Sarcoma of the Vagina.

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Pathological studies on the fowl with special reference to neoplasia

The following 25 papers represent studies on a number of different aspects of disease in the domesticated fowl. As the majority are on the subject of neoplasia, they will be summarised first. They are divisible into studies from the aspects of com- parative pathology (Nos. 1, 2, 3, 6, 13); the classification of the leucoses (Nos. 9, 12, 18); the tumour viruses (Nos. 7, 8); chemical induction experiments (Nos. 10, 11); enzyme histochemistry (No.5.); and endocrine studies (Nos. 14, 15, 16, 17).In addition, there are five papers of joint authorship on miscellaneous subjects. The earlier papers are based on work done while the author was in charge of the Poultry Diseases Department at the (then) Royal (Dick) Veterinary College, whilst the later papers are the result of work undertaken subsequent to a9pointment as Research Officer in the British Empire Cancer Campaign Unit at the A.R.C. Poultry Research Centre, Edinburgh. The paper on Bangkok Haemorrhagic Disease (No.20) is based on material collected while working in an advisory capacity to the Government of Thailand, for the Food and Agricultural Organisation of the United Nations.1. Myelocytoma in the domestic fowl. 1942. Vet. J. 96 (2). || 2. Embryonal nephroma in the domestic fowl. 1942. Vet. J. 98 (5). || 3. Histiocytic and Fibroplastic Sarcoma Nixed-cell Sarcoma) in the domestic fowl. 1943. J. Comp. Path. Therap. 53 (4). || 4. Neoplastic disease of the fowl, with special reference to its history, incidence, and seasonal variation. 1945. J. Comp.Path. Therap. 55 (4). || 5. The intracellular localisation of B- Glucuronidase. 1950. Brit. J. 11 exp. Path. 30, 548. || 6. Some unusual gonadal tumours of the fowl. 1951. Brit. J. Cancer, 5 (1), 69. || 7. The occurrence of blood filaments (pseudospirochaetes) in certain neoplastic conditions. 1952. Brit. Vet. J. 108 (6), 191. || 8. the "Eclipse Phase" Virus Leukaemia of the Chicken. 1954. Brit. J. Cancer, 8, 737. || 9. Avian Leucosis: A Plea for Clarification. 1954. Off. Rep. Xth World's Poult.Congr. Section C. p. 193. || 10. Induction of Multiple Primary Tumours in Fowls with 2- Acetamidofluorene. 1954. Brit. J. Cancer, 9, 163. || 11. An Investigation of the Hepatotoxic Effects in the Fowl of Ragwort (Senecio jacobaea Linn.) with special reference to the Induction of Liver Tumours with Seneciphylline. 1956. Proc. Roy.Soc. Edin.B. 66, 111. || 12. Leucosis and Fowl Paralysis Compared and Contrasted. 1956. Vet. 37d6a.68, 527. || 13. Two cases of Rhabdomyosarcoma in the Fowl. 1956. Brit.J.Cancer,l0, 700. || 14. Studies on the influence of sex hormones on the avian liver. I. Sexual differences in Avian Liver Clearance Curves. 1957. J. Endocrino1.15, 339. || 15. Studies on the influence of sex hormones on the avian liver. II. Acute liver damage in the male Fowl, and the protective effect of oestrogen, as determined by a liver function test. 1957. J. Endocrinol. 15, 346. || 16. Studies on the influence of sex hormones on the avian liver. III. Oestrogen - induced Regeneration of the Chronically Damaged Liver. 1957. J.Endocrinol. 15, 351. || 17. The Detection and Identification of Avian Gonadal Tumours by means of- a Liver Clearance Test. 1958. In Press. || 18. Recent Investigations on Avian Leucosis and Fowl Paralysis. 1958. Vet. Rec. 70, 64. || 19. An Infectious Enteritis of Young Turkeys associated with Cochlosoma sp. 1945. Vet. J. 101. (12) || 20. Bangkok Haemorrhagic Disease. An Unusual Condition associated with an organism of uncertain Taxonomy. 1953. J. Path. Bact. 68 (2), 423. || 21. (with SLOAN, J. E. N.) A possible new Species of Trematode Parasite in the kidneys of the King Penguin (Aptenodytes longirostris). 1943 Vet. J. 99 (2). || 22. (with ROBERTSON, A. & GRAVES, D.N.) Experimental Zinc Phosphide Poisoning in Fowls. 1945. J. Comp. Path. Therap. 55 (4). || 23. (with LEVVY, G.A. & KERR, L.M.H.) p- Glucuronidase and Cell Proliferation. 1948. Biochem. J. 42 (3),462. || 24. (with KERR, L.1. H. & LEVVY, G. A.) p- Glucuronidase as an Index to Growth in the Uterus and Other Organs. 1949. Biochem. J. 44 (4) : 487. || 25. (with KERR, L.M.H & LEVVY, G.A.) Further Observations on Changes in p- Glucuronidase Activity in the Mouse. 1950. Biochem. J. 46 (3), 278

Pathological studies on neoplasms of dogs in South Africa

In 1956 studies on neoplasms of dogs were commenced at the Liesbeek Clinic. De Kock (1957a) stressed the importance of these investigations, especially in respect of their comparative value to the study of neoplasms in man. Suitable forms were circulated amongst veterinarians and these were based on the observations published in a number of overseas journals. In such a survey of tumours in dogs in South Africa, special attention should be paid to geographical, breed, age, sex and site incidences, as well as to clinical data. The importance of careful autopsies was stressed for a proper reorientation of the site and nature of the tumour and the problem of metastasis, and the possible occurrence of multiple primary tumours. It entailed the proper selection of specimens and suitable smears for microscopical studies in order to arrive at a histological diagnosis. Large numbers of tumours in dogs have been investigated and described, e.g. by Feldman (1932), Jackson (1936), Innes (1943), Mulligan (1949), and others. Head (1959) and Cotchin (1959) have so far investigated close on 9,000 tumours in dogs. Jackson indicates that a full history of the subject, and a careful description of the specimen in situ are of great importance to the pathologist. Innes maintains that unless meticulous autopsies with histological examination are made on a long series of animals, many tumours may evade recognition or accurate diagnosis. The effective classification of neoplasms, according to Jackson, is one of the most subtle problems of pathology. There is a multiplication of nomenclature on the basis of variation of morphological appearance. He maintains that proliferative processes may be variously classed as nodular hyperplasia or as an adenoma in such organs as the liver, spleen, prostate, etc., and difficulties also arise in deciding whether one is dealing with a benign or a malignant tumour. Further comment on certain aspects of the pathology of tumours raised in the literature will be referred to when the results of the investigations at the Liesbeek Clinic are considered.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.The National Cancer Association of South Afric

Sclerosing Epithelioid Fibrosarcoma: Case Presentation and a Systematic Review

In sclerosing epithelioid fibrosarcoma (SEF), a rare variant of low-grade fibrosarcoma, treatment results and therapeutic options are poorly characterized. We systematically analyzed the data of all 89 patients (43 female, 46 male; mean age, 47years [range, 14-87years]) reported in the literature concerning clinical presentation, histopathology, differential diagnosis, treatment, survival rates, and prognosis, and we present an additional case. Information detailing treatment, disease control, and followup was available in 60 (67%), 75 (84%), and 68 patients (76%), respectively. Case history was variable with one-third of patients reporting a painful, enlarging mass. Ten patients (13%) presented with metastases, 23 (31%) had metastases develop after diagnosis, and 28 (37%) had local recurrence. Low cellularity, mild pleomorphy, and sclerotic hyaline matrix of SEF suggest a benign clinical behavior, and cell morphology allows for the wide differential diagnosis of benign, pseudosarcomatous, and malignant proliferations. In addition to surgery, 11 patients (15%) had chemotherapy, 22 (29%) had postoperative radiation therapy, and three (4%) had a combination of both. Twenty-three patients (34%) died from their disease after a mean of 46months, 24 (35%) were alive with disease, and 20 (31%) were alive without evidence of disease. Patients with SEF of the head and neck had the worst prognosis. Level of Evidence: Level III, prognostic study. See the Guidelines for Authors for a complete description of levels of evidenc

Giant fibroepithelial polyp of vulva with fibroid uterus with primary lymphedema (Meige disease/lymphedema praecox): a rare case report

Fibroepithelial polyps or FSPs develop in the reproductive years of young to middle-aged women. They primarily affect the vagina, and their occurrence in the vulva is less common. Giant FSP are very rare. We present a case of a patient with giant FSP of the vulva with unilateral lymphedema. A forty year old patient presented with history of mild, dull, aching, continuous pain in lower abdomen. After her first delivery, she had developed pruritis over vulva followed by appearance of a growth. A non-tender, mobile warty growth was found on the examination of vulva, and it involved the mons pubis, clitoris and left labia minora and major. Dermatological consultation made a preliminary diagnosis of nevoid growth vulva. Operative findings from exploratory laparotomy confirmed that uterus had enlarged to 28 weeks size. The diagnosis of fibroepithelial polyp was confirmed by histopathological examination. A common pathogenetic background of lymphedematous FSPs is persistent lymph stasis, along with consequent injury of microcirculation and stromal hyperplasia. The role of hormonal factors in the development of these lesions in also supported by the Estrogen and progesterone receptor positivity. The association of FSPs with unilateral lymphedema, as in our patient, is very rare. This case provides some evidence that chronic lymph stasis can lead to microcirculation injury which further lead to stromal hyperplasia

Low-grade sarcoma in classical seminoma - the first case reported

A 30-year-old male with no previous history of neoplastic disease presented with a 5 cm large testicular tumor. Routine histopathological examination and immunohistochemical investigation showed a classical seminoma with a contiguous 8 mm large nodule. The nodule was separated from the tunica albuginea by tubuli semi-niferi showing intratesticular germ cell neoplasi not otherwise specified (NOS). The nodule was composed of spindle cells with low-grade nuclear atypia, nuclear and cytoplasmic S100 protein immunoreactivity in 15% of the cells and a proliferative activity of up to 20%. No other germ cell tumor components were found. To the best of our knowledge, we herein present the first tumor of a pure classical seminoma with an associated low-grade sarcomatous component.Natl Univ Hlth Syst, Dept Pathol, Singapore 119074, SingaporeCharles Univ Prague, Med Fac Hosp, Sikls Dept Pathol, Plzen, Czech RepublicFed Univ Sao Paolo, EPM UNIFESP, Dept Pathol, Sao Paulo, BrazilBiopticka Lab Sro, Plzen, Czech RepublicFed Univ Sao Paolo, EPM UNIFESP, Dept Pathol, Sao Paulo, BrazilWeb of Scienc

Krukenberg tumor in a young female arising from a primary adenocarcinoma of stomach: a case report

Krukenberg tumor is a malignancy of ovary that metastasizes from a primary site. Krukenberg tumors are uncommon and account for less than 2% of all ovarian tumors. It is usually a bilateral involvement of ovaries from the metastatic deposit from adenocarcinoma of the stomach. Krukenberg tumors mostly occur after 40 years. Metastatic ovarian tumors in young age are very rare. Here, we reported a very rare case of bilateral Krukenberg tumors of the ovaries arising from a primary adenocarcinoma of the stomach in a 20 year old Indian female

Unusual bilateral ovarian metastases from ileal gastrointestinal stromal tumor (GIST): a case report

open9noBACKGROUND: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare. CASE PRESENTATION: A 50 years-old woman was found to have a pelvic mass on transvaginal ultrasound (TV-US) and computed tomography (CT)-scan, considered as a right ovarian mass. The patient underwent surgical abdominal exploration that showed an ileal mass, a normal right ovary and an irregular and vascularized surface of the left ovary. A segmental ileal resection and an ileal anastomosis were performed. Frozen section showed a GIST and surgery was completed with hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, peritoneal washing and Burch procedure. The histological examination confirmed an ileal GIST with ovarian metastases, harboring in both sites of disease a KIT exon 11 deletion. CONCLUSIONS: Ovarian localizations, as far as rare, can be a clinical finding in case of ileal GIST patients, and both gynecologists, pathologists and medical oncologists should be able to recognize them.openDe Leo A, Nannini M, Dondi G, Santini D, Urbini M, Gruppioni E, De Iaco P, Perrone AM, Pantaleo MA.De Leo A, Nannini M, Dondi G, Santini D, Urbini M, Gruppioni E, De Iaco P, Perrone AM, Pantaleo MA