Fuzzy-Granular Based Data Mining for Effective Decision Support in Biomedical Applications

Due to complexity of biomedical problems, adaptive and intelligent knowledge discovery and data mining systems are highly needed to help humans to understand the inherent mechanism of diseases. For biomedical classification problems, typically it is impossible to build a perfect classifier with 100% prediction accuracy. Hence a more realistic target is to build an effective Decision Support System (DSS). In this dissertation, a novel adaptive Fuzzy Association Rules (FARs) mining algorithm, named FARM-DS, is proposed to build such a DSS for binary classification problems in the biomedical domain. Empirical studies show that FARM-DS is competitive to state-of-the-art classifiers in terms of prediction accuracy. More importantly, FARs can provide strong decision support on disease diagnoses due to their easy interpretability. This dissertation also proposes a fuzzy-granular method to select informative and discriminative genes from huge microarray gene expression data. With fuzzy granulation, information loss in the process of gene selection is decreased. As a result, more informative genes for cancer classification are selected and more accurate classifiers can be modeled. Empirical studies show that the proposed method is more accurate than traditional algorithms for cancer classification. And hence we expect that genes being selected can be more helpful for further biological studies

An overview of recent distributed algorithms for learning fuzzy models in Big Data classification

AbstractNowadays, a huge amount of data are generated, often in very short time intervals and in various formats, by a number of different heterogeneous sources such as social networks and media, mobile devices, internet transactions, networked devices and sensors. These data, identified as Big Data in the literature, are characterized by the popular Vs features, such as Value, Veracity, Variety, Velocity and Volume. In particular, Value focuses on the useful knowledge that may be mined from data. Thus, in the last years, a number of data mining and machine learning algorithms have been proposed to extract knowledge from Big Data. These algorithms have been generally implemented by using ad-hoc programming paradigms, such as MapReduce, on specific distributed computing frameworks, such as Apache Hadoop and Apache Spark. In the context of Big Data, fuzzy models are currently playing a significant role, thanks to their capability of handling vague and imprecise data and their innate characteristic to be interpretable. In this work, we give an overview of the most recent distributed learning algorithms for generating fuzzy classification models for Big Data. In particular, we first show some design and implementation details of these learning algorithms. Thereafter, we compare them in terms of accuracy and interpretability. Finally, we argue about their scalability

Representation of maxitive measures: an overview

Idempotent integration is an analogue of Lebesgue integration where $\sigma$-maxitive measures replace $\sigma$-additive measures. In addition to reviewing and unifying several Radon--Nikodym like theorems proven in the literature for the idempotent integral, we also prove new results of the same kind.Comment: 40 page

Theoretical Interpretations and Applications of Radial Basis Function Networks

Medical applications usually used Radial Basis Function Networks just as Artificial Neural Networks. However, RBFNs are Knowledge-Based Networks that can be interpreted in several way: Artificial Neural Networks, Regularization Networks, Support Vector Machines, Wavelet Networks, Fuzzy Controllers, Kernel Estimators, Instanced-Based Learners. A survey of their interpretations and of their corresponding learning algorithms is provided as well as a brief survey on dynamic learning algorithms. RBFNs' interpretations can suggest applications that are particularly interesting in medical domains