Remote Powering and Data Communication Over a Single Inductive Link for Implantable Medical Devices

RÉSUMÉ Les implants médicaux électroniques (Implantable Medical Devices - IMDs) sont notamment utilisés pour restaurer ou améliorer des fonctions perdues de certains organes. Ils sont capables de traiter des complications qui ne peuvent pas être guéries avec des médicaments ou par la chirurgie. Offrant des propriétés et des améliorations curatives sans précédent, les IMDs sont de plus en plus demandés par les médecins et les patients. En 2017, le marché mondial des IMD était évalué à 15,21 milliards de dollars. D’ici 2025, il devrait atteindre 30,42 mil-liards de dollars, soutenu par un taux de croissance annuel de 9,24% selon le nouveau rapport publié par Fior Markets. Cette expansion entraîne une augmentation des exigences pour as-surer des performances supérieures, des fonctionnalités supplémentaires et une durée de vie plus longue. Ces exigences ne peuvent être satisfaites qu’avec des techniques d’alimentation avancées, un débit de données élevé et une électronique miniaturisée robuste. Construire des systèmes capables de fournir toutes ces caractéristiques est l’objectif principal d’un grand nombre de chercheurs. Parmi plusieurs technologies sans fil, le lien inductif, qui consiste en une paire de bobines à couplage magnétique, est la technique sans fil la plus largement utilisée pour le transfert de puissance et de données. Cela est dû à sa simplicité, sa sécurité et sa capacité à transmettre à la fois de la puissance et des données de façon bidirectionnelle. Cependant, il existe encore un certain nombre de défis concernant la mise en œuvre d’un tel système de transfert d’énergie et de données sans fil (Wireless Power and Data Transfer - WPDT system). Un défi majeur est que les exigences pour une efficacité de transfert d’énergie élevée et pour une communication à haut débit sont contradictoires. En fait, la bande passante doit être élargie pour des débits de données élevés, mais réduite pour une transmission efficace de l’énergie. Un autre grand défi consiste à réaliser un démodulateur fonctionnant à haute vitesse avec une mise en œuvre simple et une consommation d’énergie ultra-faible. Dans ce projet, nous proposons et expérimentons un nouveau système WPDT dédié aux IMD permettant une communication à haute vitesse et une alimentation efficace tout en maintenant une faible consommation d’énergie, une petite surface de silicium et une mise en œuvre simple du récepteur. Le système proposé est basé sur un nouveau schéma de modulation appelé "Carrier Width Modulation (CWM)", ainsi que sur des circuits de modulation et de démodulation inédits. La modulation consiste en un coupe-circuit synchronisé du réservoir LC primaire pendant un ou deux cycles en fonction des données transmises.----------ABSTRACT Implantable Medical Devices (IMDs) are electronic implants notably used to restore or en-hance lost organ functions. They may treat complications that cannot be cured with medica-tion or through surgery. O˙ering unprecedented healing properties and enhancements, IMDs are increasingly requested by physicians and patients. In 2017, the worldwide IMD market was valued at USD 15,21 Billion. By 2025, it is expected to attain USD 30.42 Billion sus-tained by a compound annual growth rate of 9.24% according to a recent report published by Fior Markets. This expansion is bringing-up more demand for higher performance, additional features, and longer device lifespan and autonomy. These requirements can only be achieved with advanced power sources, high-data rates, and robust miniaturized electronics. Building systems able to provide all these characteristics is the main goal of many researchers. Among several wireless technologies, the inductive link, which consists of a magnetically-coupled pair of coils, is the most widely used wireless technique for both power and data transfer. This is due to its simplicity, safety, and ability to provide simultaneously both power and bidirectional data transfer to the implant. However there are still a number of challenges regarding the implementation of such Wireless Power and Data Transfer (WPDT) systems. One main challenge is that the requirements for high Power Transfer Eÿciency (PTE) and for high-data rate communication are contra-dictory. In fact, the bandwidth needs to be widened for high data rates, but narrowed for eÿcient power delivery. Another big challenge is to implement a high-speed demodulator with simple implementation and ultra-low power consumption. In this project, we propose and experiment a new WPDT system dedicated to IMDs allow-ing high-speed communication and eÿcient power delivery, while maintaining a low power consumption, small silicon area, and simple implementation of the receiver. The proposed system is based on a new Carrier Width Modulation (CWM) scheme, as well as novel modu-lation and demodulation circuits. The modulation consists of a synchronized opening of the primary LC tank for one or two cycles according to the transmitted data. Unlike conventional modulation techniques, the data rate of the proposed CWM modulation is not limited by the quality factors of the primary and secondary coils. On the other hand, the proposed CWM demodulator allows higher-speed demodulation and simple implementation, unlike conven-tional demodulators for a similar modulation scheme. It also o˙ers a wide range of data rates under any selected frequency from 10 to 31 MHz

Millimeter-Scale and Energy-Efficient RF Wireless System

This dissertation focuses on energy-efficient RF wireless system with millimeter-scale dimension, expanding the potential use cases of millimeter-scale computing devices. It is challenging to develop RF wireless system in such constrained space. First, millimeter-sized antennae are electrically-small, resulting in low antenna efficiency. Second, their energy source is very limited due to the small battery and/or energy harvester. Third, it is required to eliminate most or all off-chip devices to further reduce system dimension. In this dissertation, these challenges are explored and analyzed, and new methods are proposed to solve them. Three prototype RF systems were implemented for demonstration and verification. The first prototype is a 10 cubic-mm inductive-coupled radio system that can be implanted through a syringe, aimed at healthcare applications with constrained space. The second prototype is a 3x3x3 mm far-field 915MHz radio system with 20-meter NLOS range in indoor environment. The third prototype is a low-power BLE transmitter using 3.5x3.5 mm planar loop antenna, enabling millimeter-scale sensors to connect with ubiquitous IoT BLE-compliant devices. The work presented in this dissertation improves use cases of millimeter-scale computers by presenting new methods for improving energy efficiency of wireless radio system with extremely small dimensions. The impact is significant in the age of IoT when everything will be connected in daily life.PHDElectrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/147686/1/yaoshi_1.pd

Frequency splitting elimination and cross-coupling rejection of wireless power transfer to multiple dynamic receivers

Simultaneous power transfer to multiple receiver (Rx) system is one of the key advantages of wireless power transfer (WPT) system using magnetic resonance. However, determining the optimal condition to uniformly transfer the power to a selected Rx at high efficiency is the challenging task under the dynamic environment. The cross-coupling and frequency splitting are the dominant issues present in the multiple Rx dynamic WPT system. The existing analysis is performed by considering any one issue present in the system; on the other hand, the cross coupling and frequency splitting issues are interrelated in dynamic Rx’s, which requires a comprehensive design strategy by considering both the problems. This paper proposes an optimal design of multiple Rx WPT system, which can eliminate cross coupling, frequency splitting issues and increase the power transfer efficiency (PTE) of selected Rx. The cross-coupling rejection, uniform power transfer is performed by adding an additional relay coil and independent resonance frequency tuning with capacitive compensation to each Rx unit. The frequency splitting phenomena are eliminated using non-identical transmitter (Tx) and Rx coil structure which can maintain the coupling between the coil under the critical coupling limit. The mathematical analysis of the compensation capacitance calculation and optimal Tx coil size identification is performed for the four Rx WPT system. Finite element analysis and experimental investigation are carried out for the proposed design in static and dynamic conditions

Assessing the Intrinsic Radiation Efficiency of Tissue Implanted UHF Antennas

Dielectric loss occurring in tissues in close proximity to UHF implanted antennas is an important factor in the performance of medical implant communication systems. Common practice in numerical analysis and testing is to utilize radiation efficiency measures external to the tissue phantom employed. This approach means that radiation efficiency is also dependent on the phantom used and antenna positioning, making it difficult to understand antenna performance and minimize near-field tissue losses. Therefore, an alternative methodology for determining the intrinsic radiation performance of implanted antennas that focuses on assessing structural and near field tissue losses is presented. The new method is independent of the tissue phantom employed and can be used for quantitative comparison of designs across different studies. The intrinsic radiation efficiency of an implant antenna is determined by assessing the power flow within the tissue phantom at a distance of at least λg/2 from the radiating structure. Simulated results are presented for canonical antennas at 403 MHz and 2400 MHz in homogeneous muscle and fat phantoms. These illustrate the dominance of propagating path losses in high-water content tissues such as muscle, whereas nearfield dielectric losses may be more important in low-water tissues such as fat due to the extended reactive near-field

超軽負荷領域を含む高効率な磁界共振型非接触給電システムの構築

研究種目：若手研究(B)研究期間：2017～2018課題番号：17K14642研究代表者：宮地　幸祐研究者番号：80635467Other2017～2018年度科学研究費助成事業（若手研究(B)）研究成果報告書　課題番号：17K14642　研究代表者：宮地　幸祐research repor

Wireless Implantable ICs for Energy-Efficient Long-Term Ambulatory EEG Monitoring

This thesis presents the design, development, and experimental characterization of wireless subcutaneous implantable integrated circuits and systems for long-term ambulatory EEG monitoring. Application-, system- and circuit-level requirements for such a device are discussed and a critical review of the state-of-the-art academic and currently available commercial solutions are provided. Two prototypes are presented: The first prototype presented in Chapter 2 is an 8-channel wireless implantable device with a 2.5×1.5 mm2 custom-designed integrated circuit implemented using CMOS 180nm technology at its core. The microchip is fabricated and the measurement results showing its efficacy in EEG signal recording in terms of input-referred noise, voltage gain, signal-to-noise ratio, and power consumption are presented. The chip is implemented together with a BLE 5.0 module on the same platform. Our vision and discussions on biocompatible encapsulation of this system, as well as its integration with a microelectrode array as also provided. The second prototype, also implemented in CMOS 180nm technology and presented in Chapter 3, employs a novel EEG recording channel architecture that enables long-term implantation of EEG monitoring devices through significant improvement of their energy efficiency. The channel leverages the inherent sparsity of the EEG signals and conducts recording in an activity-dependent adaptive manner. Thanks to the proposed fully dynamic spectral-compressing architecture, the recording channels power consumption is drastically reduced. More importantly, the proposed architecture reduces the required wireless transmission throughput by more than an order of magnitude. Our test results on 10 different patients’ pre-recorded human EEG data shows an average of 12.6× improvement in the device’s energy efficiency

45-nm SOI CMOS Bluetooth Electrochemical Sensor for Continuous Glucose Monitoring

Due to increasing rates of diabetes, non-invasive glucose monitoring systems will become critical to improving health outcomes for an increasing patient population. Bluetooth integration for such a system has been previously unattainable due to the prohibitive energy consumption. However, enabling Bluetooth allows for widespread adoption due to the ubiquity of Bluetooth-enabled mobile devices. The objective of this thesis is to demonstrate the feasibility of a Bluetooth-based energy-harvesting glucose sensor for contact-lens integration using 45~nm silicon-on-insulator (SOI) complementary metal-oxide-semiconductor (CMOS) technology. The proposed glucose monitoring system includes a Bluetooth transmitter implemented as a two-point closed loop PLL modulator, a sensor potentiostat, and a 1st-order incremental delta-sigma analog-to-digital converter (IADC). This work details the complete system design including derivation of top-level specifications such as glucose sensing range, Bluetooth protocol timing, energy consumption, and circuit specifications such as carrier frequency range, output power, phase-noise performance, stability, resolution, signal-to-noise ratio, and power consumption. Three test chips were designed to prototype the system, and two of these were experimentally verified. Chip 1 includes a partial implementation of a phase-locked-loop (PLL) which includes a voltage-controlled-oscillator (VCO), frequency divider, and phase-frequency detector (PFD). Chip 2 includes the design of the sensor potentiostat and IADC. Finally, Chip 3 combines the circuitry of Chip 1 and Chip 2, along with a charge-pump, loop-filter and power amplifier to complete the system. Chip 1 DC power consumption was measured to be 204.8~$\mu$W, while oscillating at 2.441 GHz with an output power $P_{out}$ of -35.8 dBm, phase noise at 1 MHz offset $L(1\text{ MHz})$ of -108.5 dBc/Hz, and an oscillator figure of merit (FOM) of 183.44dB. Chip 2 achieves a total DC power consumption of 5.75~$\mu$W. The system has a dynamic range of 0.15~nA -- 100~nA at 10-bit resolution. The integral non-linearity (INL) and differential non-linearity (DNL) of the IADC were measured to be -6~LSB/$\pm$0.3~LSB respectively with a conversion time of 65.56~ms. This work achieves the best duty-cycled DC power consumption compared to similar glucose monitoring systems, while providing sufficient performance and range using Bluetooth

High-Efficiency Low-Voltage Rectifiers for Power Scavenging Systems

Abstract Rectifiers are commonly used in electrical energy conversion chains to transform the energy obtained from an AC signal source to a DC level. Conventional bridge and gate cross-coupled rectifier topologies are not sufficiently power efficient, particularly when input amplitudes are low. Depending on their rectifying element, their power efficiency is constrained by either the forward-bias voltage drop of a diode or the threshold voltage of a diode-connected MOS transistor. Advanced passive rectifiers use threshold cancellation techniques to effectively reduce the threshold voltage of MOS diodes. Active rectifiers use active circuits to control the conduction angle of low-loss MOS switches. In this thesis, an active rectifier with a gate cross-coupled topology is proposed, which replaces the diode-connected MOS transistors of a conventional rectifier with low-loss MOS switches. Using the inherent characteristics of MOS transistors as comparators, dynamic biasing of the bulks of main switches and small pull-up transistors, the proposed self-supplied active rectifier exhibits smaller voltage drop across the main switches leading to a higher power efficiency compared to conventional rectifier structures for a wide range of operating frequencies in the MHz range. Delivery of high load currents is another feature of the proposed rectifier. Using the bootstrapping technique, single- and double-reservoir based rectifiers are proposed. They present higher power and voltage conversion efficiencies compared to conventional rectifier structures. With a source amplitude of 3.3 V, when compared to the gate cross-coupled topology, the proposed active rectifier offers power and voltage conversion efficiencies improved by up to 10% and 16% respectively. The proposed rectifier using the bootstrap technique, including double- and single-reservoir schemes, are well suited for very low input amplitudes. They present power and voltage conversion efficiencies of 75% and 76% at input amplitude of 1.0 V and maintain their high efficiencies over input amplitudes greater than 1.0V. Single-reservoir bootstrap rectifier also reduces die area by 70% compared to its double-reservoir counterpart.---------Résumé Les redresseurs sont couramment utilisés dans de nombreux systèmes afin de transformer l'énergie électrique obtenue à partir d'une source alternative en une alimentation continue. Les topologies traditionnelles telles que les ponts de diodes et les redresseurs se servant de transistors à grilles croisées-couplées ne sont pas suffisamment efficaces en terme d’énergie, en particulier pour des signaux à faibles amplitudes. Dépendamment de leur élément de redressement, leur efficacité en termes de consommation d’énergie est limitée soit par la chute de tension de polarisation directe d'une diode, soit par la tension de seuil du transistor MOS. Les redresseurs passifs avancés utilisent une technique de conception pour réduire la tension de seuil des diodes MOS. Les redresseurs actifs utilisent des circuits actifs pour contrôler l'angle de conduction des commutateurs MOS à faible perte. Dans cette thèse, nous avons proposé un redresseur actif avec une topologie en grille croisée-couplée. Elle utilise des commutateurs MOS à faible perte à la place des transistors MOS connectés en diode comme redresseurs. Le circuit proposé utilise: des caractéristiques intrinsèques des transistors MOS pour les montages comparateurs et une polarisation dynamique des substrats des commutateurs principaux supportés par de petits transistors de rappel. Le redresseur proposé présente des faibles chutes de tension à travers le commutateur principal menant à une efficacité de puissance plus élevée par rapport aux structures d’un redresseur conventionnel pour une large gamme de fréquences de fonctionnement de l’ordre des MHz. La conduction des courants de charge élevée est une autre caractéristique du redresseur proposé. En utilisant la méthode de bootstrap, des redresseurs à simple et à double réservoir sont proposés. Ils présentent une efficacité de puissance et un rapport de conversion de tension élevés en comparaison avec les structures des redresseurs conventionnels. Avec une amplitude de source de 3,3 V, le redresseur proposé offre des efficacités de puissance et de conversion de tension améliorées par rapport au circuit à transistors croisés couplés. Ces améliorations atteignent 10% et 16% respectivement. Les redresseurs proposés utilisent la technique de bootstrap. Ils sont bien adaptés pour des amplitudes d'entrée très basses. À une amplitude d'entrée de 1,0 V, ces derniers redresseurs présentent des rendements de conversion de puissance et de tension de 75% et 76%. Le redresseur à simple réservoir réduit également l’aire de silicium requise de 70% par rapport à la version à double-réservoir

A Closed-Loop Bidirectional Brain-Machine Interface System For Freely Behaving Animals

A brain-machine interface (BMI) creates an artificial pathway between the brain and the external world. The research and applications of BMI have received enormous attention among the scientific community as well as the public in the past decade. However, most research of BMI relies on experiments with tethered or sedated animals, using rack-mount equipment, which significantly restricts the experimental methods and paradigms. Moreover, most research to date has focused on neural signal recording or decoding in an open-loop method. Although the use of a closed-loop, wireless BMI is critical to the success of an extensive range of neuroscience research, it is an approach yet to be widely used, with the electronics design being one of the major bottlenecks. The key goal of this research is to address the design challenges of a closed-loop, bidirectional BMI by providing innovative solutions from the neuron-electronics interface up to the system level. Circuit design innovations have been proposed in the neural recording front-end, the neural feature extraction module, and the neural stimulator. Practical design issues of the bidirectional neural interface, the closed-loop controller and the overall system integration have been carefully studied and discussed.To the best of our knowledge, this work presents the first reported portable system to provide all required hardware for a closed-loop sensorimotor neural interface, the first wireless sensory encoding experiment conducted in freely swimming animals, and the first bidirectional study of the hippocampal field potentials in freely behaving animals from sedation to sleep. This thesis gives a comprehensive survey of bidirectional BMI designs, reviews the key design trade-offs in neural recorders and stimulators, and summarizes neural features and mechanisms for a successful closed-loop operation. The circuit and system design details are presented with bench testing and animal experimental results. The methods, circuit techniques, system topology, and experimental paradigms proposed in this work can be used in a wide range of relevant neurophysiology research and neuroprosthetic development, especially in experiments using freely behaving animals