BIOMedical search engine framework: lightweight and customized implementation of domain-specific biomedical search engines

The Smart Drug Search is publicly accessible at http://sing.ei.uvigo.es/sds/. The BIOMedical Search Engine Framework is freely available for non-commercial use at https://github.com/agjacome/biomsefBackground and Objectives: Text mining and semantic analysis approaches can be applied to the construction of biomedical domain-specific search engines and provide an attractive alternative to create personalized and enhanced search experiences. Therefore, this work introduces the new open-source BIOMedical Search Engine Framework for the fast and lightweight development of domain-specific search engines. The rationale behind this framework is to incorporate core features typically available in search engine frameworks with flexible and extensible technologies to retrieve biomedical documents, annotate meaningful domain concepts, and develop highly customized Web search interfaces. Methods: The BIOMedical Search Engine Framework integrates taggers for major biomedical concepts, such as diseases, drugs, genes, proteins, compounds and organisms, and enables the use of domain-specific controlled vocabulary. Technologies from the Typesafe Reactive Platform, the AngularJS JavaScript framework and the Bootstrap HTML/CSS framework support the customization of the domain-oriented search application. Moreover, the RESTful API of the BIOMedical Search Engine Framework allows the integration of the search engine into existing systems or a complete web interface personalization. Results The construction of the Smart Drug Search is described as proof-of-concept of the BIOMedical Search Engine Framework. This public search engine catalogs scientific literature about antimicrobial resistance, microbial virulence and topics alike. The keyword-based queries of the users are transformed into concepts and search results are presented and ranked accordingly. The semantic graph view portraits all the concepts found in the results and the researcher may look into the relevance of different concepts, the strength of direct relations, and non-trivial, indirect relations. The number of occurrences of the concept shows its importance to the query, and the frequency of concept co-occurrence is indicative of biological relations meaningful to that particular scope of research. Conversely, indirect concept associations, i.e. concepts related by other intermediary concepts, can be useful to integrate information from different studies and look into non-trivial relations. Conclusions The BIOMedical Search Engine Framework supports the development of domain-specific search engines. The key strengths of the framework are modularity and extensibility in terms of software design, the use of open-source consolidated Web technologies, and the ability to integrate any number of biomedical text mining tools and information resources. Currently, the Smart Drug Search keeps over 1,186,000 documents, containing more than 11,854,000 annotations for 77,200 different concepts.This work was partially funded by the [14VI05] ContractProgramme from the University ofVigo and theAgrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa(2012/273).The research leading to these results has also received funding from the European Union Seventh Framework Programme FP7/REGPOT-2012-2013.1 under grant agreement n° 316265,BIOCAPS.This document reflects only the author’s views, and the European Union is not liable for any use that may be made of the information contained herei

Abmash: Mashing Up Legacy Web Applications by Automated Imitation of Human Actions

Many business web-based applications do not offer applications programming interfaces (APIs) to enable other applications to access their data and functions in a programmatic manner. This makes their composition difficult (for instance to synchronize data between two applications). To address this challenge, this paper presents Abmash, an approach to facilitate the integration of such legacy web applications by automatically imitating human interactions with them. By automatically interacting with the graphical user interface (GUI) of web applications, the system supports all forms of integrations including bi-directional interactions and is able to interact with AJAX-based applications. Furthermore, the integration programs are easy to write since they deal with end-user, visual user-interface elements. The integration code is simple enough to be called a "mashup".Comment: Software: Practice and Experience (2013)

Escrow: A large-scale web vulnerability assessment tool

The reliance on Web applications has increased rapidly over the years. At the same time, the quantity and impact of application security vulnerabilities have grown as well. Amongst these vulnerabilities, SQL Injection has been classified as the most common, dangerous and prevalent web application flaw. In this paper, we propose Escrow, a large-scale SQL Injection detection tool with an exploitation module that is light-weight, fast and platform-independent. Escrow uses a custom search implementation together with a static code analysis module to find potential target web applications. Additionally, it provides a simple to use graphical user interface (GUI) to navigate through a vulnerable remote database. Escrow is implementation-agnostic, i.e. It can perform analysis on any web application regardless of the server-side implementation (PHP, ASP, etc.). Using our tool, we discovered that it is indeed possible to identify and exploit at least 100 databases per 100 minutes, without prior knowledge of their underlying implementation. We observed that for each query sent, we can scan and detect dozens of vulnerable web applications in a short space of time, while providing a means for exploitation. Finally, we provide recommendations for developers to defend against SQL injection and emphasise the need for proactive assessment and defensive coding practices

Searching and ranking ontologies on the Semantic Web

The number of ontologies available online is increasing constantly. Tools that are capable of searching, retrieving, and ranking ontologies are becoming crucial to facilitate ontology search and reuse. In this document, we describe OntoSearch, which is a tool for capturing and searching ontologies on the Semantic web. We also briefly describe AKTiveRank which is used to rank OWL ontologies based on certain ontology-structure analysis.

What can be done with the Semantic Web? An overview of Watson-based applications

Thanks to the huge efforts deployed in the community for creating, building and generating semantic information for the Semantic Web, large amounts of machine processable knowledge are now openly available. Watson is an infrastructure component for the Semantic Web, a gateway that provides the necessary functions to support applications in using the Semantic Web. In this paper, we describe a number of applications relying on Watson, with the purpose of demonstrating what can be achieved with the Semantic Web nowadays and what sort of new, smart and useful features can be derived from the exploitation of this large, distributed and heterogeneous base of semantic information