A FPGA/DSP based ultrasound system for tumor detection

This work presents a method of detection of size and location of tumor using ultrasound transmission. The system utilizes Quantitative Ultrasound (QUS) which means sending an ultrasound signal from a transmitter and receiving it at multiple receivers. This received signal is analyzed for echogenic as well as echolucent tumors to differentiate between the two along with non-tumorous sample and also for delay, signal distortion to determine the size/location of the tumor. This analysis is further implemented using Field Programmable Gate Array (FPGA) and Digital Signal Processor (DSP) technologies. The proposed detection system utilizes Low Transient Pulse (LTP) technique. In this co-design architecture, the DSP carries out analysis of received demodulated signal at a lower speed while the FPGA runs at 62.5MHz for the generation of LTP signal and to demodulate bandpass ultrasonic signal sampled at 1MHz which interrupts DSP at every 1µS. This work elaborates the implementation of Quadrature Amplitude Modulation (QAM) receiver on FPGA for received signal from ultrasound detector. LTP is applied to the tumor samples through the transmitter and the received signal at ultrasonic receiver is passed through QAM to get different maxima (peaks) which are then further used for calculation of the location and subsequently, the size of the tumor using DSP. This dual platform co-design demonstrates application of a FPGA/DSP platform for the generation of low transient pulse as well as processing of the received signal

Wall shear stress measurement in carotid artery phantoms with variation in degree of stenosis using plane wave vector doppler

Wall shear stress (WSS) plays an important role in the formation, growth, and rupture of atherosclerotic plaques in arteries. This study measured WSS in diseased carotid artery phantoms with degrees of stenosis varying from 0 to 60% with both steady and pulsatile flow. Experiments were performed using in silico and real flow phantoms. Blood velocities were estimated using plane wave (PW) vector Doppler. Wall shear stress was then estimated from the velocity gradient near the wall multiplied by the viscosity of a blood-mimicking fluid. The estimated WSS using the in silico phantom agreed within 10% of the ground-truth values (root-mean-square error). The phantom experiment showed that the mean WSS and maximum WSS increased with the increasing degree of stenosis. The simulation and experiment results provide the necessary validation data to give confidence in WSS measurements in patients using the PW vector Doppler technique

Design, analysis and evaluation of sigma-delta based beamformers for medical ultrasound imaging applications

The inherent analogue nature of medical ultrasound signals in conjunction with the abundant merits provided by digital image acquisition, together with the increasing use of relatively simple front-end circuitries, have created considerable demand for single-bit beamformers in digital ultrasound imaging systems. Furthermore, the increasing need to design lightweight ultrasound systems with low power consumption and low noise, provide ample justification for development and innovation in the use of single-bit beamformers in ultrasound imaging systems. The overall aim of this research program is to investigate, establish, develop and confirm through a combination of theoretical analysis and detailed simulations, that utilize raw phantom data sets, suitable techniques for the design of simple-to-implement hardware efficient digital ultrasound beamformers to address the requirements for 3D scanners with large channel counts, as well as portable and lightweight ultrasound scanners for point-of-care applications and intravascular imaging systems. In addition, the stability boundaries of higher-order High-Pass (HP) and Band-Pass (BP) Σ−Δ modulators for single- and dual- sinusoidal inputs are determined using quasi-linear modeling together with the describing-function method, to more accurately model the modulator quantizer. The theoretical results are shown to be in good agreement with the simulation results for a variety of input amplitudes, bandwidths, and modulator orders. The proposed mathematical models of the quantizer will immensely help speed up the design of higher order HP and BP Σ−Δ modulators to be applicable for digital ultrasound beamformers. Finally, a user friendly design and performance evaluation tool for LP, BP and HP modulators is developed. This toolbox, which uses various design methodologies and covers an assortment of modulators topologies, is intended to accelerate the design process and evaluation of modulators. This design tool is further developed to enable the design, analysis and evaluation of beamformer structures including the noise analyses of the final B-scan images. Thus, this tool will allow researchers and practitioners to design and verify different reconstruction filters and analyze the results directly on the B-scan ultrasound images thereby saving considerable time and effort

Real-time digital signal processing system for normal probe diffraction technique

Ultrasonic systems are widely used in many fields of non-destructive testing. The increasing requirement for high quality steel product stirs the improvement of both ultrasonic instruments and testing methods. The thesis indicates the basics of ultrasonic testing and Digital Signal Processing (DSP) technology for the development of an ultrasonic system. The aim of this project was to apply a new ultrasonic testing method - the Normal Probe Diffraction method to course grained steel in real-time and investigate whether the potential of probability of detection (POD) has been improved. The theories and corresponding experiment set-up of pulse-echo method, TOFD and NPD method are explained and demonstrated separately. A comparison of these methods shows different contributions made by these methods using different types of algorithms and signals. Non-real-time experiments were carried out on a VI calibration block using an USPC 3100 ultrasonic testing card to implement pulse-echo and NPD method respectively. The experiments and algorithm were simulated and demonstrated in Matlab. A low frequency Single-transmitter-multi-receiver ultrasonic system was designed and built with a digital development board and an analogue daughter card to transmit or receive signals asynchronously. A high frequency high voltage amplifier was designed to drive the ultrasonic probes. A Matlab simulation system built with Simulink indicates that the Signal to Noise Ratio (SNR) can be improved with an increment of up to 3dB theoretically based on the simulation results using DSP techniques. The DSP system hardware and software was investigated and a real-time DSP hardware system was supposed to be built to implement the high frequency system using a rapid code generated system based on Matlab Simulink model and the method was presented. However, extra effort needs to be taken to program the hardware using a low-level computer language to make the system work stably and efficiently

Blood Velocities Estimation using Ultrasound

This thesis consists of two parts. In the rst part, the iterative data-adaptive BIAA spectral estimation technique was extended to estimate lateral blood velocities using ultrasound scanners. The BIAA method makes no assumption on samples depth or sampling pattern, and therefore allows for transmission in duplex mode imaging. The technique was examined on a realistic Field II simulation data set, and showed fewer spectral artifacts in comparison with other techniques. In the second part of the thesis, another common problem in blood velocity estimation has been investigated, namely strong backscattered signals from stationary echoes. Two methods have been tested to examine the possibility of overcoming this problem. However, neither of these methods resulted in a better estimation of the blood velocities, most likely as the clutter characteristics in color ow images vary too rapidly to allow for this form of models. This might be a result of the non-stationary tissue motions which could be caused by a variety of factors, such as cardiac activities, respiration, transducer/patient movement, or a combination of them

Real-time quantitative sonoelastography in an ultrasound research system

Quantitative Sono-Elastographie ist eine neue Technologie für die Ultraschall Bildgebung, die Radiologen maligne Tumoren ohne Risiko der strahlungsinduzierten Krebs (d.h. Mammographie) zu erfassen können. Aufgrund gefunden Rechenkomplexität in der aktuellen Algorithmen, Implementierung von Echtzeit-Anwendungen, die Prüfungsverfahren profitieren wurde jedoch noch nicht berichtet. Zusätzlich, aktuelle Schätzer für die Darstellung eine Elastizität Bilder vorhanden Artefakte der hohen Schätzung Varianz, die die Techniker in die Gegenwart steifer Massen irreführen könnten und zwar, falsch-positive Diagnose zu erzeugen. In dieser Arbeit wird eine GPU-basierte Elastographie-System entwickelt und an einem Forschungsultraschallgeräten implementiert. Quantitative Elastizität in Echtzeit bei 2 FPS mit einer Verbesserung Rechenzeitfaktor aus 26 wird gezeigt. Validierung der Systemgenauigkeit Anzeige wurde, auf Gelatinebasis Gewebe Phantome durchgeführt., waren niedrige Vorspannung der Elastizitätswerte berichtet wurde (4,7 %) bei geringe Anregungsfrequenzen nachahmt. Ausserdem wird eine neue Elastizität Schätzer auf quantitative Sono-Elastographie basiert eingeführt. Ein lineares Problem wurde entlang der seitlichen Abmessung modelliert und eine Regularisierung Methode wurde implementieren. Elastizität Bilder mit niedriger Vorspannung wurde darstellen (1,48 %) sowie seine Leistung in einer Brust kalibrierte Phantom mit verbesserter CNR (47,3 dB) im Vergleich mit anderen Schätzer ausgewertet sowie die Verringerung Seiten Artefakte bereits erwähnt in der Literatur (PD: 22,7 dB, 1DH 28,7 dB) gefunden. Diese zwei Beitrag profitieren, die Umsetzung und Entwicklung weiterer Elastographie Techniken, die eine verbesserte Qualität der Elastizität Bilder liefern könnten und somit eine verbesserte Genauigkeit der Diagnose.Quantitative sonoelastography is an alternative technology for ultrasound imaging that helps radiologist to diagnose malignant tumors with no risk of radiation-induced cancer (i.e. mammography). However, due to the high computational complexity found in the current algorithms, implementation of real-time systems that could benefit examination procedures has not been yet reported. Additionally, elasticity maps depicted from current estimators feature artifacts of high estimation variance that could mislead the technician into the presence of stiffer masses, generating false positive diagnosis. In this thesis, a GPU-based elastography system was designed and implemented on a research ultrasound equipment, displaying quantitative elasticity in real-time at 2 FPS with an improvement computational time factor of 26. Validation of the system accuracy was conducted on gelatin-based tissue mimicking phantoms, where low bias of elasticity values were reported (4.7%) at low excitation frequencies. Additionally, a new elasticity estimator based on quantitative sonoelastography was developed. A linear problem was modeled from the acquired sonolastography data along the lateral dimension and a regularization method was implemented. The resulting elasticity images presented low bias (1.48%), enhanced CNR and reduced lateral artifacts when evaluating the algorithm’s performance in a breast calibrated phantom and comparing it with other estimators found in the literature. These two contribution benefit the implementation and development of further elastography techniques that could provide enhanced quality of elasticity images and thus, improved accuracy of diagnosis.Tesi

The Acoustic Hologram and Particle Manipulation with Structured Acoustic Fields

This book shows how arbitrary acoustic wavefronts can be encoded in the thickness profile of a phase plate - the acoustic hologram. The workflow for design and implementation of these elements has been developed and is presented in this work along with examples in microparticle assembly, object propulsion and levitation in air. To complement these results, a fast thermographic measurement technique has been developed to scan and validate 3D ultrasound fields in a matter of seconds