Integration of Biological Sources: Exploring the Case of Protein Homology

Data integration is a key issue in the domain of bioin- formatics, which deals with huge amounts of heteroge- neous biological data that grows and changes rapidly. This paper serves as an introduction in the field of bioinformatics and the biological concepts it deals with, and an exploration of the integration problems a bioinformatics scientist faces. We examine ProGMap, an integrated protein homology system used by bioin- formatics scientists at Wageningen University, and several use cases related to protein homology. A key issue we identify is the huge manual effort required to unify source databases into a single resource. Un- certain databases are able to contain several possi- ble worlds, and it has been proposed that they can be used to significantly reduce initial integration efforts. We propose several directions for future work where uncertain databases can be applied to bioinformatics, with the goal of furthering the cause of bioinformatics integration

Improved data retrieval from TreeBASE via taxonomic and linguistic data enrichment

Background: TreeBASE, the only data repository for phylogenetic studies, is not being used effectively since it does not meet the taxonomic data retrieval requirements of the systematics community. We show, through an examination of the queries performed on TreeBASE, that data retrieval using taxon names is unsatisfactory. Results: We report on a new wrapper supporting taxon queries on TreeBASE by utilising a Taxonomy and Classification Database (TCl-Db) we created. TCl-Db holds merged and consolidated taxonomic names from multiple data sources and can be used to translate hierarchical, vernacular and synonym queries into specific query terms in TreeBASE. The query expansion supported by TCl-Db shows very significant information retrieval quality improvement. The wrapper can be accessed at the URL http://spira.zoology.gla.ac.uk/app/tbasewrapper.php The methodology we developed is scalable and can be applied to new data, as those become available in the future. Conclusion: Significantly improved data retrieval quality is shown for all queries, and additional flexibility is achieved via user-driven taxonomy selection

The Knowledge Level Approach To Intelligent Information System Design

Traditional approaches to building intelligent information systems employ an ontology to define a representational structure for the data and information of interest within the target domain of the system. At runtime, the ontology provides a constrained template for the creation of the individual objects and relationships that together define the state of the system at a given point in time. The ontology also provides a vocabulary for expressing domain knowledge typically in the form of rules (declarative knowledge) or methods (procedural knowledge). The system utilizes the encoded knowledge, often in conjunction user input, to progress the state of the system towards the specific goals indicated by the users. While this approach has been very successful, it has some drawbacks. Regardless of the implementation paradigm the knowledge is essentially buried in the code and therefore inaccessible to most domain experts. The knowledge also tends to be very domain specific and is not extensible at runtime. This paper describes a variation on the traditional approach that employs an explicit knowledge level within the ontology to mitigate the identified drawbacks

Survey over Existing Query and Transformation Languages

A widely acknowledged obstacle for realizing the vision of the Semantic Web is the inability of many current Semantic Web approaches to cope with data available in such diverging representation formalisms as XML, RDF, or Topic Maps. A common query language is the first step to allow transparent access to data in any of these formats. To further the understanding of the requirements and approaches proposed for query languages in the conventional as well as the Semantic Web, this report surveys a large number of query languages for accessing XML, RDF, or Topic Maps. This is the first systematic survey to consider query languages from all these areas. From the detailed survey of these query languages, a common classification scheme is derived that is useful for understanding and differentiating languages within and among all three areas