Communication and energy delivery architectures for personal medical devices

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 219-232).Advances in sensor technologies and integrated electronics are revolutionizing how humans access and receive healthcare. However, many envisioned wearable or implantable systems are not deployable in practice due to high energy consumption and anatomically-limited size constraints, necessitating large form-factors for external devices, or eventual surgical re-implantation procedures for in-vivo applications. Since communication and energy-management sub-systems often dominate the power budgets of personal biomedical devices, this thesis explores alternative usecases, system architectures, and circuit solutions to reduce their energy burden. For wearable applications, a system-on-chip is designed that both communicates and delivers power over an eTextiles network. The transmitter and receiver front-ends are at least an order of magnitude more efficient than conventional body-area networks. For implantable applications, two separate systems are proposed that avoid reimplantation requirements. The first system extracts energy from the endocochlear potential, an electrochemical gradient found naturally within the inner-ear of mammals, in order to power a wireless sensor. Since extractable energy levels are limited, novel sensing, communication, and energy management solutions are proposed that leverage duty-cycling to achieve enabling power consumptions that are at least an order of magnitude lower than previous work. Clinical measurements show the first system demonstrated to sustain itself with a mammalian-generated electrochemical potential operating as the only source of energy into the system. The second system leverages the essentially unlimited number of re-charge cycles offered by ultracapacitors. To ease patient usability, a rapid wireless capacitor charging architecture is proposed that employs a multi-tapped secondary inductive coil to provide charging times that are significantly faster than conventional approaches.by Patrick Philip Mercier.Ph.D

Wearable, low-power CMOS ISFETs and compensation circuits for on-body sweat analysis

Complementary metal-oxide-semiconductor (CMOS) technology has been a key driver behind the trend of reduced power consumption and increased integration of electronics in consumer devices and sensors. In the late 1990s, the integration of ion-sensitive field-effect transistors (ISFETs) into unmodified CMOS helped to create advancements in lab-on-chip technology through highly parallelised and low-cost designs. Using CMOS techniques to reduce power and size in chemical sensing applications has already aided the realisation of portable, battery-powered analysis platforms, however the possibility of integrating these sensors into wearable devices has until recently remained unexplored. This thesis investigates the use of CMOS ISFETs as wearable electrochemical sensors, specifically for on-body sweat analysis. The investigation begins by evaluating the ISFET sensor for wearable applications, identifying the key advantages and challenges that arise in this pursuit. A key requirement for wearable devices is a low power consumption, to enable a suitable operational life and small form factor. From this perspective, ISFETs are investigated for low power operation, to determine the limitations when trying to push down the consumption of individual sensors. Batteryless ISFET operation is explored through the design and implementation of a 0.35 \si{\micro\metre} CMOS ISFET sensing array, operating in weak-inversion and consuming 6 \si{\micro\watt}. Using this application-specific integrated circuit (ASIC), the first ISFET array powered by body heat is demonstrated and the feasibility of using near-field communication (NFC) for wireless powering and data transfer is shown. The thesis also presents circuits and systems for combatting three key non-ideal effects experienced by CMOS ISFETs, namely temperature variation, threshold voltage offset and drift. An improvement in temperature sensitivity by a factor of three compared to an uncompensated design is shown through measured results, while adding less than 70 \si{\nano\watt} to the design. A method of automatically biasing the sensors is presented and an approach to using spatial separation of sensors in arrays in applications with flowing fluids is proposed for distinguishing between signal and sensor drift. A wearable device using the ISFET-based system is designed and tested with both artificial and natural sweat, identifying the remaining challenges that exist with both the sensors themselves and accompanying components such as microfluidics and reference electrode. A new ASIC is designed based on the discoveries of this work and aimed at detecting multiple analytes on a single chip. %Removed In the latter half of the thesis, Finally, the future directions of wearable electrochemical sensors is discussed with a look towards embedded machine learning to aid the interpretation of complex fluid with time-domain sensor arrays. The contributions of this thesis aim to form a foundation for the use of ISFETs in wearable devices to enable non-invasive physiological monitoring.Open Acces

Wireless Transceivers for Implantable Microsystems.

In this thesis, we present the first-ever fully integrated mm3 low-power biomedical transceiver with 1 meter of range that is powered by a mm2 thin-film battery. The transceiver is targeted for biomedical implants where size and energy constraints dictated by application make design challenging. Despite all the previous work in RFID tags, form factor of such radios is incompatible with mm3 biomedical implants. The proposed transceiver bridges this gap by providing a compact low-power solution that can run off small thin-film batteries and can be stacked with other system components in a 3D fashion. On the sensor-to-external side, we proposed a novel FSK architecture based on dual-resonator LC oscillators to mitigate unwanted overlap of two FSK tones’ phase noise spectrum. Due to inherent complexity of such systems, fourth order dual-resonator oscillators can exhibit instable operation. We mathematically modeled the instability and derive design conditions for stable oscillations. Through simulation and measurements, validity of derived models was confirmed. Together with other low-power system blocks, the transmitter was successfully implanted in live mouse and in-vivo measurements were performed to confirm successful transmission of vital signals through organic tissue. The integrated transmitter achieved a bit-error-rate of 10-6 at 10cm with 4.7nJ/bit energy consumption. On the external-to-sensor link, we proposed a new protocol to lower receiver peak power, which is highly limited due to small size of mm3 microsystem battery. In the proposed protocol, sending same data multiple times drastically relaxes jitter requirement on the sensor side at the cost of increased power consumption on the external side without increasing peak power radiated by the external unit. The receiver also uses a dual-coil LNA to improve range by 22% with only 11% area overhead. An asynchronous controller manages protocol timing and limits total monitoring current to 43nA. The fabricated receiver consumes 1.6nJ/bit at 40kbps while positioned 1m away from a 2W source.PhDElectrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/102458/1/ghaed_1.pd

Wide Bandgap Based Devices: Design, Fabrication and Applications, Volume II

Wide bandgap (WBG) semiconductors are becoming a key enabling technology for several strategic fields, including power electronics, illumination, and sensors. This reprint collects the 23 papers covering the full spectrum of the above applications and providing contributions from the on-going research at different levels, from materials to devices and from circuits to systems

Integrated Microsystems for Wireless Sensing Applications

Personal health monitoring is being considered the future of a sustainable health care system. Biosensing platforms are a very important component of this system. Real-time and accurate sensing is essential for the success of personal health care model. Currently, there are many efforts going on to make these sensors practical and more useful for such measurements. Implantable sensors are considered the most widely applicable and most reliable sensors for such accurate health monitoring applications. However, macroscopic (cm scale) size has proved to be a limiting factor for successful use of these systems for long time and in large numbers. This work is focused to resolve the issues related with miniaturizing these devices to a microscopic (mm scale) size scale which can minimize many practical difficulties associated with their larger counterparts currently. To accomplish this goal of miniaturization while retaining or even improving on the necessary capabilities for such sensing platforms, an integrated approach is presented which focuses on system-level miniaturization using standard fabrication procedures. First, it is shown that a completely integrated and wireless system is the best solution to achieve desired miniaturization without sacrificing the functionality of the system. Hence, design and implementation of the different components comprising the complete system needs to be done according to the requirements of the overall integrated system. This leads to the need of on-chip functional sensors, integrated wireless power supply, integrated wireless communication and integrated control system for realization of such system. In this work, different options for implementation of each of these subsystems are compared and an optimal solution is presented for each subsystem. For such complex systems, it is imperative to use a standard fabrication process which can provide the required functionality for all subsystems at smallest possible size scale. Complementary Metal Oxide Semiconductor (CMOS) process is the most appropriate of the technologies in this regard and has enabled incredible miniaturization of the computing industry. It also provides options for designing different subsystems on the same platform in a monolithic process with very high yield. This choice then leads to actual designs of subsystems in the CMOS technology using different possible methods. Careful comparison of these subsystems provides insights into different design adjustments that are made until the desired functions are achieved at the desired size scale. Integration of all these compatible subsystems in the same platform is shown to provide the smallest possible sensing platform to date. The completely wireless system can measure a host of different important analyte and can transmit the data to an external device which can use it for appropriate purpose. Results on measurements in phosphate buffer solution, blood serum and whole blood along with wireless communication in real biological tissues are provided. Specific examples of glucose and DNA sensors are presented and the use for many other relevant applications is also proposed. Finally, insights into animal model studies and future directions of the research are discussed. </p

EUROSENSORS XVII : book of abstracts

Fundação Calouste Gulbenkien (FCG).Fundação para a Ciência e a Tecnologia (FCT)