Motion Artifact Processing Techniques for Physiological Signals

The combination of reducing birth rate and increasing life expectancy continues to drive the demographic shift toward an ageing population and this is placing an ever-increasing burden on our healthcare systems. The urgent need to address this so called healthcare \time bomb" has led to a rapid growth in research into ubiquitous, pervasive and distributed healthcare technologies where recent advances in signal acquisition, data storage and communication are helping such systems become a reality. However, similar to recordings performed in the hospital environment, artifacts continue to be a major issue for these systems. The magnitude and frequency of artifacts can vary signicantly depending on the recording environment with one of the major contributions due to the motion of the subject or the recording transducer. As such, this thesis addresses the challenges of the removal of this motion artifact removal from various physiological signals. The preliminary investigations focus on artifact identication and the tagging of physiological signals streams with measures of signal quality. A new method for quantifying signal quality is developed based on the use of inexpensive accelerometers which facilitates the appropriate use of artifact processing methods as needed. These artifact processing methods are thoroughly examined as part of a comprehensive review of the most commonly applicable methods. This review forms the basis for the comparative studies subsequently presented. Then, a simple but novel experimental methodology for the comparison of artifact processing techniques is proposed, designed and tested for algorithm evaluation. The method is demonstrated to be highly eective for the type of artifact challenges common in a connected health setting, particularly those concerned with brain activity monitoring. This research primarily focuses on applying the techniques to functional near infrared spectroscopy (fNIRS) and electroencephalography (EEG) data due to their high susceptibility to contamination by subject motion related artifact. Using the novel experimental methodology, complemented with simulated data, a comprehensive comparison of a range of artifact processing methods is conducted, allowing the identication of the set of the best performing methods. A novel artifact removal technique is also developed, namely ensemble empirical mode decomposition with canonical correlation analysis (EEMD-CCA), which provides the best results when applied on fNIRS data under particular conditions. Four of the best performing techniques were then tested on real ambulatory EEG data contaminated with movement artifacts comparable to those observed during in-home monitoring. It was determined that when analysing EEG data, the Wiener lter is consistently the best performing artifact removal technique. However, when employing the fNIRS data, the best technique depends on a number of factors including: 1) the availability of a reference signal and 2) whether or not the form of the artifact is known. It is envisaged that the use of physiological signal monitoring for patient healthcare will grow signicantly over the next number of decades and it is hoped that this thesis will aid in the progression and development of artifact removal techniques capable of supporting this growth

Artifact reduction in multichannel pervasive EEG using hybrid WPT-ICA and WPT-EMD signal decomposition techniques

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this record.In order to reduce the muscle artifacts in multi-channel pervasive Electroencephalogram (EEG) signals, we here propose and compare two hybrid algorithms by combining the concept of wavelet packet transform (WPT), empirical mode decomposition (EMD) and Independent Component Analysis (ICA). The signal cleaning performances of WPT-EMD and WPT-ICA algorithms have been compared using a signal-to-noise ratio (SNR)-like criterion for artifacts. The algorithms have been tested on multiple trials of four different artifact cases viz. eye-blinking and muscle artifacts including left and right hand movement and head-shaking.This work was supported by FP7 EU funded MICHELANGELO project, Grant Agreement #288241

Detection of Human Vigilance State During Locomotion Using Wearable FNIRS

Human vigilance is a cognitive function that requires sustained attention toward change in the environment. Human vigilance detection is a widely investigated topic which can be accomplished by various approaches. Most studies have focused on stationary vigilance detection due to the high effect of interference such as motion artifacts which are prominent in common movements such as walking. Functional Near-Infrared Spectroscopy is a preferred modality in vigilance detection due to the safe nature, the low cost and ease of implementation. fNIRS is not immune to motion artifact interference, and therefore human vigilance detection performance would be severely degraded when studied during locomotion. Properly treating and removing walking-induced motion artifacts from the contaminated signals is crucial to ensure accurate vigilance detection. This study compared the vigilance level detection during both stationary and walking states and confirmed that the performance of vigilance level detection during walking is significantly deteriorated (with a

Motion Artifacts Correction from Single-Channel EEG and fNIRS Signals using Novel Wavelet Packet Decomposition in Combination with Canonical Correlation Analysis

The electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) signals, highly non-stationary in nature, greatly suffers from motion artifacts while recorded using wearable sensors. This paper proposes two robust methods: i) Wavelet packet decomposition (WPD), and ii) WPD in combination with canonical correlation analysis (WPD-CCA), for motion artifact correction from single-channel EEG and fNIRS signals. The efficacy of these proposed techniques is tested using a benchmark dataset and the performance of the proposed methods is measured using two well-established performance matrices: i) Difference in the signal to noise ratio ({\Delta}SNR) and ii) Percentage reduction in motion artifacts ({\eta}). The proposed WPD-based single-stage motion artifacts correction technique produces the highest average {\Delta}SNR (29.44 dB) when db2 wavelet packet is incorporated whereas the greatest average {\eta} (53.48%) is obtained using db1 wavelet packet for all the available 23 EEG recordings. Our proposed two-stage motion artifacts correction technique i.e. the WPD-CCA method utilizing db1 wavelet packet has shown the best denoising performance producing an average {\Delta}SNR and {\eta} values of 30.76 dB and 59.51%, respectively for all the EEG recordings. On the other hand, the two-stage motion artifacts removal technique i.e. WPD-CCA has produced the best average {\Delta}SNR (16.55 dB, utilizing db1 wavelet packet) and largest average {\eta} (41.40%, using fk8 wavelet packet). The highest average {\Delta}SNR and {\eta} using single-stage artifacts removal techniques (WPD) are found as 16.11 dB and 26.40%, respectively for all the fNIRS signals using fk4 wavelet packet. In both EEG and fNIRS modalities, the percentage reduction in motion artifacts increases by 11.28% and 56.82%, respectively when two-stage WPD-CCA techniques are employed.Comment: 25 pages, 10 figures and 2 table

Advancing functional connectivity research from association to causation

Cognition and behavior emerge from brain network interactions, such that investigating causal interactions should be central to the study of brain function. Approaches that characterize statistical associations among neural time series-functional connectivity (FC) methods-are likely a good starting point for estimating brain network interactions. Yet only a subset of FC methods ('effective connectivity') is explicitly designed to infer causal interactions from statistical associations. Here we incorporate best practices from diverse areas of FC research to illustrate how FC methods can be refined to improve inferences about neural mechanisms, with properties of causal neural interactions as a common ontology to facilitate cumulative progress across FC approaches. We further demonstrate how the most common FC measures (correlation and coherence) reduce the set of likely causal models, facilitating causal inferences despite major limitations. Alternative FC measures are suggested to immediately start improving causal inferences beyond these common FC measures

Assessing the performance of ultrafast vector flow imaging in the neonatal heart via multiphysics modeling and In vitro experiments

Ultrafast vector flow imaging would benefit newborn patients with congenital heart disorders, but still requires thorough validation before translation to clinical practice. This paper investigates 2-D speckle tracking (ST) of intraventricular blood flow in neonates when transmitting diverging waves at ultrafast frame rate. Computational and in vitro studies enabled us to quantify the performance and identify artifacts related to the flow and the imaging sequence. First, synthetic ultrasound images of a neonate's left ventricular flow pattern were obtained with the ultrasound simulator Field II by propagating point scatterers according to 3-D intraventricular flow fields obtained with computational fluid dynamics (CFD). Noncompounded diverging waves (opening angle of 60 degrees) were transmitted at a pulse repetition frequency of 9 kHz. ST of the B-mode data provided 2-D flow estimates at 180 Hz, which were compared with the CFD flow field. We demonstrated that the diastolic inflow jet showed a strong bias in the lateral velocity estimates at the edges of the jet, as confirmed by additional in vitro tests on a jet flow phantom. Furthermore, ST performance was highly dependent on the cardiac phase with low flows (< 5 cm/s), high spatial flow gradients, and out-of-plane flow as deteriorating factors. Despite the observed artifacts, a good overall performance of 2-D ST was obtained with a median magnitude underestimation and angular deviation of, respectively, 28% and 13.5 degrees during systole and 16% and 10.5 degrees during diastole

AUTOMATED ARTIFACT REMOVAL AND DETECTION OF MILD COGNITIVE IMPAIRMENT FROM SINGLE CHANNEL ELECTROENCEPHALOGRAPHY SIGNALS FOR REAL-TIME IMPLEMENTATIONS ON WEARABLES

Electroencephalogram (EEG) is a technique for recording asynchronous activation of neuronal firing inside the brain with non-invasive scalp electrodes. EEG signal is well studied to evaluate the cognitive state, detect brain diseases such as epilepsy, dementia, coma, autism spectral disorder (ASD), etc. In this dissertation, the EEG signal is studied for the early detection of the Mild Cognitive Impairment (MCI). MCI is the preliminary stage of Dementia that may ultimately lead to Alzheimers disease (AD) in the elderly people. Our goal is to develop a minimalistic MCI detection system that could be integrated to the wearable sensors. This contribution has three major aspects: 1) cleaning the EEG signal, 2) detecting MCI, and 3) predicting the severity of the MCI using the data obtained from a single-channel EEG electrode. Artifacts such as eye blink activities can corrupt the EEG signals. We investigate unsupervised and effective removal of ocular artifact (OA) from single-channel streaming raw EEG data. Wavelet transform (WT) decomposition technique was systematically evaluated for effectiveness of OA removal for a single-channel EEG system. Discrete Wavelet Transform (DWT) and Stationary Wavelet Transform (SWT), is studied with four WT basis functions: haar, coif3, sym3, and bior4.4. The performance of the artifact removal algorithm was evaluated by the correlation coefficients (CC), mutual information (MI), signal to artifact ratio (SAR), normalized mean square error (NMSE), and time-frequency analysis. It is demonstrated that WT can be an effective tool for unsupervised OA removal from single channel EEG data for real-time applications.For the MCI detection from the clean EEG data, we collected the scalp EEG data, while the subjects were stimulated with five auditory speech signals. We extracted 590 features from the Event-Related Potential (ERP) of the collected EEG signals, which included time and spectral domain characteristics of the response. The top 25 features, ranked by the random forest method, were used for classification models to identify subjects with MCI. Robustness of our model was tested using leave-one-out cross-validation while training the classifiers. Best results (leave-one-out cross-validation accuracy 87.9%, sensitivity 84.8%, specificity 95%, and F score 85%) were obtained using support vector machine (SVM) method with Radial Basis Kernel (RBF) (sigma = 10, cost = 102). Similar performances were also observed with logistic regression (LR), further validating the results. Our results suggest that single-channel EEG could provide a robust biomarker for early detection of MCI. We also developed a single channel Electro-encephalography (EEG) based MCI severity monitoring algorithm by generating the Montreal Cognitive Assessment (MoCA) scores from the features extracted from EEG. We performed multi-trial and single-trail analysis for the algorithm development of the MCI severity monitoring. We studied Multivariate Regression (MR), Ensemble Regression (ER), Support Vector Regression (SVR), and Ridge Regression (RR) for multi-trial and deep neural regression for the single-trial analysis. In the case of multi-trial, the best result was obtained from the ER. In our single-trial analysis, we constructed the time-frequency image from each trial and feed it to the convolutional deep neural network (CNN). Performance of the regression models was evaluated by the RMSE and the residual analysis. We obtained the best accuracy with the deep neural regression method

Guest Editorial Cardiovascular Health Informatics: Risk Screening and Intervention

Despite enormous efforts to prevent cardiovascular disease (CVD) in the past, it remains the leading cause of death in most countries worldwide. Around two-thirds of these deaths are due to acute events, which frequently occur suddenly and are often fatal beforemedical care can be given. New strategies for screening and early intervening CVD, in addition to the conventional methods, are therefore needed in order to provide personalized and pervasive healthcare. In this special issue, selected emerging technologies in health informatics for screening and intervening CVDs are reported. These papers include reviews or original contributions on 1) new potential genetic biomarkers for screening CVD outcomes and high-throughput techniques for mining genomic data; 2) new imaging techniques for obtaining faster and higher resolution images of cardiovascular imaging biomarkers such as the cardiac chambers and atherosclerotic plaques in coronary arteries, as well as possible automatic segmentation, identification, or fusion algorithms; 3) new physiological biomarkers and novel wearable and home healthcare technologies for monitoring them in daily lives; 4) new personalized prediction models of plaque formation and progression or CVD outcomes; and 5) quantifiable indices and wearable systems to measure them for early intervention of CVD through lifestyle changes. It is hoped that the proposed technologies and systems covered in this special issue can result in improved CVD management and treatment at the point of need, offering a better quality of life to the patient

Study and analysis of motion artifacts for ambulatory electroencephalography

Motion artifacts contribute complexity in acquiring clean electroencephalography (EEG) data. It is one of the major challenges for ambulatory EEG. The performance of mobile health monitoring, neurological disorders diagnosis and surgeries can be significantly improved by reducing the motion artifacts. Although different papers have proposed various novel approaches for removing motion artifacts, the datasets used to validate those algorithms are questionable. In this paper, a unique EEG dataset was presented where ten different activities were performed. No such previous EEG recordings using EMOTIV EEG headset are available in research history that explicitly mentioned and considered a number of daily activities that induced motion artifacts in EEG recordings. Quantitative study shows that in comparison to correlation coefficient, the coherence analysis depicted a better similarity measure between motion artifacts and motion sensor data. Motion artifacts were characterized with very low frequency which overlapped with the Delta rhythm of the EEG. Also, a general wavelet transform based approach was presented to remove motion artifacts. Further experiment and analysis with more similarity metrics and longer recording duration for each activity is required to finalize the characteristics of motion artifacts and henceforth reliably identify and subsequently remove the motion artifacts in the contaminated EEG recordings