15,513 research outputs found
Neuron Segmentation Using Deep Complete Bipartite Networks
In this paper, we consider the problem of automatically segmenting neuronal
cells in dual-color confocal microscopy images. This problem is a key task in
various quantitative analysis applications in neuroscience, such as tracing
cell genesis in Danio rerio (zebrafish) brains. Deep learning, especially using
fully convolutional networks (FCN), has profoundly changed segmentation
research in biomedical imaging. We face two major challenges in this problem.
First, neuronal cells may form dense clusters, making it difficult to correctly
identify all individual cells (even to human experts). Consequently,
segmentation results of the known FCN-type models are not accurate enough.
Second, pixel-wise ground truth is difficult to obtain. Only a limited amount
of approximate instance-wise annotation can be collected, which makes the
training of FCN models quite cumbersome. We propose a new FCN-type deep
learning model, called deep complete bipartite networks (CB-Net), and a new
scheme for leveraging approximate instance-wise annotation to train our
pixel-wise prediction model. Evaluated using seven real datasets, our proposed
new CB-Net model outperforms the state-of-the-art FCN models and produces
neuron segmentation results of remarkable qualityComment: miccai 201
Cancer diagnosis using deep learning: A bibliographic review
In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements
Theoretical Interpretations and Applications of Radial Basis Function Networks
Medical applications usually used Radial Basis Function Networks just as Artificial Neural Networks. However, RBFNs are Knowledge-Based Networks that can be interpreted in several way: Artificial Neural Networks, Regularization Networks, Support Vector Machines, Wavelet Networks, Fuzzy Controllers, Kernel Estimators, Instanced-Based Learners. A survey of their interpretations and of their corresponding learning algorithms is provided as well as a brief survey on dynamic learning algorithms. RBFNs' interpretations can suggest applications that are particularly interesting in medical domains
Application of a Mamdani-type fuzzy rule-based system to segment periventricular cerebral veins in susceptibility-weighted images
This paper presents an algorithm designed to segment veins in the periventricular region of the brain in susceptibility-weighted magnetic resonance images. The proposed algorithm is based on a Mamdani-type fuzzy rule-based system that enables enhancement of veins within periventricular regions of interest as the first step. Segmentation is achieved after determining the cut-off value providing the best trade-off between sensitivity and specificity to establish the suitability of each pixel to belong to a cerebral vein. Performance of the algorithm in
susceptibility-weighted images acquired in healthy volunteers showed very good segmentation, with a small number of false positives. The results were not affected by small changes in the size and location of the regions of interest. The
algorithm also enabled detection of differences in the visibility of periventricular veins between healthy subjects and multiple sclerosis patients. © Springer International Publishing Switzerland 2016.Postprint (author's final draft
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