Chopper-stabilized high-pass delta-sigma modulators.

Zhao, Yinsheng.Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.Includes bibliographical references (leaves 90-93).Abstracts in English and Chinese.ABSTRACT --- p.I摘要 --- p.IICONTENTS --- p.IIILIST OF FIGURES --- p.VLIST OF TABLES --- p.VIIACKNOWLEDGEMENT --- p.VIIIChapter CHAPTER 1 --- INTRODUCTION --- p.1Chapter 1.1 --- MOTIVATION --- p.1Chapter 1.2 --- ORGANIZATION OF THE THESIS --- p.5Chapter CHAPTER 2 --- BASIC THEOREMS OF DELTA SIGMA ADC --- p.6Chapter 2.1 --- INTRODUCTION TO SAMPLING TECHNIQUE --- p.6Chapter 2.2 --- DELTA-SIGMA ORDER & NOISE-SHAPING ORDER --- p.8Chapter 2.2.1 --- FIRST ORDER CLELTA-SIGMA MODULATOR --- p.8Chapter 2.2.2 --- HIGH ORDER DELTA-SIGMA MODULATOR --- p.11Chapter 2.3 --- CHOPPER-STABILIZATION TECHNIQUE --- p.13Chapter 2.4 --- MIRRORED INTEGRATOR --- p.16Chapter 2.5 --- PERFORMANCE METRICS --- p.18Chapter 2.5.1 --- SIGNAL TO NOISE RATIO (SNR) --- p.18Chapter 2.5.2 --- SIGNAL TO NOISE AND DISTORTION RATIO (SNDR) --- p.19Chapter 2.5.3 --- DYNAM IC RANGE --- p.19Chapter 2.5.4 --- EFFECTIVE NUMBER OF BITS --- p.19Chapter 2.5.5 --- "OVERLOAD LEVER, XOL" --- p.19Chapter 2.6 --- CONCLUSION --- p.20Chapter CHAPTER 3 --- NON-IDEALITIES IN SYSTEM MODELING --- p.21Chapter 3.1 --- CLOCK JITTER --- p.21Chapter 3.2 --- NON-IDEAL EFFECT OF OPERATIONAL AMPLIFIER --- p.23Chapter 3.2.1 --- FINITE OPEN-LOOP GAIN --- p.23Chapter 3.2.2 --- FINITE BANDWIDTH AND SLEW-RATE --- p.24Chapter 3.3 --- CAPACITOR RATIO ERROR --- p.26Chapter 3.4 --- THERMAL NOISE --- p.27Chapter 3.5 --- SWITCH CHARGE INJECTION ERROR --- p.30Chapter 3.6 --- CONCLUSION --- p.34Chapter CHAPTER 4 --- A CHOPPER-STABILIZED HIGH-PASS DELTA-SIGMA MODULATOR IN 1.8V 0.18MM CMOS --- p.35Chapter 4.1 --- STRUCTURE SELECTION --- p.35Chapter 4.2 --- SYSTEM MODELING AND PARAMETER SELECTION --- p.38Chapter 4.3 --- CIRCUIT IMPLEMENTATION --- p.42Chapter 4.3.1 --- OPERATIONAL AMPLIFIER --- p.42Chapter 4.3.2 --- QUANTIZER --- p.44Chapter 4.3.3 --- FREQUENCY DIVIDER --- p.47Chapter 4.3.4 --- OVERALL CIRCUIT --- p.48Chapter 4.4 --- LAYOUT IMPLEMENTATION --- p.50Chapter 4.4.1 --- LAYOUT SYMMETRIC TECHNIQUE --- p.50Chapter 4.4.2 --- CIRCUIT LAYOUT --- p.53Chapter 4.4.3 --- FLOOR PLANNING AND TOP LEVEL INTER-CONNECT!ON --- p.56Chapter 4.5 --- MEASUREMENT RESULTS --- p.58Chapter CHAPTER 5 --- A LOW-POWER CHOPPER-STABILIZED DELTA-SIGMA MODULATOR IN 1.2V0.18MM CMOS --- p.63Chapter 5.1 --- STRUCTURE SELECTION --- p.63Chapter 5.2 --- SYSTEM MODELING AND PARAMETER SELECTION --- p.67Chapter 5.3 --- CIRCUIT IMPLEMENTATION --- p.70Chapter 5.3.1 --- OPERATIONAL AMPLIFIER --- p.70Chapter 5.3.2 --- QUANTIZER --- p.73Chapter 5.3.3 --- LARGE DELAY GENERATION --- p.73Chapter 5.3.4 --- OVERALL CIRCUIT --- p.75Chapter 5.4 --- SIMULATION RESULTS --- p.77Chapter CHAPTER 6 --- DECIMATION FILTER DESIGN --- p.79Chapter 6.1. --- THE WHOLE VIEW OF DECIMATION FILTER --- p.79Chapter 6.2. --- THE DECIMATION FILTER IN SIMULINK --- p.80Chapter 6.2.1 --- SINE FILTER DESIGN --- p.80Chapter 6.2.2 --- HALF-BAND FILTER DESIGN --- p.82Chapter CHAPTER 7 --- CONCLUSIONS AND FUTURE WORKS --- p.88Chapter 7.1. --- CONCLUSIONS --- p.88Chapter 7.2. --- FUTURE WORKS --- p.89REFERENCES --- p.90PUBLICATION --- p.9

Ultra-low power mixed-signal frontend for wearable EEGs

Electronics circuits are ubiquitous in daily life, aided by advancements in the chip design industry, leading to miniaturised solutions for typical day to day problems. One of the critical healthcare areas helped by this advancement in technology is electroencephalography (EEG). EEG is a non-invasive method of tracking a person's brain waves, and a crucial tool in several healthcare contexts, including epilepsy and sleep disorders. Current ambulatory EEG systems still suffer from limitations that affect their usability. Furthermore, many patients admitted to emergency departments (ED) for a neurological disorder like altered mental status or seizures, would remain undiagnosed hours to days after admission, which leads to an elevated rate of death compared to other conditions. Conducting a thorough EEG monitoring in early-stage could prevent further damage to the brain and avoid high mortality. But lack of portability and ease of access results in a long wait time for the prescribed patients. All real signals are analogue in nature, including brainwaves sensed by EEG systems. For converting the EEG signal into digital for further processing, a truly wearable EEG has to have an analogue mixed-signal front-end (AFE). This research aims to define the specifications for building a custom AFE for the EEG recording and use that to review the suitability of the architectures available in the literature. Another critical task is to provide new architectures that can meet the developed specifications for EEG monitoring and can be used in epilepsy diagnosis, sleep monitoring, drowsiness detection and depression study. The thesis starts with a preview on EEG technology and available methods of brainwaves recording. It further expands to design requirements for the AFE, with a discussion about critical issues that need resolving. Three new continuous-time capacitive feedback chopped amplifier designs are proposed. A novel calibration loop for setting the accurate value for a pseudo-resistor, which is a crucial block in the proposed topology, is also discussed. This pseudoresistor calibration loop achieved the resistor variation of under 8.25%. The thesis also presents a new design of a curvature corrected bandgap, as well as a novel DDA based fourth-order Sallen-Key filter. A modified sensor frontend architecture is then proposed, along with a detailed analysis of its implementation. Measurement results of the AFE are finally presented. The AFE consumed a total power of 3.2A (including ADC, amplifier, filter, and current generation circuitry) with the overall integrated input-referred noise of 0.87V-rms in the frequency band of 0.5-50Hz. Measurement results confirmed that only the proposed AFE achieved all defined specifications for the wearable EEG system with the smallest power consumption than state-of-art architectures that meet few but not all specifications. The AFE also achieved a CMRR of 131.62dB, which is higher than any studied architectures.Open Acces

Design, analysis and evaluation of sigma-delta based beamformers for medical ultrasound imaging applications

The inherent analogue nature of medical ultrasound signals in conjunction with the abundant merits provided by digital image acquisition, together with the increasing use of relatively simple front-end circuitries, have created considerable demand for single-bit beamformers in digital ultrasound imaging systems. Furthermore, the increasing need to design lightweight ultrasound systems with low power consumption and low noise, provide ample justification for development and innovation in the use of single-bit beamformers in ultrasound imaging systems. The overall aim of this research program is to investigate, establish, develop and confirm through a combination of theoretical analysis and detailed simulations, that utilize raw phantom data sets, suitable techniques for the design of simple-to-implement hardware efficient digital ultrasound beamformers to address the requirements for 3D scanners with large channel counts, as well as portable and lightweight ultrasound scanners for point-of-care applications and intravascular imaging systems. In addition, the stability boundaries of higher-order High-Pass (HP) and Band-Pass (BP) Σ−Δ modulators for single- and dual- sinusoidal inputs are determined using quasi-linear modeling together with the describing-function method, to more accurately model the modulator quantizer. The theoretical results are shown to be in good agreement with the simulation results for a variety of input amplitudes, bandwidths, and modulator orders. The proposed mathematical models of the quantizer will immensely help speed up the design of higher order HP and BP Σ−Δ modulators to be applicable for digital ultrasound beamformers. Finally, a user friendly design and performance evaluation tool for LP, BP and HP modulators is developed. This toolbox, which uses various design methodologies and covers an assortment of modulators topologies, is intended to accelerate the design process and evaluation of modulators. This design tool is further developed to enable the design, analysis and evaluation of beamformer structures including the noise analyses of the final B-scan images. Thus, this tool will allow researchers and practitioners to design and verify different reconstruction filters and analyze the results directly on the B-scan ultrasound images thereby saving considerable time and effort

A Low-Power, Reconfigurable, Pipelined ADC with Automatic Adaptation for Implantable Bioimpedance Applications

Biomedical monitoring systems that observe various physiological parameters or electrochemical reactions typically cannot expect signals with fixed amplitude or frequency as signal properties can vary greatly even among similar biosignals. Furthermore, advancements in biomedical research have resulted in more elaborate biosignal monitoring schemes which allow the continuous acquisition of important patient information. Conventional ADCs with a fixed resolution and sampling rate are not able to adapt to signals with a wide range of variation. As a result, reconfigurable analog-to-digital converters (ADC) have become increasingly more attractive for implantable biosensor systems. These converters are able to change their operable resolution, sampling rate, or both in order convert changing signals with increased power efficiency. Traditionally, biomedical sensing applications were limited to low frequencies. Therefore, much of the research on ADCs for biomedical applications focused on minimizing power consumption with smaller bias currents resulting in low sampling rates. However, recently bioimpedance monitoring has become more popular because of its healthcare possibilities. Bioimpedance monitoring involves injecting an AC current into a biosample and measuring the corresponding voltage drop. The frequency of the injected current greatly affects the amplitude and phase of the voltage drop as biological tissue is comprised of resistive and capacitive elements. For this reason, a full spectrum of measurements from 100 Hz to 10-100 MHz is required to gain a full understanding of the impedance. For this type of implantable biomedical application, the typical low power, low sampling rate analog-to-digital converter is insufficient. A different optimization of power and performance must be achieved. Since SAR ADC power consumption scales heavily with sampling rate, the converters that sample fast enough to be attractive for bioimpedance monitoring do not have a figure-of-merit that is comparable to the slower converters. Therefore, an auto-adapting, reconfigurable pipelined analog-to-digital converter is proposed. The converter can operate with either 8 or 10 bits of resolution and with a sampling rate of 0.1 or 20 MS/s. Additionally, the resolution and sampling rate are automatically determined by the converter itself based on the input signal. This way, power efficiency is increased for input signals of varying frequency and amplitude

Performance enhancement in the desing of amplifier and amplifier-less circuits in modern CMOS technologies.

In the context of nowadays CMOS technology downscaling and the increasing demand of high performance electronics by industry and consumers, analog design has become a major challenge. On the one hand, beyond others, amplifiers have traditionally been a key cell for many analog systems whose overall performance strongly depends on those of the amplifier. Consequently, still today, achieving high performance amplifiers is essential. On the other hand, due to the increasing difficulty in achieving high performance amplifiers in downscaled modern technologies, a different research line that replaces the amplifier by other more easily achievable cells appears: the so called amplifier-less techniques. This thesis explores and contributes to both philosophies. Specifically, a lowvoltage differential input pair is proposed, with which three multistage amplifiers in the state of art are designed, analysed and tested. Moreover, a structure for the implementation of differential switched capacitor circuits, specially suitable for comparator-based circuits, that features lower distortion and less noise than the classical differential structures is proposed, an, as a proof of concept, implemented in a ΔΣ modulator

Low-Power Low-Noise CMOS Analog and Mixed-Signal Design towards Epileptic Seizure Detection

About 50 million people worldwide suffer from epilepsy and one third of them have seizures that are refractory to medication. In the past few decades, deep brain stimulation (DBS) has been explored by researchers and physicians as a promising way to control and treat epileptic seizures. To make the DBS therapy more efficient and effective, the feedback loop for titrating therapy is required. It means the implantable DBS devices should be smart enough to sense the brain signals and then adjust the stimulation parameters adaptively. This research proposes a signal-sensing channel configurable to various neural applications, which is a vital part for a future closed-loop epileptic seizure stimulation system. This doctoral study has two main contributions, 1) a micropower low-noise neural front-end circuit, and 2) a low-power configurable neural recording system for both neural action-potential (AP) and fast-ripple (FR) signals. The neural front end consists of a preamplifier followed by a bandpass filter (BPF). This design focuses on improving the noise-power efficiency of the preamplifier and the power/pole merit of the BPF at ultra-low power consumption. In measurement, the preamplifier exhibits 39.6-dB DC gain, 0.8 Hz to 5.2 kHz of bandwidth (BW), 5.86-μVrms input-referred noise in AP mode, while showing 39.4-dB DC gain, 0.36 Hz to 1.3 kHz of BW, 3.07-μVrms noise in FR mode. The preamplifier achieves noise efficiency factor (NEF) of 2.93 and 3.09 for AP and FR modes, respectively. The preamplifier power consumption is 2.4 μW from 2.8 V for both modes. The 6th-order follow-the-leader feedback elliptic BPF passes FR signals and provides -110 dB/decade attenuation to out-of-band interferers. It consumes 2.1 μW from 2.8 V (or 0.35 μW/pole) and is one of the most power-efficient high-order active filters reported to date. The complete front-end circuit achieves a mid-band gain of 38.5 dB, a BW from 250 to 486 Hz, and a total input-referred noise of 2.48 μVrms while consuming 4.5 μW from the 2.8 V power supply. The front-end NEF achieved is 7.6. The power efficiency of the complete front-end is 0.75 μW/pole. The chip is implemented in a standard 0.6-μm CMOS process with a die area of 0.45 mm^2. The neural recording system incorporates the front-end circuit and a sigma-delta analog-to-digital converter (ADC). The ADC has scalable BW and power consumption for digitizing both AP and FR signals captured by the front end. Various design techniques are applied to the improvement of power and area efficiency for the ADC. At 77-dB dynamic range (DR), the ADC has a peak SNR and SNDR of 75.9 dB and 67 dB, respectively, while consuming 2.75-mW power in AP mode. It achieves 78-dB DR, 76.2-dB peak SNR, 73.2-dB peak SNDR, and 588-μW power consumption in FR mode. Both analog and digital power supply voltages are 2.8 V. The chip is fabricated in a standard 0.6-μm CMOS process. The die size is 11.25 mm^2. The proposed circuits can be extended to a multi-channel system, with the ADC shared by all channels, as the sensing part of a future closed-loop DBS system for the treatment of intractable epilepsy

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.

NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR function via allosteric modulation are largely unknown. We examine the in vivo effects of GNE-0723, a positive allosteric modulator of GluN2A-subunit-containing NMDARs, on brain network and cognitive functions in mouse models of Dravet syndrome (DS) and Alzheimer's disease (AD). GNE-0723 use dependently potentiates synaptic NMDA receptor currents and reduces brain oscillation power with a predominant effect on low-frequency (12-20 Hz) oscillations. Interestingly, DS and AD mouse models display aberrant low-frequency oscillatory power that is tightly correlated with network hypersynchrony. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in DS and AD mouse models. GluN2A-subunit-containing NMDAR enhancers may have therapeutic benefits in brain disorders with network hypersynchrony and cognitive impairments

Design and Implementation of Complexity Reduced Digital Signal Processors for Low Power Biomedical Applications

Wearable health monitoring systems can provide remote care with supervised, inde-pendent living which are capable of signal sensing, acquisition, local processing and transmission. A generic biopotential signal (such as Electrocardiogram (ECG), and Electroencephalogram (EEG)) processing platform consists of four main functional components. The signals acquired by the electrodes are amplified and preconditioned by the (1) Analog-Front-End (AFE) which are then digitized via the (2) Analog-to-Digital Converter (ADC) for further processing. The local digital signal processing is usually handled by a custom designed (3) Digital Signal Processor (DSP) which is responsible for either anyone or combination of signal processing algorithms such as noise detection, noise/artefact removal, feature extraction, classification and compres-sion. The digitally processed data is then transmitted via the (4) transmitter which is renown as the most power hungry block in the complete platform. All the afore-mentioned components of the wearable systems are required to be designed and fitted into an integrated system where the area and the power requirements are stringent. Therefore, hardware complexity and power dissipation of each functional component are crucial aspects while designing and implementing a wearable monitoring platform. The work undertaken focuses on reducing the hardware complexity of a biosignal DSP and presents low hardware complexity solutions that can be employed in the aforemen-tioned wearable platforms. A typical state-of-the-art system utilizes Sigma Delta (Σ∆) ADCs incorporating a Σ∆ modulator and a decimation filter whereas the state-of-the-art decimation filters employ linear phase Finite-Impulse-Response (FIR) filters with high orders that in-crease the hardware complexity [1–5]. In this thesis, the novel use of minimum phase Infinite-Impulse-Response (IIR) decimators is proposed where the hardware complexity is massively reduced compared to the conventional FIR decimators. In addition, the non-linear phase effects of these filters are also investigated since phase non-linearity may distort the time domain representation of the signal being filtered which is un-desirable effect for biopotential signals especially when the fiducial characteristics carry diagnostic importance. In the case of ECG monitoring systems the effect of the IIR filter phase non-linearity is minimal which does not affect the diagnostic accuracy of the signals. The work undertaken also proposes two methods for reducing the hardware complexity of the popular biosignal processing tool, Discrete Wavelet Transform (DWT). General purpose multipliers are known to be hardware and power hungry in terms of the number of addition operations or their underlying building blocks like full adders or half adders required. Higher number of adders leads to an increase in the power consumption which is directly proportional to the clock frequency, supply voltage, switching activity and the resources utilized. A typical Field-Programmable-Gate-Array’s (FPGA) resources are Look-up Tables (LUTs) whereas a custom Digital Signal Processor’s (DSP) are gate-level cells of standard cell libraries that are used to build adders [6]. One of the proposed methods is the replacement of the hardware and power hungry general pur-pose multipliers and the coefficient memories with reconfigurable multiplier blocks that are composed of simple shift-add networks and multiplexers. This method substantially reduces the resource utilization as well as the power consumption of the system. The second proposed method is the design and implementation of the DWT filter banks using IIR filters which employ less number of arithmetic operations compared to the state-of-the-art FIR wavelets. This reduces the hardware complexity of the analysis filter bank of the DWT and can be employed in applications where the reconstruction is not required. However, the synthesis filter bank for the IIR wavelet transform has a higher computational complexity compared to the conventional FIR wavelet synthesis filter banks since re-indexing of the filtered data sequence is required that can only be achieved via the use of extra registers. Therefore, this led to the proposal of a novel design which replaces the complex IIR based synthesis filter banks with FIR fil-ters which are the approximations of the associated IIR filters. Finally, a comparative study is presented where the hybrid IIR/FIR and FIR/FIR wavelet filter banks are de-ployed in a typical noise reduction scenario using the wavelet thresholding techniques. It is concluded that the proposed hybrid IIR/FIR wavelet filter banks provide better denoising performance, reduced computational complexity and power consumption in comparison to their IIR/IIR and FIR/FIR counterparts

Nano-Watt Modular Integrated Circuits for Wireless Neural Interface.

In this work, a nano-watt modular neural interface circuit is proposed for ECoG neuroprosthetics. The main purposes of this work are threefold: (1) optimizing the power-performance of the neural interface circuits based on ECoG signal characteristics, (2) equipping a stimulation capability, and (3) providing a modular system solution to expand functionality. To achieve these aims, the proposed system introduces the following contributions/innovations: (1) power-noise optimization based on the ECoG signal driven analysis, (2) extreme low-power analog front-ends, (3) Manchester clock-edge modulation clock data recovery, (4) power-efficient data compression, (5) integrated stimulator with fully programmable waveform, (6) wireless signal transmission through skin, and (7) modular expandable design. Towards these challenges and contributions, three different ECoG neural interface systems, ENI-1, ENI-16, and ENI-32, have been designed, fabricated, and tested. The first ENI system(ENI-1) is a one-channel analog front-end and fabricated in a 0.25µm CMOS process with chopper stabilized pseudo open-loop preamplifier and area-efficient SAR ADC. The measured channel power, noise and area are 1.68µW at 2.5V power-supply, 1.69µVrms (NEF=2.43), and 0.0694mm^2, respectively. The fabricated IC is packaged with customized miniaturized package. In-vivo human EEG is successfully measured with the fabricated ENI-1-IC. To demonstrate a system expandability and wireless link, ENI-16 IC is fabricated in 0.25µm CMOS process and has sixteen channels with a push-pull preamplifier, asynchronous SAR ADC, and intra-skin communication(ISCOM) which is a new way of transmitting the signal through skin. The measured channel power, noise and area are 780nW, 4.26µVrms (NEF=5.2), and 2.88mm^2, respectively. With the fabricated ENI-16-IC, in-vivo epidural ECoG from monkey is successfully measured. As a closed-loop system, ENI-32 focuses on optimizing the power performance based on a bio-signal property and integrating stimulator. ENI-32 is fabricated in 0.18µm CMOS process and has thirty-two recording channels and four stimulation channels with a cyclic preamplifier, data compression, asymmetric wireless transceiver (Tx/Rx). The measured channel power, noise and area are 140nW (680nW including ISCOM), 3.26µVrms (NEF=1.6), and 5.76mm^2, respectively. The ENI-32 achieves an order of magnitude power reduction while maintaining the system performance. The proposed nano-watt ENI-32 can be the first practical wireless closed-loop solution with a practically miniaturized implantable device.PhDElectrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/98064/1/schang_1.pd