A half century of progress towards a unified neural theory of mind and brain with applications to autonomous adaptive agents and mental disorders

Invited article for the book Artificial Intelligence in the Age of Neural Networks and Brain Computing R. Kozma, C. Alippi, Y. Choe, and F. C. Morabito, Eds. Cambridge, MA: Academic PressThis article surveys some of the main design principles, mechanisms, circuits, and architectures that have been discovered during a half century of systematic research aimed at developing a unified theory that links mind and brain, and shows how psychological functions arise as emergent properties of brain mechanisms. The article describes a theoretical method that has enabled such a theory to be developed in stages by carrying out a kind of conceptual evolution. It also describes revolutionary computational paradigms like Complementary Computing and Laminar Computing that constrain the kind of unified theory that can describe the autonomous adaptive intelligence that emerges from advanced brains. Adaptive Resonance Theory, or ART, is one of the core models that has been discovered in this way. ART proposes how advanced brains learn to attend, recognize, and predict objects and events in a changing world that is filled with unexpected events. ART is not, however, a “theory of everything” if only because, due to Complementary Computing, different matching and learning laws tend to support perception and cognition on the one hand, and spatial representation and action on the other. The article mentions why a theory of this kind may be useful in the design of autonomous adaptive agents in engineering and technology. It also notes how the theory has led to new mechanistic insights about mental disorders such as autism, medial temporal amnesia, Alzheimer’s disease, and schizophrenia, along with mechanistically informed proposals about how their symptoms may be ameliorated

Neuromorphic systems based on memristive devices - From the material science perspective to bio-inspired learning hardware

Hardware computation is facing in the present age a deep transformation of its own paradigms. Silicon based computation is reaching its limit due to the physical constraints of transistor technology. As predicted by the Moore’s law, downscaling of transistor dimensions doubled each year since the 60s, leading nowadays to the extreme of 16-nm channel width of the present state-of-the-art technology. No further improvement is possible, since laws of physics impose a different electrical behavior when lower dimensions are attempted. Multiple solutions are then envisaged, spanning the range from quantum computing to neuromorphic computing. The present dissertation wants to be a preliminary study for understanding the opportunities enabled by neuromorphic computing based on resistive switching memories. In particular, brain inspires technology and architecture of new generation processors because of its unique properties: parallel and distributed computation, superposition of processing and memory unit, low power consumption, to cite only some of them. Such features make brain particularly efficient and robust against degraded data, further than particularly suitable to process and store in memory new nformation. Despite many research projects and some commercial products are already proposing brain-like computing processors, like spiNNaker or IBM’s Bluenorth, they only mimic the brain functioning with standard Silicon technology, that is inherently serial and distinguish between processing and memory unit. Resistive switching technology on the other hand, would allow to overcome many of these issues, enabling a far better match between biological and artificial neuromorphic computation. Resistive switching are, generally speaking, Metal-Insulator-Metal structures able to change their electrical conductance as a consequence of the history of applied electric signal. In such sense, they behave exactly as synapses do in a biological neural networks. For this reason, resistive switching when modeled as memristor, i.e. memory-resistor, can act as artificial synapses and, moreover, are particularly suitable to be interfaced with artificial Silicon neurons that are designed to replicate the biological behavior when excited with electric pulses. Anyhow, from the technological standpoint, there is still no standard on the design and fabrication of resistive switching, so that multiple structure and materials are investigated. In this dissertation, it is reported an analysis of multiple resistive switching devices, based on various materials, i.e. TiO2, ZnO and HfO, and device architectures, i.e. thin film and nanostructured devices, with the scope of both characterizing and comprehending the physics behind resistive switching phenomena. Furthermore, numerical simulations of artificial spiking neural networks, embedding Silicon neurons and HfO-based resistive switching are designed and performed, in order to give a systematic analysis of the performances reached by this new kind of computing paradigm

NEW APPROACHES FOR ESTIMATING HEMISPHERIC LATERALIZATION FROM RESTING STATE FMRI DATA WITH RELATIONSHIP TO AGE, GENDER AND MENTAL DISORDERS

Lateralization is specialization of the brain hemispheres in certain tasks, such as language, mathematics, cognition and motor skills. It is one of the most queried topics related to the human brain. After the invention of modern medical imaging techniques including functional magnetic resonance imaging (fMRI), scientific research about the human brain, including lateralization, gained huge momentum. There have been a remarkable numbers of studies about lateralization and most of these studies focused on investigating which part of the brain dominates in which tasks. However, there have been very few lateralization studies on brain intrinsic activity, i.e., resting state activity where subjects are asked to stay awake while resting without performing any specific tasks. Independent component analysis (ICA), a data-driven blind source separation method, has become one of the conventional data analysis tools for brain imaging data. ICA can separate the brain imaging data into functional regions that are temporally coherent, and functional network connectivity (FNC) of these regions can be computed. FNC is a measure that captures the temporal covariance of the brain networks. In this dissertation, we focus on the lateralization during the resting state and assess hemispheric differences during the resting state. The lateralization of the resting state networks and their association with age and gender is presented using a large resting state fMRI dataset. A novel approach for generating hemisphere specific time-courses and computing FNC inside the hemispheres and between hemispheres is proposed and the relationship of these FNC values with age, gender and mental illness, schizophrenia is reported. Finally, a new framework to estimate power spectral density of 4D brain imaging data and a dimension reduction method to reduce dimensionality from 4D frequency domain to 2D frequency domain has been proposed. This framework helps us to reveal spatiotemporal organization differences between hemispheres. In summary, our work has made several contributions to advance lateralization analysis and has improved our understanding of various aspects of hemispheric differences during the resting stat

BrainPrint: A discriminative characterization of brain morphology

We introduce BrainPrint, a compact and discriminative representation of brain morphology. BrainPrint captures shape information of an ensemble of cortical and subcortical structures by solving the eigenvalue problem of the 2D and 3D Laplace–Beltrami operator on triangular (boundary) and tetrahedral (volumetric) meshes. This discriminative characterization enables new ways to study the similarity between brains; the focus can either be on a specific brain structure of interest or on the overall brain similarity. We highlight four applications for BrainPrint in this article: (i) subject identification, (ii) age and sex prediction, (iii) brain asymmetry analysis, and (iv) potential genetic influences on brain morphology. The properties of BrainPrint require the derivation of new algorithms to account for the heterogeneous mix of brain structures with varying discriminative power. We conduct experiments on three datasets, including over 3000 MRI scans from the ADNI database, 436 MRI scans from the OASIS dataset, and 236 MRI scans from the VETSA twin study. All processing steps for obtaining the compact representation are fully automated, making this processing framework particularly attractive for handling large datasets.National Cancer Institute (U.S.) (1K25-CA181632-01)Athinoula A. Martinos Center for Biomedical Imaging (P41-RR014075)Athinoula A. Martinos Center for Biomedical Imaging (P41-EB015896)National Alliance for Medical Image Computing (U.S.) (U54-EB005149)Neuroimaging Analysis Center (U.S.) (P41-EB015902)National Center for Research Resources (U.S.) (U24 RR021382)National Institute of Biomedical Imaging and Bioengineering (U.S.) (5P41EB015896-15)National Institute of Biomedical Imaging and Bioengineering (U.S.) (R01EB006758)National Institute on Aging (AG022381)National Institute on Aging (5R01AG008122-22)National Institute on Aging (AG018344)National Institute on Aging (AG018386)National Center for Complementary and Alternative Medicine (U.S.) (RC1 AT005728-01)National Institute of Neurological Diseases and Stroke (U.S.) (R01 NS052585-01)National Institute of Neurological Diseases and Stroke (U.S.) (1R21NS072652-01)National Institute of Neurological Diseases and Stroke (U.S.) (1R01NS070963)National Institute of Neurological Diseases and Stroke (U.S.) (R01NS083534)National Institutes of Health (U.S.) ((5U01-MH093765

BrainPrint: A discriminative characterization of brain morphology

We introduce BrainPrint, a compact and discriminative representation of brain morphology. BrainPrint captures shape information of an ensemble of cortical and subcortical structures by solving the eigenvalue problem of the 2D and 3D Laplace–Beltrami operator on triangular (boundary) and tetrahedral (volumetric) meshes. This discriminative characterization enables new ways to study the similarity between brains; the focus can either be on a specific brain structure of interest or on the overall brain similarity. We highlight four applications for BrainPrint in this article: (i) subject identification, (ii) age and sex prediction, (iii) brain asymmetry analysis, and (iv) potential genetic influences on brain morphology. The properties of BrainPrint require the derivation of new algorithms to account for the heterogeneous mix of brain structures with varying discriminative power. We conduct experiments on three datasets, including over 3000 MRI scans from the ADNI database, 436 MRI scans from the OASIS dataset, and 236 MRI scans from the VETSA twin study. All processing steps for obtaining the compact representation are fully automated, making this processing framework particularly attractive for handling large datasets.National Cancer Institute (U.S.) (1K25-CA181632-01)Athinoula A. Martinos Center for Biomedical Imaging (P41-RR014075)Athinoula A. Martinos Center for Biomedical Imaging (P41-EB015896)National Alliance for Medical Image Computing (U.S.) (U54-EB005149)Neuroimaging Analysis Center (U.S.) (P41-EB015902)National Center for Research Resources (U.S.) (U24 RR021382)National Institute of Biomedical Imaging and Bioengineering (U.S.) (5P41EB015896-15)National Institute of Biomedical Imaging and Bioengineering (U.S.) (R01EB006758)National Institute on Aging (AG022381)National Institute on Aging (5R01AG008122-22)National Institute on Aging (AG018344)National Institute on Aging (AG018386)National Center for Complementary and Alternative Medicine (U.S.) (RC1 AT005728-01)National Institute of Neurological Diseases and Stroke (U.S.) (R01 NS052585-01)National Institute of Neurological Diseases and Stroke (U.S.) (1R21NS072652-01)National Institute of Neurological Diseases and Stroke (U.S.) (1R01NS070963)National Institute of Neurological Diseases and Stroke (U.S.) (R01NS083534)National Institutes of Health (U.S.) ((5U01-MH093765

Display Enhanced Testing For Concussions And Mild Traumatic Brain Injury

Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive functions of an individual including information processing speed, working memory, work list learning and recall, along with variations of these tasks. Immersive and non-immersive systems and methods are disclosed. Testing and results feedback using the present invention may be completed in real time, typically in less than 15 minutes.Emory UniversityGeorgia Tech Research Corporatio

Experimental Design Modulates Variance in BOLD Activation: The Variance Design General Linear Model

Typical fMRI studies have focused on either the mean trend in the blood-oxygen-level-dependent (BOLD) time course or functional connectivity (FC). However, other statistics of the neuroimaging data may contain important information. Despite studies showing links between the variance in the BOLD time series (BV) and age and cognitive performance, a formal framework for testing these effects has not yet been developed. We introduce the Variance Design General Linear Model (VDGLM), a novel framework that facilitates the detection of variance effects. We designed the framework for general use in any fMRI study by modeling both mean and variance in BOLD activation as a function of experimental design. The flexibility of this approach allows the VDGLM to i) simultaneously make inferences about a mean or variance effect while controlling for the other and ii) test for variance effects that could be associated with multiple conditions and/or noise regressors. We demonstrate the use of the VDGLM in a working memory application and show that engagement in a working memory task is associated with whole-brain decreases in BOLD variance.Comment: 18 pages, 7 figure