Anatomical Priors in Convolutional Networks for Unsupervised Biomedical Segmentation

We consider the problem of segmenting a biomedical image into anatomical regions of interest. We specifically address the frequent scenario where we have no paired training data that contains images and their manual segmentations. Instead, we employ unpaired segmentation images to build an anatomical prior. Critically these segmentations can be derived from imaging data from a different dataset and imaging modality than the current task. We introduce a generative probabilistic model that employs the learned prior through a convolutional neural network to compute segmentations in an unsupervised setting. We conducted an empirical analysis of the proposed approach in the context of structural brain MRI segmentation, using a multi-study dataset of more than 14,000 scans. Our results show that an anatomical prior can enable fast unsupervised segmentation which is typically not possible using standard convolutional networks. The integration of anatomical priors can facilitate CNN-based anatomical segmentation in a range of novel clinical problems, where few or no annotations are available and thus standard networks are not trainable. The code is freely available at http://github.com/adalca/neuron.Comment: Presented at CVPR 2018. IEEE CVPR proceedings pp. 9290-929

Learning Face Age Progression: A Pyramid Architecture of GANs

The two underlying requirements of face age progression, i.e. aging accuracy and identity permanence, are not well studied in the literature. In this paper, we present a novel generative adversarial network based approach. It separately models the constraints for the intrinsic subject-specific characteristics and the age-specific facial changes with respect to the elapsed time, ensuring that the generated faces present desired aging effects while simultaneously keeping personalized properties stable. Further, to generate more lifelike facial details, high-level age-specific features conveyed by the synthesized face are estimated by a pyramidal adversarial discriminator at multiple scales, which simulates the aging effects in a finer manner. The proposed method is applicable to diverse face samples in the presence of variations in pose, expression, makeup, etc., and remarkably vivid aging effects are achieved. Both visual fidelity and quantitative evaluations show that the approach advances the state-of-the-art.Comment: CVPR 2018. V4 and V2 are the same, i.e. the conference version; V3 is a related but different work, which is mistakenly submitted and will be submitted as a new arXiv pape