278,379 research outputs found
Multi-user Linear Precoding for Multi-polarized Massive MIMO System under Imperfect CSIT
The space limitation and the channel acquisition prevent Massive MIMO from
being easily deployed in a practical setup. Motivated by current deployments of
LTE-Advanced, the use of multi-polarized antennas can be an efficient solution
to address the space constraint. Furthermore, the dual-structured precoding, in
which a preprocessing based on the spatial correlation and a subsequent linear
precoding based on the short-term channel state information at the transmitter
(CSIT) are concatenated, can reduce the feedback overhead efficiently. By
grouping and preprocessing spatially correlated mobile stations (MSs), the
dimension of the precoding signal space is reduced and the corresponding
short-term CSIT dimension is reduced. In this paper, to reduce the feedback
overhead further, we propose a dual-structured multi-user linear precoding, in
which the subgrouping method based on co-polarization is additionally applied
to the spatially grouped MSs in the preprocessing stage. Furthermore, under
imperfect CSIT, the proposed scheme is asymptotically analyzed based on random
matrix theory. By investigating the behavior of the asymptotic performance, we
also propose a new dual-structured precoding in which the precoding mode is
switched between two dual-structured precoding strategies with 1) the
preprocessing based only on the spatial correlation and 2) the preprocessing
based on both the spatial correlation and polarization. Finally, we extend it
to 3D dual-structured precoding.Comment: accepted to IEEE Transactions on Wireless Communication
Without magic bullets: the biological basis for public health interventions against protein folding disorders
Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter disease course. The design of individual or population level interventions will likely require a deeper understanding of protein folding and its regulation than currently provided by contemporary 'physics' or culture-bound medical magic bullet models. Here, a topological rate distortion analysis is applied to the problem of protein folding and regulation that is similar in spirit to Tlusty's (2010a) elegant exploration of the genetic code. The formalism produces large-scale, quasi-equilibrium 'resilience' states representing normal and pathological protein folding regulation under a cellular-level cognitive paradigm similar to that proposed by Atlan and Cohen (1998) for the immune system. Generalization to long times produces diffusion models of protein folding disorders in which epigenetic or life history factors determine the rate of onset of regulatory failure, in essence, a premature aging driven by familiar synergisms between disjunctions of resource allocation and need in the context of socially or physiologically toxic exposures and chronic powerlessness at individual and group scales. Application of an HPA axis model is made to recent observed differences in Alzheimer's onset rates in White and African American subpopulations as a function of an index of distress-proneness
The cultural epigenetics of psychopathology: The missing heritability of complex diseases found?
We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders. In particular, we recognize the fundamental role culture plays in human biology, another heritage mechanism parallel to, and interacting with, the more familiar genetic and epigenetic systems. We do this via a model through which culture acts as another tunable epigenetic catalyst that both directs developmental trajectories, and becomes convoluted with individual ontology, via a mutually-interacting crosstalk mediated by a social interaction that is itself culturally driven. We call for the incorporation of embedding culture as an essential component of the epigenetic regulation of human mental development and its dysfunctions, bringing what is perhaps the central reality of human biology into the center of biological psychiatry. Current US work on gene-environment interactions in psychiatry must be extended to a model of gene-environment-culture interaction to avoid becoming victim of an extreme American individualism that threatens to create paradigms particular to that culture and that are, indeed, peculiar in the context of the world's cultures. The cultural and epigenetic systems of heritage may well provide the 'missing' heritability of complex diseases now under so much intense discussion
Applying semantic web technologies to knowledge sharing in aerospace engineering
This paper details an integrated methodology to optimise Knowledge reuse and sharing, illustrated with a use case in the aeronautics domain. It uses Ontologies as a central modelling strategy for the Capture of Knowledge from legacy docu-ments via automated means, or directly in systems interfacing with Knowledge workers, via user-defined, web-based forms. The domain ontologies used for Knowledge Capture also guide the retrieval of the Knowledge extracted from the data using a Semantic Search System that provides support for multiple modalities during search. This approach has been applied and evaluated successfully within the aerospace domain, and is currently being extended for use in other domains on an increasingly large scale
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