 16 independent studies of human heart failure transcriptomics. Then, I report the first spatial and single cell atlas of human myocardial infarction, and propose a computational strategy to identify compositional, organizational, and molecular tissue differences across distinct time points and physiological zones of damaged myocardium. Finally, I outline a methodology for the multicellular analysis of single cell data that allows for a better understanding of tissue responses and cell type coordination events in cardiovascular disease and that links the knowledge of independent studies at multiple scales. Overall my work demonstrates the importance of the generation of reliable molecular references of disease across scales

Software Engineering Methods for the Internet of Things: A Comparative Review

Accessing different physical objects at any time from anywhere through wireless network heavily impacts the living style of societies worldwide nowadays. Thus, the Internet of Things has now become a hot emerging paradigm in computing environments. Issues like interoperability, software reusability, and platform independence of those physical objects are considered the main current challenges. This raises the need for appropriate software engineering approaches to develop effective and efficient IoT applications software. This paper studies the state of the art of design and development methodologies for IoT software. The aim is to study how proposed approaches have been solved issues of interoperability, reusability, and independence of the platform. A comparative study is presented for the different software engineering methods used for the Internet of Things. Finally, the key research gaps and open issues are highlighted as future directions

New Fundamental Technologies in Data Mining

The progress of data mining technology and large public popularity establish a need for a comprehensive text on the subject. The series of books entitled by "Data Mining" address the need by presenting in-depth description of novel mining algorithms and many useful applications. In addition to understanding each section deeply, the two books present useful hints and strategies to solving problems in the following chapters. The contributing authors have highlighted many future research directions that will foster multi-disciplinary collaborations and hence will lead to significant development in the field of data mining