10,756 research outputs found

    XML in Motion from Genome to Drug

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    Information technology (IT) has emerged as a central to the solution of contemporary genomics and drug discovery problems. Researchers involved in genomics, proteomics, transcriptional profiling, high throughput structure determination, and in other sub-disciplines of bioinformatics have direct impact on this IT revolution. As the full genome sequences of many species, data from structural genomics, micro-arrays, and proteomics became available, integration of these data to a common platform require sophisticated bioinformatics tools. Organizing these data into knowledgeable databases and developing appropriate software tools for analyzing the same are going to be major challenges. XML (eXtensible Markup Language) forms the backbone of biological data representation and exchange over the internet, enabling researchers to aggregate data from various heterogeneous data resources. The present article covers a comprehensive idea of the integration of XML on particular type of biological databases mainly dealing with sequence-structure-function relationship and its application towards drug discovery. This e-medical science approach should be applied to other scientific domains and the latest trend in semantic web applications is also highlighted

    Linked education: interlinking educational resources and the web of data

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    Research on interoperability of technology-enhanced learning (TEL) repositories throughout the last decade has led to a fragmented landscape of competing approaches, such as metadata schemas and interface mechanisms. However, so far Web-scale integration of resources is not facilitated, mainly due to the lack of take-up of shared principles, datasets and schemas. On the other hand, the Linked Data approach has emerged as the de-facto standard for sharing data on the Web and offers a large potential to solve interoperability issues in the field of TEL. In this paper, we describe a general approach to exploit the wealth of already existing TEL data on the Web by allowing its exposure as Linked Data and by taking into account automated enrichment and interlinking techniques to provide rich and well-interlinked data for the educational domain. This approach has been implemented in the context of the mEducator project where data from a number of open TEL data repositories has been integrated, exposed and enriched by following Linked Data principles

    Toward Self-Organising Service Communities

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    This paper discusses a framework in which catalog service communities are built, linked for interaction, and constantly monitored and adapted over time. A catalog service community (represented as a peer node in a peer-to-peer network) in our system can be viewed as domain specific data integration mediators representing the domain knowledge and the registry information. The query routing among communities is performed to identify a set of data sources that are relevant to answering a given query. The system monitors the interactions between the communities to discover patterns that may lead to restructuring of the network (e.g., irrelevant peers removed, new relationships created, etc.)

    OCRIS : online catalogue and repository interoperability study. Final report

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    The aims and objectives of OCRIS were to: • Survey the extent to which repository content is in scope for institutional library OPACs, and the extent to which it is already recorded there; • Examine the interoperability of OPAC and repository software for the exchange of metadata and other information; • List the various services to institutional managers, researchers, teachers and learners offered respectively by OPACs and repositories; • Identify the potential for improvements in the links (e.g. using link resolver technology) from repositories and/or OPACs to other institutional services, such as finance or research administration; • Make recommendations for the development of possible further links between library OPACs and institutional repositories, identifying the benefits to relevant stakeholder groups

    Towards a mobile computing middleware: a synergy of reflection and mobile code techniques

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    The increasing popularity of wireless devices, such as mobile phones, personal digital assistants, watches and the like. is enabling new classes of applications that present challenging problems to designers. Applications have to be aware of, and adapt to, frequent variations in the context of execution, such as fluctuating network bandwidth, decreasing batten, power, changes in location or device capabilities, and so on. In this paper, we argue that middleware solutions for wired distributed systems cannot be used in a mobile setting, as the principle of transparency that has driven their design runs counter to the new degrees of awareness imposed by mobility: We propose a synergy of reflection and code mobility as a means for middleware to give applications the desired level of flexibility to react to changes happening in the environment, including those that have not necessarily been foreseen by middleware designers. We ruse the sharing and processing of images as an application scenario to highlight the advantages of our approach

    1st INCF Workshop on Sustainability of Neuroscience Databases

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    The goal of the workshop was to discuss issues related to the sustainability of neuroscience databases, identify problems and propose solutions, and formulate recommendations to the INCF. The report summarizes the discussions of invited participants from the neuroinformatics community as well as from other disciplines where sustainability issues have already been approached. The recommendations for the INCF involve rating, ranking, and supporting database sustainability

    The Open Practises E-Science Network (OPEN)

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    A grant proposal submitted for support to fund a research network focussed on identifying and dealing with the practical issues of enabling open practise in research. The text of the proposal was written by a large number of people and coordinated by Cameron Neylon
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