8,528 research outputs found
In vivo measurement of human brain elasticity using a light aspiration device
The brain deformation that occurs during neurosurgery is a serious issue
impacting the patient "safety" as well as the invasiveness of the brain
surgery. Model-driven compensation is a realistic and efficient solution to
solve this problem. However, a vital issue is the lack of reliable and easily
obtainable patient-specific mechanical characteristics of the brain which,
according to clinicians' experience, can vary considerably. We designed an
aspiration device that is able to meet the very rigorous sterilization and
handling process imposed during surgery, and especially neurosurgery. The
device, which has no electronic component, is simple, light and can be
considered as an ancillary instrument. The deformation of the aspirated tissue
is imaged via a mirror using an external camera. This paper describes the
experimental setup as well as its use during a specific neurosurgery. The
experimental data was used to calibrate a continuous model. We show that we
were able to extract an in vivo constitutive law of the brain elasticity: thus
for the first time, measurements are carried out per-operatively on the
patient, just before the resection of the brain parenchyma. This paper
discloses the results of a difficult experiment and provide for the first time
in-vivo data on human brain elasticity. The results point out the softness as
well as the highly non-linear behavior of the brain tissue.Comment: Medical Image Analysis (2009) accept\'
Registration of brain tumor images using hyper-elastic regularization
In this paper, we present a method to estimate a deformation
field between two instances of a brain volume having tumor. The novelties
include the assessment of the disease progress by observing the healthy tissue
deformation and usage of the Neo-Hookean strain energy density model as
a regularizer in deformable registration framework. Implementations on synthetic
and patient data provide promising results, which might have relevant
use in clinical problems
Framework for a low-cost intra-operative image-guided neuronavigator including brain shift compensation
In this paper we present a methodology to address the problem of brain tissue
deformation referred to as 'brain-shift'. This deformation occurs throughout a
neurosurgery intervention and strongly alters the accuracy of the
neuronavigation systems used to date in clinical routine which rely solely on
pre-operative patient imaging to locate the surgical target, such as a tumour
or a functional area. After a general description of the framework of our
intra-operative image-guided system, we describe a procedure to generate
patient specific finite element meshes of the brain and propose a biomechanical
model which can take into account tissue deformations and surgical procedures
that modify the brain structure, like tumour or tissue resection
Phenomenological model of diffuse global and regional atrophy using finite-element methods
The main goal of this work is the generation of ground-truth data for the validation of atrophy measurement techniques, commonly used in the study of neurodegenerative diseases such as dementia. Several techniques have been used to measure atrophy in cross-sectional and longitudinal studies, but it is extremely difficult to compare their performance since they have been applied to different patient populations. Furthermore, assessment of performance based on phantom measurements or simple scaled images overestimates these techniques' ability to capture the complexity of neurodegeneration of the human brain. We propose a method for atrophy simulation in structural magnetic resonance (MR) images based on finite-element methods. The method produces cohorts of brain images with known change that is physically and clinically plausible, providing data for objective evaluation of atrophy measurement techniques. Atrophy is simulated in different tissue compartments or in different neuroanatomical structures with a phenomenological model. This model of diffuse global and regional atrophy is based on volumetric measurements such as the brain or the hippocampus, from patients with known disease and guided by clinical knowledge of the relative pathological involvement of regions and tissues. The consequent biomechanical readjustment of structures is modelled using conventional physics-based techniques based on biomechanical tissue properties and simulating plausible tissue deformations with finite-element methods. A thermoelastic model of tissue deformation is employed, controlling the rate of progression of atrophy by means of a set of thermal coefficients, each one corresponding to a different type of tissue. Tissue characterization is performed by means of the meshing of a labelled brain atlas, creating a reference volumetric mesh that will be introduced to a finite-element solver to create the simulated deformations. Preliminary work on the simulation of acquisition artefa- - cts is also presented. Cross-sectional and
A fast and robust patient specific Finite Element mesh registration technique: application to 60 clinical cases
Finite Element mesh generation remains an important issue for patient
specific biomechanical modeling. While some techniques make automatic mesh
generation possible, in most cases, manual mesh generation is preferred for
better control over the sub-domain representation, element type, layout and
refinement that it provides. Yet, this option is time consuming and not suited
for intraoperative situations where model generation and computation time is
critical. To overcome this problem we propose a fast and automatic mesh
generation technique based on the elastic registration of a generic mesh to the
specific target organ in conjunction with element regularity and quality
correction. This Mesh-Match-and-Repair (MMRep) approach combines control over
the mesh structure along with fast and robust meshing capabilities, even in
situations where only partial organ geometry is available. The technique was
successfully tested on a database of 5 pre-operatively acquired complete femora
CT scans, 5 femoral heads partially digitized at intraoperative stage, and 50
CT volumes of patients' heads. The MMRep algorithm succeeded in all 60 cases,
yielding for each patient a hex-dominant, Atlas based, Finite Element mesh with
submillimetric surface representation accuracy, directly exploitable within a
commercial FE software
Atlas-Based Prostate Segmentation Using an Hybrid Registration
Purpose: This paper presents the preliminary results of a semi-automatic
method for prostate segmentation of Magnetic Resonance Images (MRI) which aims
to be incorporated in a navigation system for prostate brachytherapy. Methods:
The method is based on the registration of an anatomical atlas computed from a
population of 18 MRI exams onto a patient image. An hybrid registration
framework which couples an intensity-based registration with a robust
point-matching algorithm is used for both atlas building and atlas
registration. Results: The method has been validated on the same dataset that
the one used to construct the atlas using the "leave-one-out method". Results
gives a mean error of 3.39 mm and a standard deviation of 1.95 mm with respect
to expert segmentations. Conclusions: We think that this segmentation tool may
be a very valuable help to the clinician for routine quantitative image
exploitation.Comment: International Journal of Computer Assisted Radiology and Surgery
(2008) 000-99
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