Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality

The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.Comment: Final, revised version. 13 pages. Please see Nucleic Acids open access article for higher resolution figure

Greedy Forwarding in Dynamic Scale-Free Networks Embedded in Hyperbolic Metric Spaces

We show that complex (scale-free) network topologies naturally emerge from hyperbolic metric spaces. Hyperbolic geometry facilitates maximally efficient greedy forwarding in these networks. Greedy forwarding is topology-oblivious. Nevertheless, greedy packets find their destinations with 100% probability following almost optimal shortest paths. This remarkable efficiency sustains even in highly dynamic networks. Our findings suggest that forwarding information through complex networks, such as the Internet, is possible without the overhead of existing routing protocols, and may also find practical applications in overlay networks for tasks such as application-level routing, information sharing, and data distribution