Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

An occam Style Communications System for UNIX Networks

This document describes the design of a communications system which provides occam style communications primitives under a Unix environment, using TCP/IP protocols, and any number of other protocols deemed suitable as underlying transport layers. The system will integrate with a low overhead scheduler/kernel without incurring significant costs to the execution of processes within the run time environment. A survey of relevant occam and occam3 features and related research is followed by a look at the Unix and TCP/IP facilities which determine our working constraints, and a description of the T9000 transputer's Virtual Channel Processor, which was instrumental in our formulation. Drawing from the information presented here, a design for the communications system is subsequently proposed. Finally, a preliminary investigation of methods for lightweight access control to shared resources in an environment which does not provide support for critical sections, semaphores, or busy waiting, is made. This is presented with relevance to mutual exclusion problems which arise within the proposed design. Future directions for the evolution of this project are discussed in conclusion

Expanding sensor networks to automate knowledge acquisition

The availability of accurate, low-cost sensors to scientists has resulted in widespread deployment in a variety of sporting and health environments. The sensor data output is often in a raw, proprietary or unstructured format. As a result, it is often difficult to query multiple sensors for complex properties or actions. In our research, we deploy a heterogeneous sensor network to detect the various biological and physiological properties in athletes during training activities. The goal for exercise physiologists is to quickly identify key intervals in exercise such as moments of stress or fatigue. This is not currently possible because of low level sensors and a lack of query language support. Thus, our motivation is to expand the sensor network with a contextual layer that enriches raw sensor data, so that it can be exploited by a high level query language. To achieve this, the domain expert specifies events in a tradiational event-condition-action format to deliver the required contextual enrichment

Cognitive Radio for Emergency Networks

In the scope of the Adaptive Ad-hoc Freeband (AAF) project, an emergency network built on top of Cognitive Radio is proposed to alleviate the spectrum shortage problem which is the major limitation for emergency networks. Cognitive Radio has been proposed as a promising technology to solve todayâ?~B??~D?s spectrum scarcity problem by allowing a secondary user in the non-used parts of the spectrum that aactully are assigned to primary services. Cognitive Radio has to work in different frequency bands and various wireless channels and supports multimedia services. A heterogenous reconfigurable System-on-Chip (SoC) architecture is proposed to enable the evolution from the traditional software defined radio to Cognitive Radio

The application of artificial intelligence techniques to large distributed networks

Data accessibility and transfer of information, including the land resources information system pilot, are structured as large computer information networks. These pilot efforts include the reduction of the difficulty to find and use data, reducing processing costs, and minimize incompatibility between data sources. Artificial Intelligence (AI) techniques were suggested to achieve these goals. The applicability of certain AI techniques are explored in the context of distributed problem solving systems and the pilot land data system (PLDS). The topics discussed include: PLDS and its data processing requirements, expert systems and PLDS, distributed problem solving systems, AI problem solving paradigms, query processing, and distributed data bases