Real-time human ambulation, activity, and physiological monitoring:taxonomy of issues, techniques, applications, challenges and limitations

Automated methods of real-time, unobtrusive, human ambulation, activity, and wellness monitoring and data analysis using various algorithmic techniques have been subjects of intense research. The general aim is to devise effective means of addressing the demands of assisted living, rehabilitation, and clinical observation and assessment through sensor-based monitoring. The research studies have resulted in a large amount of literature. This paper presents a holistic articulation of the research studies and offers comprehensive insights along four main axes: distribution of existing studies; monitoring device framework and sensor types; data collection, processing and analysis; and applications, limitations and challenges. The aim is to present a systematic and most complete study of literature in the area in order to identify research gaps and prioritize future research directions

Flexible dual-diversity wearable wireless node integrated on a dual-polarised textile patch antenna

A new textile wearable wireless node, for operation in the 2.45 GHz industrial, scientific and medical (ISM) band, is proposed. It consists of a dual-polarised textile patch antenna with integrated microcontroller, sensor, memory and transceiver with receive diversity. Integrated into a garment, the flexible unit may serve for fall detection, as well as for patient or rescue-worker monitoring. Fragile and lossy interconnections are eliminated. They are replaced by very short radiofrequency signal paths in the antenna feed plane, reducing electromagnetic compatibility and signal integrity problems. The compact and flexible module combines sensing and wireless channel monitoring functionality with reliable and energy-efficient off-body wireless communication capability, by fully exploiting dual polarisation diversity. By integrating a battery, a fully autonomous and flexible system is obtained. This novel textile wireless node was validated, both in flat and bent state, in the anechoic chamber, assessing the characteristics of the integrated system in free-space conditions. Moreover, its performance was verified in various real-world conditions, integrated into a firefighter garment, and used as an autonomous body-centric measurement device

Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. Challenges of data safety, quality, and privacy and regulatory requirements need to be addressed by future smart sensor technologies. When these requirements are satisfied, these technologies will provide access to truly user relevant outcomes and broader cohorts of participants than currently sampled in clinical trials

Wearable sensors system for an improved analysis of freezing of gait in Parkinson's disease using electromyography and inertial signals

We propose a wearable sensor system for automatic, continuous and ubiquitous analysis of Freezing of Gait (FOG), in patients affected by Parkinson's disease. FOG is an unpredictable gait disorder with different clinical manifestations, as the trembling and the shuffling-like phenotypes, whose underlying pathophysiology is not fully understood yet. Typical trembling-like subtype features are lack of postural adaptation and abrupt trunk inclination, which in general can increase the fall probability. The targets of this work are detecting the FOG episodes, distinguishing the phenotype and analyzing the muscle activity during and outside FOG, toward a deeper insight in the disorder pathophysiology and the assessment of the fall risk associated to the FOG subtype. To this aim, gyroscopes and surface electromyography integrated in wearable devices sense simultaneously movements and action potentials of antagonist leg muscles. Dedicated algorithms allow the timely detection of the FOG episode and, for the first time, the automatic distinction of the FOG phenotypes, which can enable associating a fall risk to the subtype. Thanks to the possibility of detecting muscles contractions and stretching exactly during FOG, a deeper insight into the pathophysiological underpinnings of the different phenotypes can be achieved, which is an innovative approach with respect to the state of art