Multiple instance fuzzy inference.

A novel fuzzy learning framework that employs fuzzy inference to solve the problem of multiple instance learning (MIL) is presented. The framework introduces a new class of fuzzy inference systems called Multiple Instance Fuzzy Inference Systems (MI-FIS). Fuzzy inference is a powerful modeling framework that can handle computing with knowledge uncertainty and measurement imprecision effectively. Fuzzy Inference performs a non-linear mapping from an input space to an output space by deriving conclusions from a set of fuzzy if-then rules and known facts. Rules can be identified from expert knowledge, or learned from data. In multiple instance problems, the training data is ambiguously labeled. Instances are grouped into bags, labels of bags are known but not those of individual instances. MIL deals with learning a classifier at the bag level. Over the years, many solutions to this problem have been proposed. However, no MIL formulation employing fuzzy inference exists in the literature. In this dissertation, we introduce multiple instance fuzzy logic that enables fuzzy reasoning with bags of instances. Accordingly, different multiple instance fuzzy inference styles are proposed. The Multiple Instance Mamdani style fuzzy inference (MI-Mamdani) extends the standard Mamdani style inference to compute with multiple instances. The Multiple Instance Sugeno style fuzzy inference (MI-Sugeno) is an extension of the standard Sugeno style inference to handle reasoning with multiple instances. In addition to the MI-FIS inference styles, one of the main contributions of this work is an adaptive neuro-fuzzy architecture designed to handle bags of instances as input and capable of learning from ambiguously labeled data. The proposed architecture, called Multiple Instance-ANFIS (MI-ANFIS), extends the standard Adaptive Neuro Fuzzy Inference System (ANFIS). We also propose different methods to identify and learn fuzzy if-then rules in the context of MIL. In particular, a novel learning algorithm for MI-ANFIS is derived. The learning is achieved by using the backpropagation algorithm to identify the premise parameters and consequent parameters of the network. The proposed framework is tested and validated using synthetic and benchmark datasets suitable for MIL problems. Additionally, we apply the proposed Multiple Instance Inference to the problem of region-based image categorization as well as to fuse the output of multiple discrimination algorithms for the purpose of landmine detection using Ground Penetrating Radar

AdvMIL: Adversarial Multiple Instance Learning for the Survival Analysis on Whole-Slide Images

The survival analysis on histological whole-slide images (WSIs) is one of the most important means to estimate patient prognosis. Although many weakly-supervised deep learning models have been developed for gigapixel WSIs, their potential is generally restricted by classical survival analysis rules and fully-supervision requirements. As a result, these models provide patients only with a completely-certain point estimation of time-to-event, and they could only learn from the well-annotated WSI data currently at a small scale. To tackle these problems, we propose a novel adversarial multiple instance learning (AdvMIL) framework. This framework is based on adversarial time-to-event modeling, and it integrates the multiple instance learning (MIL) that is much necessary for WSI representation learning. It is a plug-and-play one, so that most existing WSI-based models with embedding-level MIL networks can be easily upgraded by applying this framework, gaining the improved ability of survival distribution estimation and semi-supervised learning. Our extensive experiments show that AdvMIL could not only bring performance improvement to mainstream WSI models at a relatively low computational cost, but also enable these models to learn from unlabeled data with semi-supervised learning. Our AdvMIL framework could promote the research of time-to-event modeling in computational pathology with its novel paradigm of adversarial MIL.Comment: 13 pages, 10 figures, 8 table

Rank discriminants for predicting phenotypes from RNA expression

Statistical methods for analyzing large-scale biomolecular data are commonplace in computational biology. A notable example is phenotype prediction from gene expression data, for instance, detecting human cancers, differentiating subtypes and predicting clinical outcomes. Still, clinical applications remain scarce. One reason is that the complexity of the decision rules that emerge from standard statistical learning impedes biological understanding, in particular, any mechanistic interpretation. Here we explore decision rules for binary classification utilizing only the ordering of expression among several genes; the basic building blocks are then two-gene expression comparisons. The simplest example, just one comparison, is the TSP classifier, which has appeared in a variety of cancer-related discovery studies. Decision rules based on multiple comparisons can better accommodate class heterogeneity, and thereby increase accuracy, and might provide a link with biological mechanism. We consider a general framework ("rank-in-context") for designing discriminant functions, including a data-driven selection of the number and identity of the genes in the support ("context"). We then specialize to two examples: voting among several pairs and comparing the median expression in two groups of genes. Comprehensive experiments assess accuracy relative to other, more complex, methods, and reinforce earlier observations that simple classifiers are competitive.Comment: Published in at http://dx.doi.org/10.1214/14-AOAS738 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Associative pattern mining for supervised learning

The Internet era has revolutionized computational sciences and automated data collection techniques, made large amounts of previously inaccessible data available and, consequently, broadened the scope of exploratory computing research. As a result, data mining, which is still an emerging field of research, has gained importance because of its ability to analyze and discover previously unknown, hidden, and useful knowledge from these large amounts of data. One aspect of data mining, known as frequent pattern mining, has recently gained importance due to its ability to find associative relationships among the parts of data, thereby aiding a type of supervised learning known as associative learning . The purpose of this dissertation is two-fold: to develop and demonstrate supervised associative learning in non-temporal data for multi-class classification and to develop a new frequent pattern mining algorithm for time varying (temporal) data which alleviates the current issues in analyzing this data for knowledge discovery. In order to use associative relationships for classification, we have to algorithmically learn their discriminatory power. While it is well known that multiple sets of features work better for classification, we claim that the isomorphic relationships among the features work even better and, therefore, can be used as higher order features. To validate this claim, we exploit these relationships as input features for classification instead of using the underlying raw features. The next part of this dissertation focuses on building a new classifier using associative relationships as a basis for the multi-class classification problem. Most of the existing associative classifiers represent the instances from a class in a row-based format wherein one row represents features of one instance and extract association rules from the entire dataset. The rules formed in this way are known as class constrained rules, as they have class labels on the right side of the rules. We argue that this class constrained representation schema lacks important information that is necessary for multi-class classification. Further, most existing works use either the intraclass or inter-class importance of the association rules, both of which sets of techniques offer empirical benefits. We hypothesize that both intra-class and inter-class variations are important for fast and accurate multi-class classification. We also present a novel weighted association rule-based classification mechanism that uses frequent relationships among raw features from an instance as the basis for classifying the instance into one of the many classes. The relationships are weighted according to both their intra-class and inter-class importance. The final part of this dissertation concentrates on mining time varying data. This problem is known as inter-transaction association rule mining in the data-mining field. Most of the existing work transforms the time varying data into a static format and then use multiple scans over the new data to extract patterns. We present a unique index-based algorithmic framework for inter-transaction association rule mining. Our proposed technique requires only one scan of the original database. Further, the proposed technique can also provide the location information of each extracted pattern. We use mathematical induction to prove that the new representation scheme captures all underlying frequent relationships

Learning and Interpreting Multi-Multi-Instance Learning Networks

We introduce an extension of the multi-instance learning problem where examples are organized as nested bags of instances (e.g., a document could be represented as a bag of sentences, which in turn are bags of words). This framework can be useful in various scenarios, such as text and image classification, but also supervised learning over graphs. As a further advantage, multi-multi instance learning enables a particular way of interpreting predictions and the decision function. Our approach is based on a special neural network layer, called bag-layer, whose units aggregate bags of inputs of arbitrary size. We prove theoretically that the associated class of functions contains all Boolean functions over sets of sets of instances and we provide empirical evidence that functions of this kind can be actually learned on semi-synthetic datasets. We finally present experiments on text classification, on citation graphs, and social graph data, which show that our model obtains competitive results with respect to accuracy when compared to other approaches such as convolutional networks on graphs, while at the same time it supports a general approach to interpret the learnt model, as well as explain individual predictions.Comment: JML

QCBA: Postoptimization of Quantitative Attributes in Classifiers based on Association Rules

The need to prediscretize numeric attributes before they can be used in association rule learning is a source of inefficiencies in the resulting classifier. This paper describes several new rule tuning steps aiming to recover information lost in the discretization of numeric (quantitative) attributes, and a new rule pruning strategy, which further reduces the size of the classification models. We demonstrate the effectiveness of the proposed methods on postoptimization of models generated by three state-of-the-art association rule classification algorithms: Classification based on Associations (Liu, 1998), Interpretable Decision Sets (Lakkaraju et al, 2016), and Scalable Bayesian Rule Lists (Yang, 2017). Benchmarks on 22 datasets from the UCI repository show that the postoptimized models are consistently smaller -- typically by about 50% -- and have better classification performance on most datasets

Language acquisition and machine learning

In this paper, we review recent progress in the field of machine learning and examine its implications for computational models of language acquisition. As a framework for understanding this research, we propose four component tasks involved in learning from experience - aggregation, clustering, characterization, and storage. We then consider four common problems studied by machine learning researchers - learning from examples, heuristics learning, conceptual clustering, and learning macro-operators - describing each in terms of our framework. After this, we turn to the problem of grammar acquisition, relating this problem to other learning tasks and reviewing four AI systems that have addressed the problem. Finally, we note some limitations of the earlier work and propose an alternative approach to modeling the mechanisms underlying language acquisition

Customer purchase behavior prediction in E-commerce: a conceptual framework and research agenda

Digital retailers are experiencing an increasing number of transactions coming from their consumers online, a consequence of the convenience in buying goods via E-commerce platforms. Such interactions compose complex behavioral patterns which can be analyzed through predictive analytics to enable businesses to understand consumer needs. In this abundance of big data and possible tools to analyze them, a systematic review of the literature is missing. Therefore, this paper presents a systematic literature review of recent research dealing with customer purchase prediction in the E-commerce context. The main contributions are a novel analytical framework and a research agenda in the field. The framework reveals three main tasks in this review, namely, the prediction of customer intents, buying sessions, and purchase decisions. Those are followed by their employed predictive methodologies and are analyzed from three perspectives. Finally, the research agenda provides major existing issues for further research in the field of purchase behavior prediction online