FPGA acceleration of DNA sequence alignment: design analysis and optimization

Existing FPGA accelerators for short read mapping often fail to utilize the complete biological information in sequencing data for simple hardware design, leading to missed or incorrect alignment. In this work, we propose a runtime reconfigurable alignment pipeline that considers all information in sequencing data for the biologically accurate acceleration of short read mapping. We focus our efforts on accelerating two string matching techniques: FM-index and the Smith-Waterman algorithm with the affine-gap model which are commonly used in short read mapping. We further optimize the FPGA hardware using a design analyzer and merger to improve alignment performance. The contributions of this work are as follows. 1. We accelerate the exact-match and mismatch alignment by leveraging the FM-index technique. We optimize memory access by compressing the data structure and interleaving the access with multiple short reads. The FM-index hardware also considers complete information in the read data to maximize accuracy. 2. We propose a seed-and-extend model to accelerate alignment with indels. The FM-index hardware is extended to support the seeding stage while a Smith-Waterman implementation with the affine-gap model is developed on FPGA for the extension stage. This model can improve the efficiency of indel alignment with comparable accuracy versus state-of-the-art software. 3. We present an approach for merging multiple FPGA designs into a single hardware design, so that multiple place-and-route tasks can be replaced by a single task to speed up functional evaluation of designs. We first experiment with this approach to demonstrate its feasibility for different designs. Then we apply this approach to optimize one of the proposed FPGA aligners for better alignment performance.Open Acces

FOS: A Modular FPGA Operating System for Dynamic Workloads

With FPGAs now being deployed in the cloud and at the edge, there is a need for scalable design methods which can incorporate the heterogeneity present in the hardware and software components of FPGA systems. Moreover, these FPGA systems need to be maintainable and adaptable to changing workloads while improving accessibility for the application developers. However, current FPGA systems fail to achieve modularity and support for multi-tenancy due to dependencies between system components and lack of standardised abstraction layers. To solve this, we introduce a modular FPGA operating system -- FOS, which adopts a modular FPGA development flow to allow each system component to be changed and be agnostic to the heterogeneity of EDA tool versions, hardware and software layers. Further, to dynamically maximise the utilisation transparently from the users, FOS employs resource-elastic scheduling to arbitrate the FPGA resources in both time and spatial domain for any type of accelerators. Our evaluation on different FPGA boards shows that FOS can provide performance improvements in both single-tenant and multi-tenant environments while substantially reducing the development time and, at the same time, improving flexibility

MURAC: A unified machine model for heterogeneous computers

Includes bibliographical referencesHeterogeneous computing enables the performance and energy advantages of multiple distinct processing architectures to be efficiently exploited within a single machine. These systems are capable of delivering large performance increases by matching the applications to architectures that are most suited to them. The Multiple Runtime-reconfigurable Architecture Computer (MURAC) model has been proposed to tackle the problems commonly found in the design and usage of these machines. This model presents a system-level approach that creates a clear separation of concerns between the system implementer and the application developer. The three key concepts that make up the MURAC model are a unified machine model, a unified instruction stream and a unified memory space. A simple programming model built upon these abstractions provides a consistent interface for interacting with the underlying machine to the user application. This programming model simplifies application partitioning between hardware and software and allows the easy integration of different execution models within the single control ow of a mixed-architecture application. The theoretical and practical trade-offs of the proposed model have been explored through the design of several systems. An instruction-accurate system simulator has been developed that supports the simulated execution of mixed-architecture applications. An embedded System-on-Chip implementation has been used to measure the overhead in hardware resources required to support the model, which was found to be minimal. An implementation of the model within an operating system on a tightly-coupled reconfigurable processor platform has been created. This implementation is used to extend the software scheduler to allow for the full support of mixed-architecture applications in a multitasking environment. Different scheduling strategies have been tested using this scheduler for mixed-architecture applications. The design and implementation of these systems has shown that a unified abstraction model for heterogeneous computers provides important usability benefits to system and application designers. These benefits are achieved through a consistent view of the multiple different architectures to the operating system and user applications. This allows them to focus on achieving their performance and efficiency goals by gaining the benefits of different execution models during runtime without the complex implementation details of the system-level synchronisation and coordination

From MARTE to dynamically reconfigurable FPGAs : Introduction of a control extension in a model based design flow

System-on-Chip (SoC) can be considered as a particular case of embedded systems and has rapidly became a de-facto solution for implement- ing these complex systems. However, due to the continuous exponential rise in SoC's design complexity, there is a critical need to find new seamless method- ologies and tools to handle the SoC co-design aspects. This paper addresses this issue and proposes a novel SoC co-design methodology based on Model Driven Engineering (MDE) and the MARTE (Modeling and Analysis of Real-Time and Embedded Systems) standard proposed by OMG (Object Management Group), in order to raise the design abstraction levels. Extensions of this standard have enabled us to move from high level specifications to execution platforms such as reconfigurable FPGAs; and allow to implement the notion of Partial Dy- namic Reconfiguration supported by current FPGAs. The overall objective is to carry out system modeling at a high abstraction level expressed in UML (Unified Modeling Language); and afterwards, transform these high level mod- els into detailed enriched lower level models in order to automatically generate the necessary code for final FPGA synthesis

FPGA structures for high speed and low overhead dynamic circuit specialization

A Field Programmable Gate Array (FPGA) is a programmable digital electronic chip. The FPGA does not come with a predefined function from the manufacturer; instead, the developer has to define its function through implementing a digital circuit on the FPGA resources. The functionality of the FPGA can be reprogrammed as desired and hence the name “field programmable”. FPGAs are useful in small volume digital electronic products as the design of a digital custom chip is expensive. Changing the FPGA (also called configuring it) is done by changing the configuration data (in the form of bitstreams) that defines the FPGA functionality. These bitstreams are stored in a memory of the FPGA called configuration memory. The SRAM cells of LookUp Tables (LUTs), Block Random Access Memories (BRAMs) and DSP blocks together form the configuration memory of an FPGA. The configuration data can be modified according to the user’s needs to implement the user-defined hardware. The simplest way to program the configuration memory is to download the bitstreams using a JTAG interface. However, modern techniques such as Partial Reconfiguration (PR) enable us to configure a part in the configuration memory with partial bitstreams during run-time. The reconfiguration is achieved by swapping in partial bitstreams into the configuration memory via a configuration interface called Internal Configuration Access Port (ICAP). The ICAP is a hardware primitive (macro) present in the FPGA used to access the configuration memory internally by an embedded processor. The reconfiguration technique adds flexibility to use specialized ci rcuits that are more compact and more efficient t han t heir b ulky c ounterparts. An example of such an implementation is the use of specialized multipliers instead of big generic multipliers in an FIR implementation with constant coefficients. To specialize these circuits and reconfigure during the run-time, researchers at the HES group proposed the novel technique called parameterized reconfiguration that can be used to efficiently and automatically implement Dynamic Circuit Specialization (DCS) that is built on top of the Partial Reconfiguration method. It uses the run-time reconfiguration technique that is tailored to implement a parameterized design. An application is said to be parameterized if some of its input values change much less frequently than the rest. These inputs are called parameters. Instead of implementing these parameters as regular inputs, in DCS these inputs are implemented as constants, and the application is optimized for the constants. For every change in parameter values, the design is re-optimized (specialized) during run-time and implemented by reconfiguring the optimized design for a new set of parameters. In DCS, the bitstreams of the parameterized design are expressed as Boolean functions of the parameters. For every infrequent change in parameters, a specialized FPGA configuration is generated by evaluating the corresponding Boolean functions, and the FPGA is reconfigured with the specialized configuration. A detailed study of overheads of DCS and providing suitable solutions with appropriate custom FPGA structures is the primary goal of the dissertation. I also suggest different improvements to the FPGA configuration memory architecture. After offering the custom FPGA structures, I investigated the role of DCS on FPGA overlays and the use of custom FPGA structures that help to reduce the overheads of DCS on FPGA overlays. By doing so, I hope I can convince the developer to use DCS (which now comes with minimal costs) in real-world applications. I start the investigations of overheads of DCS by implementing an adaptive FIR filter (using the DCS technique) on three different Xilinx FPGA platforms: Virtex-II Pro, Virtex-5, and Zynq-SoC. The study of how DCS behaves and what is its overhead in the evolution of the three FPGA platforms is the non-trivial basis to discover the costs of DCS. After that, I propose custom FPGA structures (reconfiguration controllers and reconfiguration drivers) to reduce the main overhead (reconfiguration time) of DCS. These structures not only reduce the reconfiguration time but also help curbing the power hungry part of the DCS system. After these chapters, I study the role of DCS on FPGA overlays. I investigate the effect of the proposed FPGA structures on Virtual-Coarse-Grained Reconfigurable Arrays (VCGRAs). I classify the VCGRA implementations into three types: the conventional VCGRA, partially parameterized VCGRA and fully parameterized VCGRA depending upon the level of parameterization. I have designed two variants of VCGRA grids for HPC image processing applications, namely, the MAC grid and Pixie. Finally, I try to tackle the reconfiguration time overhead at the hardware level of the FPGA by customizing the FPGA configuration memory architecture. In this part of my research, I propose to use a parallel memory structure to improve the reconfiguration time of DCS drastically. However, this improvement comes with a significant overhead of hardware resources which will need to be solved in future research on commercial FPGA configuration memory architectures