Constraint handling strategies in Genetic Algorithms application to optimal batch plant design

Optimal batch plant design is a recurrent issue in Process Engineering, which can be formulated as a Mixed Integer Non-Linear Programming(MINLP) optimisation problem involving specific constraints, which can be, typically, the respect of a time horizon for the synthesis of various products. Genetic Algorithms constitute a common option for the solution of these problems, but their basic operating mode is not always wellsuited to any kind of constraint treatment: if those cannot be integrated in variable encoding or accounted for through adapted genetic operators, their handling turns to be a thorny issue. The point of this study is thus to test a few constraint handling techniques on a mid-size example in order to determine which one is the best fitted, in the framework of one particular problem formulation. The investigated methods are the elimination of infeasible individuals, the use of a penalty term added in the minimized criterion, the relaxation of the discrete variables upper bounds, dominancebased tournaments and, finally, a multiobjective strategy. The numerical computations, analysed in terms of result quality and of computational time, show the superiority of elimination technique for the former criterion only when the latter one does not become a bottleneck. Besides, when the problem complexity makes the random location of feasible space too difficult, a single tournament technique proves to be the most efficient one

Comparison of Direct Multiobjective Optimization Methods for the Design of Electric Vehicles

"System design oriented methodologies" are discussed in this paper through the comparison of multiobjective optimization methods applied to heterogeneous devices in electrical engineering. Avoiding criteria function derivatives, direct optimization algorithms are used. In particular, deterministic geometric methods such as the Hooke & Jeeves heuristic approach are compared with stochastic evolutionary algorithms (Pareto genetic algorithms). Different issues relative to convergence rapidity and robustness on mixed (continuous/discrete), constrained and multiobjective problems are discussed. A typical electrical engineering heterogeneous and multidisciplinary system is considered as a case study: the motor drive of an electric vehicle. Some results emphasize the capacity of each approach to facilitate system analysis and particularly to display couplings between optimization parameters, constraints, objectives and the driving mission

Set-Based Pre-Processing for Points-To Analysis

We present set-based pre-analysis: a virtually universal op- timization technique for flow-insensitive points-to analysis. Points-to analysis computes a static abstraction of how ob- ject values flow through a program’s variables. Set-based pre-analysis relies on the observation that much of this rea- soning can take place at the set level rather than the value level. Computing constraints at the set level results in sig- nificant optimization opportunities: we can rewrite the in- put program into a simplified form with the same essential points-to properties. This rewrite results in removing both local variables and instructions, thus simplifying the sub- sequent value-based points-to computation. E ectively, set- based pre-analysis puts the program in a normal form opti- mized for points-to analysis. Compared to other techniques for o -line optimization of points-to analyses in the literature, the new elements of our approach are the ability to eliminate statements, and not just variables, as well as its modularity: set-based pre-analysis can be performed on the input just once, e.g., allowing the pre-optimization of libraries that are subsequently reused many times and for di erent analyses. In experiments with Java programs, set-based pre-analysis eliminates 30% of the program’s local variables and 30% or more of computed context-sensitive points-to facts, over a wide set of bench- marks and analyses, resulting in a 20% average speedup (max: 110%, median: 18%)

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems