14,681 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Performance Analysis and Optimization of Sparse Matrix-Vector Multiplication on Modern Multi- and Many-Core Processors
This paper presents a low-overhead optimizer for the ubiquitous sparse
matrix-vector multiplication (SpMV) kernel. Architectural diversity among
different processors together with structural diversity among different sparse
matrices lead to bottleneck diversity. This justifies an SpMV optimizer that is
both matrix- and architecture-adaptive through runtime specialization. To this
direction, we present an approach that first identifies the performance
bottlenecks of SpMV for a given sparse matrix on the target platform either
through profiling or by matrix property inspection, and then selects suitable
optimizations to tackle those bottlenecks. Our optimization pool is based on
the widely used Compressed Sparse Row (CSR) sparse matrix storage format and
has low preprocessing overheads, making our overall approach practical even in
cases where fast decision making and optimization setup is required. We
evaluate our optimizer on three x86-based computing platforms and demonstrate
that it is able to distinguish and appropriately optimize SpMV for the majority
of matrices in a representative test suite, leading to significant speedups
over the CSR and Inspector-Executor CSR SpMV kernels available in the latest
release of the Intel MKL library.Comment: 10 pages, 7 figures, ICPP 201
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