Equation-free modeling of evolving diseases: Coarse-grained computations with individual-based models

We demonstrate how direct simulation of stochastic, individual-based models can be combined with continuum numerical analysis techniques to study the dynamics of evolving diseases. % Sidestepping the necessity of obtaining explicit population-level models, the approach analyzes the (unavailable in closed form) `coarse' macroscopic equations, estimating the necessary quantities through appropriately initialized, short `bursts' of individual-based dynamic simulation. % We illustrate this approach by analyzing a stochastic and discrete model for the evolution of disease agents caused by point mutations within individual hosts. % Building up from classical SIR and SIRS models, our example uses a one-dimensional lattice for variant space, and assumes a finite number of individuals. % Macroscopic computational tasks enabled through this approach include stationary state computation, coarse projective integration, parametric continuation and stability analysis.Comment: 16 pages, 8 figure

Particle swarm optimization with sequential niche technique for dynamic finite element model updating

Peer reviewedPostprin

Identification of cellular automata based on incomplete observations with bounded time gaps

In this paper, the problem of identifying the cellular automata (CAs) is considered. We frame and solve this problem in the context of incomplete observations, i.e., prerecorded, incomplete configurations of the system at certain, and unknown time stamps. We consider 1-D, deterministic, two-state CAs only. An identification method based on a genetic algorithm with individuals of variable length is proposed. The experimental results show that the proposed method is highly effective. In addition, connections between the dynamical properties of CAs (Lyapunov exponents and behavioral classes) and the performance of the identification algorithm are established and analyzed

The Evolutionary Unfolding of Complexity

We analyze the population dynamics of a broad class of fitness functions that exhibit epochal evolution---a dynamical behavior, commonly observed in both natural and artificial evolutionary processes, in which long periods of stasis in an evolving population are punctuated by sudden bursts of change. Our approach---statistical dynamics---combines methods from both statistical mechanics and dynamical systems theory in a way that offers an alternative to current ``landscape'' models of evolutionary optimization. We describe the population dynamics on the macroscopic level of fitness classes or phenotype subbasins, while averaging out the genotypic variation that is consistent with a macroscopic state. Metastability in epochal evolution occurs solely at the macroscopic level of the fitness distribution. While a balance between selection and mutation maintains a quasistationary distribution of fitness, individuals diffuse randomly through selectively neutral subbasins in genotype space. Sudden innovations occur when, through this diffusion, a genotypic portal is discovered that connects to a new subbasin of higher fitness genotypes. In this way, we identify innovations with the unfolding and stabilization of a new dimension in the macroscopic state space. The architectural view of subbasins and portals in genotype space clarifies how frozen accidents and the resulting phenotypic constraints guide the evolution to higher complexity.Comment: 28 pages, 5 figure

Parameters Identification for a Composite Piezoelectric Actuator Dynamics

This work presents an approach for identifying the model of a composite piezoelectric (PZT) bimorph actuator dynamics, with the objective of creating a robust model that can be used under various operating conditions. This actuator exhibits nonlinear behavior that can be described using backlash and hysteresis. A linear dynamic model with a damping matrix that incorporates the Bouc–Wen hysteresis model and the backlash operators is developed. This work proposes identifying the actuator’s model parameters using the hybrid master-slave genetic algorithm neural network (HGANN). In this algorithm, the neural network exploits the ability of the genetic algorithm to search globally to optimize its structure, weights, biases and transfer functions to perform time series analysis efficiently. A total of nine datasets (cases) representing three different voltage amplitudes excited at three different frequencies are used to train and validate the model. Four cases are considered for training the NN architecture, connection weights, bias weights and learning rules. The remaining five cases are used to validate the model, which produced results that closely match the experimental ones. The analysis shows that damping parameters are inversely proportional to the excitation frequency. This indicates that the suggested hysteresis model is too general for the PZT model in this work. It also suggests that backlash appears only when dynamic forces become dominant