Development of a sub-miniature acoustic sensor for wireless monitoring of heart rate

This thesis presents the development of a non-invasive, wireless, low-power, phonocardiographic (PCG) or heart sound sensor platform suitable for long-term monitoring of heart function. The core of this development process involves a study of the feasibility of this conceptual system and the development of a prototype mixed-signals integrated circuit (IC) to form the integral component of the proposed sensor. The feasibility study of the proposed long-term monitoring sensor is divided into two main parts. The first part of the study investigates the technological aspect of the conceptual system, via a system level design. This is to prove the technological or operational feasibility of the system, where the system can be built completely using discrete, off-the-shelf electronics components to satisfy the size, power consumption, battery life and operational requirements of the sensor platform. The second part of the study concentrates on the post-processing of the heart sounds and murmurs or PCG data recorded. This is where a number of different de-noising algorithms are studied and their relative performance compared when applied to a variety of different noisy heart sound signals that would likely be acquired using the proposed sensor in everyday life. This was done to demonstrate the functional feasibility of the proposed system, where the ambient acoustic noise in the recorded PCG data can be effectively suppressed and therefore meaningful analysis of heart function i.e. heart rate, can be performed on the data. After the feasibility of the conceptual system has been demonstrated, the final part of this thesis discusses the synthesis and testing of a 0.35 μm CMOS technology prototype mixed analog-digital integrated circuit (IC) to miniaturise part of this sensor platform outlined in the system level design, conducted in the earlier part of this thesis, to achieve the objective specifications – in terms of the size and power consumption. A new implementation of the multi-tanh triplet transconductor is introduced to construct a pair of 100 nW analogue 4th order Gm-C signal conditioning filters. Furthermore, a 7 μW digital circuit was designed to drive the analog-to-digital conversion cycle of the Linear Technology LTC1288 ADC and synchronise the ADC’s output to generate the Manchester encoded data compatible with the Holt Integrated Circuit HI-15530 Manchester Encoder/Decoder

Low-Power and Programmable Analog Circuitry for Wireless Sensors

Embedding networks of secure, wirelessly-connected sensors and actuators will help us to conscientiously manage our local and extended environments. One major challenge for this vision is to create networks of wireless sensor devices that provide maximal knowledge of their environment while using only the energy that is available within that environment. In this work, it is argued that the energy constraints in wireless sensor design are best addressed by incorporating analog signal processors. The low power-consumption of an analog signal processor allows persistent monitoring of multiple sensors while the device\u27s analog-to-digital converter, microcontroller, and transceiver are all in sleep mode. This dissertation describes the development of analog signal processing integrated circuits for wireless sensor networks. Specific technology problems that are addressed include reconfigurable processing architectures for low-power sensing applications, as well as the development of reprogrammable biasing for analog circuits

Ultra-low-power circuits and systems for wearable and implantable medical devices

Thesis (Ph. D.)--Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 219-231).Advances in circuits, sensors, and energy storage elements have opened up many new possibilities in the health industry. In the area of wearable devices, the miniaturization of electronics has spurred the rapid development of wearable vital signs, activity, and fitness monitors. Maximizing the time between battery recharge places stringent requirements on power consumption by the device. For implantable devices, the situation is exacerbated by the fact that energy storage capacity is limited by volume constraints, and frequent battery replacement via surgery is undesirable. In this case, the design of energy-efficient circuits and systems becomes even more crucial. This thesis explores the design of energy-efficient circuits and systems for two medical applications. The first half of the thesis focuses on the design and implementation of an ultra-low-power, mixed-signal front-end for a wearable ECG monitor in a 0.18pm CMOS process. A mixed-signal architecture together with analog circuit optimizations enable ultra-low-voltage operation at 0.6V which provides power savings through voltage scaling, and ensures compatibility with state-of-the-art DSPs. The fully-integrated front-end consumes just 2.9[mu]W, which is two orders of magnitude lower than commercially available parts. The second half of this thesis focuses on ultra-low-power system design and energy-efficient neural stimulation for a proof-of-concept fully-implantable cochlear implant. First, implantable acoustic sensing is demonstrated by sensing the motion of a human cadaveric middle ear with a piezoelectric sensor. Second, alternate energy-efficient electrical stimulation waveforms are investigated to reduce neural stimulation power when compared to the conventional rectangular waveform. The energy-optimal waveform is analyzed using a computational nerve fiber model, and validated with in-vivo ECAP recordings in the auditory nerve of two cats and with psychophysical tests in two human cochlear implant users. Preliminary human subject testing shows that charge and energy savings of 20-30% and 15-35% respectively are possible with alternative waveforms. A system-on-chip comprising the sensor interface, reconfigurable sound processor, and arbitrary-waveform neural stimulator is implemented in a 0.18[mu]m high-voltage CMOS process to demonstrate the feasibility of this system. The sensor interface and sound processor consume just 12[mu]W of power, representing just 2% of the overall system power which is dominated by stimulation. As a result, the energy savings from using alternative stimulation waveforms transfer directly to the system.by Marcus Yip.Ph.D

Multimodal Wearable Sensors for Human-Machine Interfaces

Certain areas of the body, such as the hands, eyes and organs of speech production, provide high-bandwidth information channels from the conscious mind to the outside world. The objective of this research was to develop an innovative wearable sensor device that records signals from these areas more conveniently than has previously been possible, so that they can be harnessed for communication. A novel bioelectrical and biomechanical sensing device, the wearable endogenous biosignal sensor (WEBS), was developed and tested in various communication and clinical measurement applications. One ground-breaking feature of the WEBS system is that it digitises biopotentials almost at the point of measurement. Its electrode connects directly to a high-resolution analog-to-digital converter. A second major advance is that, unlike previous active biopotential electrodes, the WEBS electrode connects to a shared data bus, allowing a large or small number of them to work together with relatively few physical interconnections. Another unique feature is its ability to switch dynamically between recording and signal source modes. An accelerometer within the device captures real-time information about its physical movement, not only facilitating the measurement of biomechanical signals of interest, but also allowing motion artefacts in the bioelectrical signal to be detected. Each of these innovative features has potentially far-reaching implications in biopotential measurement, both in clinical recording and in other applications. Weighing under 0.45 g and being remarkably low-cost, the WEBS is ideally suited for integration into disposable electrodes. Several such devices can be combined to form an inexpensive digital body sensor network, with shorter set-up time than conventional equipment, more flexible topology, and fewer physical interconnections. One phase of this study evaluated areas of the body as communication channels. The throat was selected for detailed study since it yields a range of voluntarily controllable signals, including laryngeal vibrations and gross movements associated with vocal tract articulation. A WEBS device recorded these signals and several novel methods of human-to-machine communication were demonstrated. To evaluate the performance of the WEBS system, recordings were validated against a high-end biopotential recording system for a number of biopotential signal types. To demonstrate an application for use by a clinician, the WEBS system was used to record 12‑lead electrocardiogram with augmented mechanical movement information