5,584 research outputs found

    An investigation of entorhinal spatial representations in self-localisation behaviours

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    Spatial-modulated cells of the medial entorhinal cortex (MEC) and neighbouring cortices are thought to provide the neural substrate for self-localisation behaviours. These cells include grid cells of the MEC which are thought to compute path integration operations to update self-location estimates. In order to read this grid code, downstream cells are thought to reconstruct a positional estimate as a simple rate-coded representation of space. Here, I show the coding scheme of grid cell and putative readout cells recorded from mice performing a virtual reality (VR) linear location task which engaged mice in both beaconing and path integration behaviours. I found grid cells can encode two unique coding schemes on the linear track, namely a position code which reflects periodic grid fields anchored to salient features of the track and a distance code which reflects periodic grid fields without this anchoring. Grid cells were found to switch between these coding schemes within sessions. When grid cells were encoding position, mice performed better at trials that required path integration but not on trials that required beaconing. This result provides the first mechanistic evidence linking grid cell activity to path integration-dependent behaviour. Putative readout cells were found in the form of ramp cells which fire proportionally as a function of location in defined regions of the linear track. This ramping activity was found to be primarily explained by track position rather than other kinematic variables like speed and acceleration. These representations were found to be maintained across both trial types and outcomes indicating they likely result from recall of the track structure. Together, these results support the functional importance of grid and ramp cells for self-localisation behaviours. Future investigations will look into the coherence between these two neural populations, which may together form a complete neural system for coding and decoding self-location in the brain

    Technology for Low Resolution Space Based RSO Detection and Characterisation

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    Space Situational Awareness (SSA) refers to all activities to detect, identify and track objects in Earth orbit. SSA is critical to all current and future space activities and protect space assets by providing access control, conjunction warnings, and monitoring status of active satellites. Currently SSA methods and infrastructure are not sufficient to account for the proliferations of space debris. In response to the need for better SSA there has been many different areas of research looking to improve SSA most of the requiring dedicated ground or space-based infrastructure. In this thesis, a novel approach for the characterisation of RSO’s (Resident Space Objects) from passive low-resolution space-based sensors is presented with all the background work performed to enable this novel method. Low resolution space-based sensors are common on current satellites, with many of these sensors being in space using them passively to detect RSO’s can greatly augment SSA with out expensive infrastructure or long lead times. One of the largest hurtles to overcome with research in the area has to do with the lack of publicly available labelled data to test and confirm results with. To overcome this hurtle a simulation software, ORBITALS, was created. To verify and validate the ORBITALS simulator it was compared with the Fast Auroral Imager images, which is one of the only publicly available low-resolution space-based images found with auxiliary data. During the development of the ORBITALS simulator it was found that the generation of these simulated images are computationally intensive when propagating the entire space catalog. To overcome this an upgrade of the currently used propagation method, Specialised General Perturbation Method 4th order (SGP4), was performed to allow the algorithm to run in parallel reducing the computational time required to propagate entire catalogs of RSO’s. From the results it was found that the standard facet model with a particle swarm optimisation performed the best estimating an RSO’s attitude with a 0.66 degree RMSE accuracy across a sequence, and ~1% MAPE accuracy for the optical properties. This accomplished this thesis goal of demonstrating the feasibility of low-resolution passive RSO characterisation from space-based platforms in a simulated environment

    Specificity of the innate immune responses to different classes of non-tuberculous mycobacteria

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    Mycobacterium avium is the most common nontuberculous mycobacterium (NTM) species causing infectious disease. Here, we characterized a M. avium infection model in zebrafish larvae, and compared it to M. marinum infection, a model of tuberculosis. M. avium bacteria are efficiently phagocytosed and frequently induce granuloma-like structures in zebrafish larvae. Although macrophages can respond to both mycobacterial infections, their migration speed is faster in infections caused by M. marinum. Tlr2 is conservatively involved in most aspects of the defense against both mycobacterial infections. However, Tlr2 has a function in the migration speed of macrophages and neutrophils to infection sites with M. marinum that is not observed with M. avium. Using RNAseq analysis, we found a distinct transcriptome response in cytokine-cytokine receptor interaction for M. avium and M. marinum infection. In addition, we found differences in gene expression in metabolic pathways, phagosome formation, matrix remodeling, and apoptosis in response to these mycobacterial infections. In conclusion, we characterized a new M. avium infection model in zebrafish that can be further used in studying pathological mechanisms for NTM-caused diseases

    A Simulation of the Impacts of Climate Change on Civil Aircraft Takeoff Performance

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    Climate change affects the near-surface environmental conditions that prevail at airports worldwide. Among these, air density and headwind speed are major determinants of takeoff performance, and their sensitivity to global warming carries potential operational and economic implications for the commercial air transport industry. Previous archival and prospective research observed a weakening in headwind strength and predicted an increase in near-surface temperatures, respectively, resulting in an increase in takeoff distances and weight restrictions. The main purpose of the present study was to update and generalize the extant prospective research using a more representative sample of worldwide airports, a wider range of climate scenarios, and next-generation climate models. The research questions included how much additional thrust and payload removal will be required to offset the centurial changes in takeoff conditions. This study relied on a quantitative method using the simulation instrument. Forecast climate data corresponding to four shared socioeconomic pathways (SSP1‒2.6, SSP2‒4.5, SSP3‒7.0, and SSP5‒8.5) over the available 2015‒2100 period were sourced from a high-resolution CMIP6 global circulation model. These data were used to characterize the six-hourly near-surface environmental conditions prevailing at all 881 airports worldwide having at least one million passengers in pre-COVID‒19 traffic. The missing air density was iii numerically derived from the air temperature, pressure, and humidity variables, while the headwind speed for each airport’s active runway configuration was triangulated from the wind vector components. Separately, a direct takeoff-dynamics simulation model was developed from first principles and calibrated against published performance data under international standard atmospheric conditions for two narrowbody and two widebody aircraft. The model was used to simulate 1.8 billion unique takeoffs, each initiated at 75% of maximum takeoff thrust and 100% of maximum takeoff mass. When the resulting takeoff distance required exceeded that available, the takeoff thrust was gradually increased to 100%, after which the takeoff mass was gradually decreased to an estimated breakeven load factor. In total, 65 billion takeoff iterations were simulated. Longitudinal changes to takeoff thrust, distance, and payload were recorded and examined by aircraft type, climate scenario, and climate zone. The results show that despite a marked centurial increase in the global mean air temperature of 9.4%‒18.0% relative to the year 2015 under SSP2‒4.5 and SSP3‒7.0, air density will only decrease by 0.6%‒1.1% due to its weak sensitivity to temperature. Likewise, mean headwinds were observed to remain almost unchanged relative to the 2015 baseline. As a result, the global mean takeoff thrust was found to increase by no more than 0.3 percentage point while payload removals did not exceed 1.1 passenger. Significant deviations from the mean were observed at climatic outlier airports, including those located around the Siberian plateau, where takeoff operations may become more difficult. This study contributes to the air transport climate adaption body of knowledge by providing contrasting results relative to earlier research that reported strong impacts of global warming on takeoff performance

    One-sided differentiability: a challenge for computer algebra systems

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    Computer Algebra Systems (CASs) are extremely powerful and widely used digital tools. Focusing on differentiation, CASs include a command that computes the derivative of functions in one variable (and also the partial derivative of functions in several variables). We will focus in this article on real-valued functions of one real variable. Since CASs usually compute the derivative of real-valued functions as a whole, the value of the computed derivative at points where the left derivative and the right derivative are different (that we will call conflicting points) should be something like "undefined", although this isn't always the case: the output could strongly differ depending on the chosen CAS. We have analysed and compared in this article how some well-known CASs behave when addressing differentiation at the conflicting points of five different functions chosen by the authors. Finally, the ability for calculating one-sided limits of CASs allows to directly compute the result in these cumbersome cases using the formal definition of one-sided derivative, which we have also analysed and compared for the selected CASs. Regarding teaching, this is an important issue, as it is a topic of Secondary Education and nowadays the use of CASs as an auxiliary digital tool for teaching mathematics is very common

    Tiny Machine Learning Environment: Enabling Intelligence on Constrained Devices

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    Running machine learning algorithms (ML) on constrained devices at the extreme edge of the network is problematic due to the computational overhead of ML algorithms, available resources on the embedded platform, and application budget (i.e., real-time requirements, power constraints, etc.). This required the development of specific solutions and development tools for what is now referred to as TinyML. In this dissertation, we focus on improving the deployment and performance of TinyML applications, taking into consideration the aforementioned challenges, especially memory requirements. This dissertation contributed to the construction of the Edge Learning Machine environment (ELM), a platform-independent open source framework that provides three main TinyML services, namely shallow ML, self-supervised ML, and binary deep learning on constrained devices. In this context, this work includes the following steps, which are reflected in the thesis structure. First, we present the performance analysis of state of the art shallow ML algorithms including dense neural networks, implemented on mainstream microcontrollers. The comprehensive analysis in terms of algorithms, hardware platforms, datasets, pre-processing techniques, and configurations shows similar performance results compared to a desktop machine and highlights the impact of these factors on overall performance. Second, despite the assumption that TinyML only permits models inference provided by the scarcity of resources, we have gone a step further and enabled self-supervised on-device training on microcontrollers and tiny IoT devices by developing the Autonomous Edge Pipeline (AEP) system. AEP achieves comparable accuracy compared to the typical TinyML paradigm, i.e., models trained on resource-abundant devices and then deployed on microcontrollers. Next, we present the development of a memory allocation strategy for convolutional neural networks (CNNs) layers, that optimizes memory requirements. This approach reduces the memory footprint without affecting accuracy nor latency. Moreover, e-skin systems share the main requirements of the TinyML fields: enabling intelligence with low memory, low power consumption, and low latency. Therefore, we designed an efficient Tiny CNN architecture for e-skin applications. The architecture leverages the memory allocation strategy presented earlier and provides better performance than existing solutions. A major contribution of the thesis is given by CBin-NN, a library of functions for implementing extremely efficient binary neural networks on constrained devices. The library outperforms state of the art NN deployment solutions by drastically reducing memory footprint and inference latency. All the solutions proposed in this thesis have been implemented on representative devices and tested in relevant applications, of which results are reported and discussed. The ELM framework is open source, and this work is clearly becoming a useful, versatile toolkit for the IoT and TinyML research and development community

    Machine Learning Applications for the Study and Control of Quantum Systems

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    In this thesis, I consider the three main paradigms of machine learning – supervised, unsupervised, and reinforcement learning – and explore how each can be employed as a tool to study or control quantum systems. To this end, I adopt classical machine learning methods, but also illustrate how present-day quantum devices and concepts from condensed matter physics can be harnessed to adapt the machine learning models to the physical system being studied. In the first project, I use supervised learning techniques from classical object detection to locate quantum vortices in rotating BoseEinstein condensates. The machine learning model achieves high accuracies even in the presence of noise, which makes it especially suitable for experimental settings. I then move on to the field of unsupervised learning and introduce a quantum anomaly detection framework based on parameterized quantum circuits to map out phase diagrams of quantum many-body systems. The proposed algorithm allows quantum systems to be directly analyzed on a quantum computer without any prior knowledge about its phases. Lastly, I consider two reinforcement learning applications for quantum control. In the first example, I use Q-learning to maximize the entanglement in discrete-time quantum walks. In the final study, I introduce a novel approach for controlling quantum many-body systems by leveraging matrix product states as a trainable machine learning ansatz for the reinforcement learning agent. This framework enables us to reach far larger system sizes than conventional neural network-based approaches.Okinawa Institute of Science and Technology Graduate Universit

    Joe Pawsey and the Founding of Australian Radio Astronomy

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    This open access book is a biography of Joseph L. Pawsey. It examines not only his life but the birth and growth of the field of radio astronomy and the state of science itself in twentieth century Australia. The book explains how an isolated continent with limited resources grew to be one of the leaders in the study of radio astronomy and the design of instruments to do so. Pawsey made a name for himself in the international astronomy community within a decade after WWII and coined the term radio astronomy. His most valuable talent was his ability to recruit and support bright young scientists who became the technical and methodological innovators of the era, building new telescopes from the Mills Cross and Chris (Christiansen) Cross to the Parkes radio telescope. The development of aperture synthesis and the controversy surrounding the cosmological interpretation of the first major survey which resulted in the Sydney research group's disagreements with Nobel laureate Martin Ryle play major roles in this story. This book also shows the connections among prominent astronomers like Oort, Minkowski, Baade, Struve, famous scientists in the UK such as J.A. Ratcliffe, Edward Appleton and Henry Tizard, and the engineers and physicists in Australia who helped develop the field of radio astronomy. Pawsey was appointed the second Director of the National Radio Astronomy Observatory (Green Bank, West Virginia) in October 1961; he died in Sydney at the age of 54 in late November 1962. Upper level students, scientists and historians will find the information, much of it from primary sources, relevant to any study of Joseph L. Pawsey or radio astronomy. This is an open access book

    Exploring Animal Behavior Through Sound: Volume 1

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    This open-access book empowers its readers to explore the acoustic world of animals. By listening to the sounds of nature, we can study animal behavior, distribution, and demographics; their habitat characteristics and needs; and the effects of noise. Sound recording is an efficient and affordable tool, independent of daylight and weather; and recorders may be left in place for many months at a time, continuously collecting data on animals and their environment. This book builds the skills and knowledge necessary to collect and interpret acoustic data from terrestrial and marine environments. Beginning with a history of sound recording, the chapters provide an overview of off-the-shelf recording equipment and analysis tools (including automated signal detectors and statistical methods); audiometric methods; acoustic terminology, quantities, and units; sound propagation in air and under water; soundscapes of terrestrial and marine habitats; animal acoustic and vibrational communication; echolocation; and the effects of noise. This book will be useful to students and researchers of animal ecology who wish to add acoustics to their toolbox, as well as to environmental managers in industry and government

    Fundamentals

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    Volume 1 establishes the foundations of this new field. It goes through all the steps from data collection, their summary and clustering, to different aspects of resource-aware learning, i.e., hardware, memory, energy, and communication awareness. Machine learning methods are inspected with respect to resource requirements and how to enhance scalability on diverse computing architectures ranging from embedded systems to large computing clusters
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