A Comprehensive Overview of Computational Nuclei Segmentation Methods in Digital Pathology

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in appearance, sourcing either from the acquisition devices or the H\&E staining process. Nuclei segmentation is an important task, as it detects the nuclei cells over background tissue and gives rise to the topology, size, and count of nuclei which are determinant factors for cancer detection. Yet, it is a fairly time consuming task for pathologists, with reportedly high subjectivity. Computer Aided Diagnosis (CAD) tools empowered by modern Artificial Intelligence (AI) models enable the automation of nuclei segmentation. This can reduce the subjectivity in analysis and reading time. This paper provides an extensive review, beginning from earlier works use traditional image processing techniques and reaching up to modern approaches following the Deep Learning (DL) paradigm. Our review also focuses on the weak supervision aspect of the problem, motivated by the fact that annotated data is scarce. At the end, the advantages of different models and types of supervision are thoroughly discussed. Furthermore, we try to extrapolate and envision how future research lines will potentially be, so as to minimize the need for labeled data while maintaining high performance. Future methods should emphasize efficient and explainable models with a transparent underlying process so that physicians can trust their output.Comment: 47 pages, 27 figures, 9 table

Towards Geometric Understanding of Motion

The motion of the world is inherently dependent on the spatial structure of the world and its geometry. Therefore, classical optical flow methods try to model this geometry to solve for the motion. However, recent deep learning methods take a completely different approach. They try to predict optical flow by learning from labelled data. Although deep networks have shown state-of-the-art performance on classification problems in computer vision, they have not been as effective in solving optical flow. The key reason is that deep learning methods do not explicitly model the structure of the world in a neural network, and instead expect the network to learn about the structure from data. We hypothesize that it is difficult for a network to learn about motion without any constraint on the structure of the world. Therefore, we explore several approaches to explicitly model the geometry of the world and its spatial structure in deep neural networks. The spatial structure in images can be captured by representing it at multiple scales. To represent multiple scales of images in deep neural nets, we introduce a Spatial Pyramid Network (SpyNet). Such a network can leverage global information for estimating large motions and local information for estimating small motions. We show that SpyNet significantly improves over previous optical flow networks while also being the smallest and fastest neural network for motion estimation. SPyNet achieves a 97% reduction in model parameters over previous methods and is more accurate. The spatial structure of the world extends to people and their motion. Humans have a very well-defined structure, and this information is useful in estimating optical flow for humans. To leverage this information, we create a synthetic dataset for human optical flow using a statistical human body model and motion capture sequences. We use this dataset to train deep networks and see significant improvement in the ability of the networks to estimate human optical flow. The structure and geometry of the world affects the motion. Therefore, learning about the structure of the scene together with the motion can benefit both problems. To facilitate this, we introduce Competitive Collaboration, where several neural networks are constrained by geometry and can jointly learn about structure and motion in the scene without any labels. To this end, we show that jointly learning single view depth prediction, camera motion, optical flow and motion segmentation using Competitive Collaboration achieves state-of-the-art results among unsupervised approaches. Our findings provide support for our hypothesis that explicit constraints on structure and geometry of the world lead to better methods for motion estimation