A system-on-chip digital pH meter for use in a wireless diagnostic capsule

This paper describes the design and implementation of a system-on-chip digital pH meter, for use in a wireless capsule application. The system is organized around an 8-bit microcontroller, designed to be functionally identical to the Motorola 6805. The analog subsystem contains a floating-electrode ISFET, which is fully compatible with a commercial CMOS process. On-chip programmable voltage references and multiplexors permit flexibility with the minimum of external connections. The chip is designed in a modular fashion to facilitate verification and component re-use. The single-chip pH meter can be directly connected to a personal computer, and gives a response of 37 bits/pH, within an operating range of 7 pH units

A Novel Fully Differential Second Generation Current Conveyor and Its Application as a Very High CMRR Instrumentation Amplifier

This paper aims to introduce a novel Fully Differential second generation Current Conveyor (FDCCII) and its application to design a novel Low Power (LP), very high CMRR, and wide bandwidth (BW) Current Mode Instrumentation Amplifier (CMIA). In the proposed application, CMRR, as the most important feature, has been greatly improved by using both common mode feed forward (CMFF) and common mode feedback (CMFB) techniques, which are verified by a perfect circuit analysis. As another unique quality, it neither needs well-matched active blocks nor matched resistors but inherently improves CMRR, BW, and power consumption hence gains an excellent matchless choice for integration. The FDCCII has been designed using 0.18 um TSMC CMOS Technology with ±1.2 V supply voltages. The simulation of the proposed FDCCII and CMIA have been done in HSPICE LEVEL 49. Simulation results for the proposed CMIA are as follow: Voltage CMRR of 216 dB, voltage CMRR BW of 300 Hz. Intrinsic resistance of X-terminals is only 45 Ω and the power dissipation is 383.4 μW.  Most favourably, it shows a constant differential voltage gain BW of 18.1 MHz for variable gains (here ranging from 0 dB to 45.7 dB for example) removing the bottleneck of constant gain-BW product of Voltage mode circuits

Design of a single-chip pH sensor using a conventional 0.6-μm CMOS process

A pH sensor fabricated on a single chip by an unmodified, commercial 0.6-/spl μm CMOS process is presented. The sensor comprises a circuit for making differential measurements between an ion-sensitive field-effect transistor (ISFET) and a reference FET (REFET). The ISFET has a floating-gate structure and uses the silicon nitride passivation layer as a pH-sensitive insulator. As fabricated, it has a large threshold voltage that is postulated to be caused by a trapped charge on the floating gate. Ultraviolet radiation and bulk-substrate biasing is used to permanently modify the threshold voltage so that the ISFET can be used in a battery-operated circuit. A novel post-processing method using a single layer of photoresist is used to define the sensing areas and to provide robust encapsulation for the chip. The complete circuit, operating from a single 3-V supply, provides an output voltage proportional to pH and can be powered down when not required

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC) performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable

A True 1V 1µW Biomedical Front End with Reconfigurable ADC for Self powered Smarter IoT Healthcare Systems

This work proposes an ultralow power highly linear analog front-end (AFE) with an input dynamic range from 200μVpp to 20mVpp. The system consists of a signal conditioning instrumentation amplifier (IA), two programmable gain amplifiers (PGA), a mixed signal automatic gain control (AGC), two sample and hold (S/H), a 10 bit successive approximation register (SAR) analog to digital converter (ADC), and a ΣΔ modulator with 10 bit effective number of bits (ENOB). A highly linear capacitively-coupled IA is achieved by increasing its feedback factor. Moreover, a transconductance (gm) cancellation technique is proposed for achieving a high common mode rejection ratio (CMRR). The conditioned signal is digitized using a SAR ADC for an input range of 200μVpp to 2mVpp, and, an opamp-shared ΣΔ ADC for an input range of 2mVpp to 20mVpp. The selection between the two ADCs is done by the AGC. The full system is designed using 1V supply in UMC 0.18μm CMOS technology. The AFE (IA and the two PGAs) achieves an overall linearity of more than 12 bits, for an input range of 200μVpp to 20mVpp while consuming 300nW with a bandwidth of 0.05 - 250Hz. The power consumption of the SAR ADC is 40nW while operating at a sampling frequency of 1KHz. The ΣΔ ADC consumes 300nW at a sampling frequency of 32KHz with an OSR of 32. The proposed system is intended to be powered by an energy scavenging circuit without compromising its own performance. The system was successfully tested for an ECG signal obtained from PTB database

A Galvanic Isolated Amplifier Based on CMOS Integrated Hall-Effect Sensors

ABSTRACT: A novel galvanic isolated amplifier based on CMOS integrated Hall sensors is presented in this paper. Two serially connected Hall-effect sensors are integrated along with their instrumentation amplifiers using the TSMC 65nm process. A printed-circuit board is employed to validate the proposed isolation amplifier by assembling the chip with chopper modulator, coil driver, miniature coil, variable gain amplifier, and anti-aliasing filter. Because of the miniaturized size of isolation components, this approach can be packaged in chip for industrial applications. This solution replaces the need of bulky/frequency dependent current transformers, complex isolation amplifiers with embedded analog to digital converters, and allows proposed sensors to be used in voltage and current sensing applications. The introduced prototype achieves an input referred offset of 1 mV, 50 dB full-scale signal-to-noise ratio in a 10 kHz bandwidth, and spurious-free dynamic range of 53 dB, while satisfying continuous isolation working voltage of 550 V

Amplifiers in Biomedical Engineering: A Review from Application Perspectives

Continuous monitoring and treatment of various diseases with biomedical technologies and wearable electronics has become significantly important. The healthcare area is an important, evolving field that, among other things, requires electronic and micro-electromechanical technologies. Designed circuits and smart devices can lead to reduced hospitalization time and hospitals equipped with high-quality equipment. Some of these devices can also be implanted inside the body. Recently, various implanted electronic devices for monitoring and diagnosing diseases have been presented. These instruments require communication links through wireless technologies. In the transmitters of these devices, power amplifiers are the most important components and their performance plays important roles. This paper is devoted to collecting and providing a comprehensive review on the various designed implanted amplifiers for advanced biomedical applications. The reported amplifiers vary with respect to the class/type of amplifier, implemented CMOS technology, frequency band, output power, and the overall efficiency of the designs. The purpose of the authors is to provide a general view of the available solutions, and any researcher can obtain suitable circuit designs that can be selected for their problem by reading this survey