A database system with amnesia

Big Data comes with huge challenges. Its volume and velocity makes handling, curating, and analytical processing a costly affair. Even to simply “look at” the data within an a priori defined budget and with a guaranteed interactive response time might be impossible to achieve. Commonly applied scale-out approaches will hit the technology and monetary wall soon, if not done so already. Likewise, blindly rejecting data when the channels are full, or reducing the data resolution at the source, might lead to loss of valuable observations. An army of well-educated database administrators or full software stack architects might deal with these challenges albeit at substantial cost. This calls for a mostly knobless DBMS with a fundamental change in database management. Data rotting has been proposed as a direction to find a solution [10, 11]. For the sake of storage management and responsiveness, it lets the DBMS semi-autonomously rot away data. Rotting is based on the systems own unwillingness to keep old data as easily accessible as fresh data. This paper sheds more light on the opportunities and potential impacts of this radical departure in data management. Specifically, we study the case where a DBMS selectively forgets tuples (by marking them inactive) under various amnesia scenarios and with different implementation strategies. Our ultimate goal is to use the findings of this study to morph an existing data management engine to serve demanding big data scientific applications with well-chosen built-in data a

Normal and Amnesic Learning, Recognition, and Memory by a Neural Model of Cortico-Hippocampal Interactions

The processes by which humans and other primates learn to recognize objects have been the subject of many models. Processes such as learning, categorization, attention, memory search, expectation, and novelty detection work together at different stages to realize object recognition. In this article, Gail Carpenter and Stephen Grossberg describe one such model class (Adaptive Resonance Theory, ART) and discuss how its structure and function might relate to known neurological learning and memory processes, such as how inferotemporal cortex can recognize both specialized and abstract information, and how medial temporal amnesia may be caused by lesions in the hippocampal formation. The model also suggests how hippocampal and inferotemporal processing may be linked during recognition learning.Air Force Office of Scientific Research (90-0175); British Petroleum (89A-1204); Defense Advanced Research Projects Agency (90-0083); National Science Foundation (IRI-90-00530); Office of Naval Research (N00014-91-J-4100

Reverse Proxy Framework using Sanitization Technique for Intrusion Prevention in Database

With the increasing importance of the internet in our day to day life, data security in web application has become very crucial. Ever increasing on line and real time transaction services have led to manifold rise in the problems associated with the database security. Attacker uses illegal and unauthorized approaches to hijack the confidential information like username, password and other vital details. Hence the real time transaction requires security against web based attacks. SQL injection and cross site scripting attack are the most common application layer attack. The SQL injection attacker pass SQL statement through a web applications input fields, URL or hidden parameters and get access to the database or update it. The attacker take a benefit from user provided data in such a way that the users input is handled as a SQL code. Using this vulnerability an attacker can execute SQL commands directly on the database. SQL injection attacks are most serious threats which take users input and integrate it into SQL query. Reverse Proxy is a technique which is used to sanitize the users inputs that may transform into a database attack. In this technique a data redirector program redirects the users input to the proxy server before it is sent to the application server. At the proxy server, data cleaning algorithm is triggered using a sanitizing application. In this framework we include detection and sanitization of the tainted information being sent to the database and innovate a new prototype.Comment: 9 pages, 6 figures, 3 tables; CIIT 2013 International Conference, Mumba

Historical Amnesia: British and U.S. Intelligence, Past and Present

Many intelligence scandals in the news today seem unprecedented - from Russian meddling in the 2016 U.S. Presidential election, to British and U.S. intelligence agencies monitoring activities of their citizens. They seem new largely because, traditionally, intelligence agencies on both sides of the Atlantic were excessively secretive about their past activities: even the names “GCHQ” and “NSA” were airbrushed from declassified records, and thus missing from major historical works and scholarship on on post-war international relations. The resulting secrecy about British and U.S. intelligence has led to misunderstandings and conspiracy theories in societies about them. Newly opened secret records now reveal the long history of many subjects seen in today’s news-cycle: Anglo-American intelligence cooperation, interference by countries in foreign elections, disinformation, and the use and abuse of intelligence by governments. Newly declassified records also add to our understanding of major chapters of international history, like Britain’s post-war end of empire. Without overcoming our historical amnesia disorder about U.S. and British intelligence, citizens, scholars and policy-makers cannot hope to understand the proper context for what secret agencies are doing today

Preventing SQL Injection through Automatic Query Sanitization with ASSIST

Web applications are becoming an essential part of our everyday lives. Many of our activities are dependent on the functionality and security of these applications. As the scale of these applications grows, injection vulnerabilities such as SQL injection are major security challenges for developers today. This paper presents the technique of automatic query sanitization to automatically remove SQL injection vulnerabilities in code. In our technique, a combination of static analysis and program transformation are used to automatically instrument web applications with sanitization code. We have implemented this technique in a tool named ASSIST (Automatic and Static SQL Injection Sanitization Tool) for protecting Java-based web applications. Our experimental evaluation showed that our technique is effective against SQL injection vulnerabilities and has a low overhead.Comment: In Proceedings TAV-WEB 2010, arXiv:1009.330

Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory.

Proton-pump inhibitors, PPIs, are considered effective therapy for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump in the gastric parietal cells. They are widely prescribed and are considered safe for over-the-counter use. Recent studies have shown an association between PPI use and Alzheimer dementia, while others have disputed that connection. We analyzed over ten million United States Food and Drug Administration Adverse Event Reporting System reports, including over forty thousand reports containing PPIs, and provided evidence of increased propensity for memory impairment among PPI reports when compared to histamine-2 receptor antagonist control group. Furthermore, we found significant associations of PPI use with a wide range of neurological adverse reactions including, migraine, several peripheral neuropathies, and visual and auditory neurosensory abnormalities

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes

Intravitreal Anti-VEGF Drugs and Signals of Dementia and Parkinson-Like Events: Analysis of the VigiBase Database of Spontaneous Reports

Introduction: Since vascular endothelial growth factor (VEGF) regulates several aspects of the central nervous system, particularly in dopaminergic neurons, VEGF inhibitors may be linked to Parkinson-like events and dementia, or variants of these diseases. Two recent case reports have found a potential link between intravitreal anti-VEGF use and Parkinson’s disease (PD) and dementia. Aim: To evaluate disproportionality in a large spontaneous reporting database concerning intravitreal anti-VEGF drugs and PD or dementia, and related conditions. Methods: Using VigiBase, individual case safety reports (ICSRs) attributed to intravitreal ranibizumab, aflibercept, pegaptanib, and bevacizumab were identified from 2010 to 2016. Within Standardised Narrow Medical Dictionary for Regulatory Activities (MedDRA®) Queries (SMQs) for “Parkinson-like events” and “Dementia,” suspected events were identified using preferred terms (PTs). The Proportional Reporting Ratio (PRR) was estimated with the lower 95% confidence intervals (CIs) for all drug-event pairs with ≥3 suspected events. The vigiGrade completeness score was reported for the ICSRs. The analyses were repeated, including only persons aged 65 and over. Results: Out of 18.9 million ICSRs, 7,945 (0.004%) concerned intravitreal anti-VEGF drugs. Of these, 27 (0.34%) were identified concerning the SMQs “Dementia” (N = 17, 62.96%) and “Parkinson-like events” (N = 10, 37.94%) in persons of all ages. Among persons age 65 and over, 4,758 (59.88% of relevant ICSRs) ICSRs were identified for anti-VEGF drugs. When restricting disproportionality analysis to persons aged 65 and over, no disproportionality was seen for any of the drug-event pairs at the level of SMQ. However, on analysing disproportionality by PT, a potential signal emerged for intravitreal ranibizumab and Parkinson’s disease [N = 6 ICSRs; PRR: 3.05 (95% CI: 1.36-6.81)]. In general, the vigiGrade completeness score was low for all the ICSRs of interest, as no ICSR had a score >0.8. Conclusion: Present findings suggest a potential signal for Parkinson’s disease related to intravitreal ranibizumab. This is supported by several biologically plausible mechanisms but requires confirmation through pharmacoepidemiological studies, especially because of the low number of cases