3D vasculature segmentation using localized hybrid level-set method

Background: Intensity inhomogeneity occurs in many medical images, especially in vessel images. Overcoming the difficulty due to image inhomogeneity is crucial for the segmentation of vessel image. Methods: This paper proposes a localized hybrid level-set method for the segmentation of 3D vessel image. The proposed method integrates both local region information and boundary information for vessel segmentation, which is essential for the accurate extraction of tiny vessel structures. The local intensity information is firstly embedded into a region-based contour model, and then incorporated into the level-set formulation of the geodesic active contour model. Compared with the preset global threshold based method, the use of automatically calculated local thresholds enables the extraction of the local image information, which is essential for the segmentation of vessel images. Results: Experiments carried out on the segmentation of 3D vessel images demonstrate the strengths of using locally specified dynamic thresholds in our level-set method. Furthermore, both qualitative comparison and quantitative validations have been performed to evaluate the effectiveness of our proposed model. Conclusions: Experimental results and validations demonstrate that our proposed model can achieve more promising segmentation results than the original hybrid method does

Segmentation of Intensity-Corrupted Medical Images Using Adaptive Weight-Based Hybrid Active Contours

6Segmentation accuracy is an important criterion for evaluating the performance of segmentation techniques used to extract objects of interest from images, such as the active contour model. However, segmentation accuracy can be affected by image artifacts such as intensity inhomogeneity, which makes it difficult to extract objects with inhomogeneous intensities. To address this issue, this paper proposes a hybrid region-based active contour model for the segmentation of inhomogeneous images. The proposed hybrid energy functional combines local and global intensity functions; an incorporated weight function is parameterized based on local image contrast. The inclusion of this weight function smoothens the contours at different intensity level boundaries, thereby yielding improved segmentation. The weight function suppresses false contour evolution and also regularizes object boundaries. Compared with other state-of-the-art methods, the proposed approach achieves superior results over synthetic and real images. Based on a quantitative analysis over the mini-MIAS and PH2 databases, the superiority of the proposed model in terms of segmentation accuracy, as compared with the ground truths, was confirmed. Furthermore, when using the proposed model, the processing time for image segmentation is lower than those when using other methods.openopenMemon A.A.; Soomro S.; Shahid M.T.; Munir A.; Niaz A.; Choi K.N.Memon, A. A.; Soomro, S.; Shahid, M. T.; Munir, A.; Niaz, A.; Choi, K. N

2D-Sigmoid Enhancement Prior to Segment MRI Glioma Tumour

Tumour identification has always been a topic that interested researchers around the world. The most challenging phase in tumour identification based on brain MR image is the segmentation of the tumour contour which may contain many unwanted details. Intensity inhomogeneities often occur in real world images and may cause the difficulties in image segmentation. In  order to overcome the difficulties caused by intensity  inhomogeneity,  the  study presented  pre-processing prior to a region based active contour model with modification of Region Scalable Fitting (MRF) method for image segmentation. Region based active contour model that draw upon intensity information in  local regions.  The  pre-processing  is  a  kind  of image  enhancement which applies  the  2D-sigmoid function at tumour boundary.  2D-sigmoid function enhances the contrast in the brain MRI image for pre-processing steps.   Enhanced pixel value, F(x, y), is the ‘S’ shape function of intensity I (x, y) of the image at the point (x, y), width of the gradient magnitude around brain image (α) and gradient magnitude around brain image (β). Experimental results show desirable of MRF method in terms of computation efficiency

New Region-Scalable Discriminant and Fitting Energy Functional for Driving Geometric Active Contours in Medical Image Segmentation

We propose a novel region-based geometric active contour model that uses region-scalable discriminant and fitting energy functional for handling the intensity inhomogeneity and weak boundary problems in medical image segmentation. The region-scalable discriminant and fitting energy functional is defined to capture the image intensity characteristics in local and global regions for driving the evolution of active contour. The discriminant term in the model aims at separating background and foreground in scalable regions while the fitting term tends to fit the intensity in these regions. This model is then transformed into a variational level set formulation with a level set regularization term for accurate computation. The new model utilizes intensity information in the local and global regions as much as possible; so it not only handles better intensity inhomogeneity, but also allows more robustness to noise and more flexible initialization in comparison to the original global region and regional-scalable based models. Experimental results for synthetic and real medical image segmentation show the advantages of the proposed method in terms of accuracy and robustness

Segmentation of Intensity Inhomogeneous Brain MR Images Using Active Contours

Segmentation of intensity inhomogeneous regions is a well-known problem in image analysis applications. This paper presents a region-based active contour method for image segmentation, which properly works in the context of intensity inhomogeneity problem. The proposed region-based active contour method embeds both region and gradient information unlike traditional methods. It contains mainly two terms, area and length, in which the area term practices a new region-based signed pressure force (SPF) function, which utilizes mean values from a certain neighborhood using the local binary fitted (LBF) energy model. In turn, the length term uses gradient information. The novelty of our method is to locally compute new SPF function, which uses local mean values and is able to detect boundaries of the homogenous regions. Finally, a truncated Gaussian kernel is used to regularize the level set function, which not only regularizes it but also removes the need of computationally expensive reinitialization. The proposed method targets the segmentation problem of intensity inhomogeneous images and reduces the time complexity among locally computed active contour methods. The experimental results show that the proposed method yields better segmentation result as well as less time complexity compared with the state-of-the-art active contour methods

Hybrid SPF and KD Operator-Based Active Contour Model for Image Segmentation

Image segmentation is a crucial stage of image analysis systems because it detects and extracts regions of interest for further processing, such as image recognition and the image description. However, segmenting images is not always easy because segmentation accuracy depends significantly on image characteristics, such as color, texture, and intensity. Image inhomogeneity profoundly degrades the segmentation performance of segmentation models. This article contributes to image segmentation literature by presenting a hybrid Active Contour Model (ACM) based on a Signed Pressure Force (SPF) function parameterized with a Kernel Difference (KD) operator. An SPF function includes information from both the local and global regions, making the proposed model independent of the initial contour position. The proposed model uses an optimal KD operator parameterized with weight coefficients to capture weak and blurred boundaries of inhomogeneous objects in images. Combined global and local image statistics were computed and added to the proposed energy function to increase the proposed model's sensitivity. The segmentation time complexity of the proposed model was calculated and compared with previous state-of-the-art active contour methods. The results demonstrated the significant superiority of the proposed model over other methods. Furthermore, a quantitative analysis was performed using the mini-MIAS database. Despite the presence of complex inhomogeneity, the proposed model demonstrated the highest segmentation accuracy when compared to other methods

A hybrid active contour segmentation method for myocardial D-SPECT images

Ischaemic heart disease has become one of the leading causes of mortality worldwide. Dynamic single-photon emission computed tomography (D-SPECT) is an advanced routine diagnostic tool commonly used to validate myocardial function in patients suffering from various heart diseases. Accurate automatic localization and segmentation of myocardial regions is helpful in creating a three-dimensional myocardial model and assisting clinicians to perform assessments of myocardial function. Thus, image segmentation is a key technology in preclinical cardiac studies. Intensity inhomogeneity is one of the common challenges in image segmentation and is caused by image artefacts and instrument inaccuracy. In this paper, a novel region-based active contour model that can segment the myocardial D-SPECT image accurately is presented. First, a local region-based fitting image is defined based on information related to the intensity. Second, a likelihood fitting image energy function is built in a local region around each point in a given vector-valued image. Next, the level set method is used to present a global energy function with respect to the neighbourhood centre. The proposed approach guarantees precision and computational efficiency by combining the region-scalable fitting energy (RSF) model and local image fitting energy (LIF) model, and it can solve the issue of high sensitivity to initialization for myocardial D-SPECT segmentation

Partitioning intensity inhomogeneity colour images via Saliency-based active contour

Partitioning or segmenting intensity inhomogeneity colour images is a challenging problem in computer vision and image shape analysis. Given an input image, the active contour model (ACM) which is formulated in variational framework is regularly used to partition objects in the image. A selective type of variational ACM approach is better than a global approach for segmenting specific target objects, which is useful for applications such as tumor segmentation or tissue classification in medical imaging. However, the existing selective ACMs yield unsatisfactory outcomes when performing the segmentation for colour (vector-valued) with intensity variations. Therefore, our new approach incorporates both local image fitting and saliency maps into a new variational selective ACM to tackle the problem. The euler-lagrange (EL) equations were presented to solve the proposed model. Thirty combinations of synthetic and medical images were tested. The visual observation and quantitative results show that the proposed model outshines the other existing models by average, with the accuracy of 2.23% more than the compared model and the Dice and Jaccard coefficients which were around 12.78% and 19.53% higher, respectively, than the compared model

Hybrid Active Contour Based on Local and Global Statistics Parameterized by Weight Coefficients for Inhomogeneous Image Segmentation

Image inhomogeneity often occurs in real-world images and may present considerable difficulties during image segmentation. Therefore, this paper presents a new approach for the segmentation of inhomogeneous images. The proposed hybrid active contour model is formulated by combining the statistical information of both the local and global region-based energy fitting models. The inclusion of the local region-based energy fitting model assists in extracting the inhomogeneous intensity regions, whereas the curve evolution over the homogeneous regions is accelerated by including the global region-based model in the proposed method. Both the local and global region-based energy functions in the proposed model drag contours toward the accurate object boundaries with precision. Each of the local and global region-based parts are parameterized with weight coefficients, based on image complexity, to modulate two parts. The proposed hybrid model is strongly capable of detecting region of interests (ROIs) in the presence of complex object boundaries and noise, as its local region-based part comprises bias field. Moreover, the proposed method includes a new bias field (NBF) initialization and eliminates the dependence over the initial contour position. Experimental results on synthetic and real-world images, produced by the proposed model, and comparative analysis with previous state-of-the-art methods confirm its superior performance in terms of both time efficiency and segmentation accuracy