85,980 research outputs found

    Machine Learning and Integrative Analysis of Biomedical Big Data.

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    Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

    A Framework for XML-based Integration of Data, Visualization and Analysis in a Biomedical Domain

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    Biomedical data are becoming increasingly complex and heterogeneous in nature. The data are stored in distributed information systems, using a variety of data models, and are processed by increasingly more complex tools that analyze and visualize them. We present in this paper our framework for integrating biomedical research data and tools into a unique Web front end. Our framework is applied to the University of Washington’s Human Brain Project. SpeciïŹcally, we present solutions to four integration tasks: deïŹnition of complex mappings from relational sources to XML, distributed XQuery processing, generation of heterogeneous output formats, and the integration of heterogeneous data visualization and analysis tools

    Internet of robotic things : converging sensing/actuating, hypoconnectivity, artificial intelligence and IoT Platforms

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    The Internet of Things (IoT) concept is evolving rapidly and influencing newdevelopments in various application domains, such as the Internet of MobileThings (IoMT), Autonomous Internet of Things (A-IoT), Autonomous Systemof Things (ASoT), Internet of Autonomous Things (IoAT), Internetof Things Clouds (IoT-C) and the Internet of Robotic Things (IoRT) etc.that are progressing/advancing by using IoT technology. The IoT influencerepresents new development and deployment challenges in different areassuch as seamless platform integration, context based cognitive network integration,new mobile sensor/actuator network paradigms, things identification(addressing, naming in IoT) and dynamic things discoverability and manyothers. The IoRT represents new convergence challenges and their need to be addressed, in one side the programmability and the communication ofmultiple heterogeneous mobile/autonomous/robotic things for cooperating,their coordination, configuration, exchange of information, security, safetyand protection. Developments in IoT heterogeneous parallel processing/communication and dynamic systems based on parallelism and concurrencyrequire new ideas for integrating the intelligent “devices”, collaborativerobots (COBOTS), into IoT applications. Dynamic maintainability, selfhealing,self-repair of resources, changing resource state, (re-) configurationand context based IoT systems for service implementation and integrationwith IoT network service composition are of paramount importance whennew “cognitive devices” are becoming active participants in IoT applications.This chapter aims to be an overview of the IoRT concept, technologies,architectures and applications and to provide a comprehensive coverage offuture challenges, developments and applications

    Dynamic integration of context model constraints in web service processes

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    Autonomic Web service composition has been a challenging topic for some years. The context in which composition takes places determines essential aspects. A context model can provide meaningful composition information for services process composition. An ontology-based approach for context information integration is the basis of a constraint approach to dynamically integrate context validation into service processes. The dynamic integration of context constraints into an orchestrated service process is a necessary direction to achieve autonomic service composition

    Towards Semantic Integration of Heterogeneous Sensor Data with Indigenous Knowledge for Drought Forecasting

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    In the Internet of Things (IoT) domain, various heterogeneous ubiquitous devices would be able to connect and communicate with each other seamlessly, irrespective of the domain. Semantic representation of data through detailed standardized annotation has shown to improve the integration of the interconnected heterogeneous devices. However, the semantic representation of these heterogeneous data sources for environmental monitoring systems is not yet well supported. To achieve the maximum benefits of IoT for drought forecasting, a dedicated semantic middleware solution is required. This research proposes a middleware that semantically represents and integrates heterogeneous data sources with indigenous knowledge based on a unified ontology for an accurate IoT-based drought early warning system (DEWS).Comment: 5 pages, 3 figures, In Proceedings of the Doctoral Symposium of the 16th International Middleware Conference (Middleware Doct Symposium 2015), Ivan Beschastnikh and Wouter Joosen (Eds.). ACM, New York, NY, US

    Linked education: interlinking educational resources and the web of data

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    Research on interoperability of technology-enhanced learning (TEL) repositories throughout the last decade has led to a fragmented landscape of competing approaches, such as metadata schemas and interface mechanisms. However, so far Web-scale integration of resources is not facilitated, mainly due to the lack of take-up of shared principles, datasets and schemas. On the other hand, the Linked Data approach has emerged as the de-facto standard for sharing data on the Web and offers a large potential to solve interoperability issues in the field of TEL. In this paper, we describe a general approach to exploit the wealth of already existing TEL data on the Web by allowing its exposure as Linked Data and by taking into account automated enrichment and interlinking techniques to provide rich and well-interlinked data for the educational domain. This approach has been implemented in the context of the mEducator project where data from a number of open TEL data repositories has been integrated, exposed and enriched by following Linked Data principles
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