Multimodal Multipart Learning for Action Recognition in Depth Videos

The articulated and complex nature of human actions makes the task of action recognition difficult. One approach to handle this complexity is dividing it to the kinetics of body parts and analyzing the actions based on these partial descriptors. We propose a joint sparse regression based learning method which utilizes the structured sparsity to model each action as a combination of multimodal features from a sparse set of body parts. To represent dynamics and appearance of parts, we employ a heterogeneous set of depth and skeleton based features. The proper structure of multimodal multipart features are formulated into the learning framework via the proposed hierarchical mixed norm, to regularize the structured features of each part and to apply sparsity between them, in favor of a group feature selection. Our experimental results expose the effectiveness of the proposed learning method in which it outperforms other methods in all three tested datasets while saturating one of them by achieving perfect accuracy

Nuclei/Cell Detection in Microscopic Skeletal Muscle Fiber Images and Histopathological Brain Tumor Images Using Sparse Optimizations

Nuclei/Cell detection is usually a prerequisite procedure in many computer-aided biomedical image analysis tasks. In this thesis we propose two automatic nuclei/cell detection frameworks. One is for nuclei detection in skeletal muscle fiber images and the other is for brain tumor histopathological images. For skeletal muscle fiber images, the major challenges include: i) shape and size variations of the nuclei, ii) overlapping nuclear clumps, and iii) a series of z-stack images with out-of-focus regions. We propose a novel automatic detection algorithm consisting of the following components: 1) The original z-stack images are first converted into one all-in-focus image. 2) A sufficient number of hypothetical ellipses are then generated for each nuclei contour. 3) Next, a set of representative training samples and discriminative features are selected by a two-stage sparse model. 4) A classifier is trained using the refined training data. 5) Final nuclei detection is obtained by mean-shift clustering based on inner distance. The proposed method was tested on a set of images containing over 1500 nuclei. The results outperform the current state-of-the-art approaches. For brain tumor histopathological images, the major challenges are to handle significant variations in cell appearance and to split touching cells. The proposed novel automatic cell detection consists of: 1) Sparse reconstruction for splitting touching cells. 2) Adaptive dictionary learning for handling cell appearance variations. The proposed method was extensively tested on a data set with over 2000 cells. The result outperforms other state-of-the-art algorithms with F1 score = 0.96

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common type of leukemia. The Cancer Genome Atlas Research Network has demonstrated the increasing genomic complexity of acute myeloid leukemia (AML). In addition, the network has facilitated our understanding of the molecular events leading to this deadly form of malignancy for which the prognosis has not improved over past decades. AML is a highly heterogeneous disease, and cytogenetics and molecular analysis of the various chromosome aberrations including deletions, duplications, aneuploidy, balanced reciprocal translocations and fusion of transcription factor genes and tyrosine kinases has led to better understanding and identification of subgroups of AML with different prognoses. Furthermore, molecular classification based on mRNA expression profiling has facilitated identification of novel subclasses and defined high-, poor-risk AML based on specific molecular signatures. However, despite increased understanding of AML genetics, the outcome for AML patients whose number is likely to rise as the population ages, has not changed significantly. Until it does, further investigation of the genomic complexity of the disease and advances in drug development are needed. In this review, leading AML clinicians and research investigators provide an up-to-date understanding of the molecular biology of the disease addressing advances in diagnosis, classification, prognostication and therapeutic strategies that may have significant promise and impact on overall patient survival

FACE RECOGNITION AND VERIFICATION IN UNCONSTRAINED ENVIRIONMENTS

Face recognition has been a long standing problem in computer vision. General face recognition is challenging because of large appearance variability due to factors including pose, ambient lighting, expression, size of the face, age, and distance from the camera, etc. There are very accurate techniques to perform face recognition in controlled environments, especially when large numbers of samples are available for each face (individual). However, face identification under uncontrolled( unconstrained) environments or with limited training data is still an unsolved problem. There are two face recognition tasks: face identification (who is who in a probe face set, given a gallery face set) and face verification (same or not, given two faces). In this work, we study both face identification and verification in unconstrained environments. Firstly, we propose a face verification framework that combines Partial Least Squares (PLS) and the One-Shot similarity model[1]. The idea is to describe a face with a large feature set combining shape, texture and color information. PLS regression is applied to perform multi-channel feature weighting on this large feature set. Finally the PLS regression is used to compute the similarity score of an image pair by One-Shot learning (using a fixed negative set). Secondly, we study face identification with image sets, where the gallery and probe are sets of face images of an individual. We model a face set by its covariance matrix (COV) which is a natural 2nd-order statistic of a sample set.By exploring an efficient metric for the SPD matrices, i.e., Log-Euclidean Distance (LED), we derive a kernel function that explicitly maps the covariance matrix from the Riemannian manifold to Euclidean space. Then, discriminative learning is performed on the COV manifold: the learning aims to maximize the between-class COV distance and minimize the within-class COV distance. Sparse representation and dictionary learning have been widely used in face recognition, especially when large numbers of samples are available for each face (individual). Sparse coding is promising since it provides a more stable and discriminative face representation. In the last part of our work, we explore sparse coding and dictionary learning for face verification application. More specifically, in one approach, we apply sparse representations to face verification in two ways via a fix reference set as dictionary. In the other approach, we propose a dictionary learning framework with explicit pairwise constraints, which unifies the discriminative dictionary learning for pair matching (face verification) and classification (face recognition) problems