On large-scale probabilistic and statistical data analysis

In this manuscript we develop and apply modern algorithmic data reduction techniques to tackle scalability issues and enable statistical data analysis of massive data sets. Our algorithms follow a general scheme, where a reduction technique is applied to the large-scale data to obtain a small summary of sublinear size to which a classical algorithm is applied. The techniques for obtaining these summaries depend on the problem that we want to solve. The size of the summaries is usually parametrized by an approximation parameter, expressing the trade-off between efficiency and accuracy. In some cases the data can be reduced to a size that has no or only negligible dependency on the initial number of data items. However, for other problems it turns out that sublinear summaries do not exist in the worst case. In such situations, we exploit statistical or geometric relaxations to obtain useful sublinear summaries under certain mildness assumptions. We present, in particular, the data reduction methods called coresets and subspace embeddings, and several algorithmic techniques to construct these via random projections and sampling

The potential advantages and drawbacks of pencil beam scanning proton therapy in the management of paediatric, teenage and young adult malignancies

Pencil beam scanning (PBS) proton therapy is a new radiation modality which is increasingly used for childhood teenage and young adult malignancies due to its ability to minimise dose to surrounding organs, which in turn translates to reduced late toxicity. However, its dosimetry is extremely sensitive to anatomical changes, density changes and motion. Research on its benefits, drawbacks, clinical efficacy and side effects is therefore required for clinical teams to understand the best way and situation to use this modality in the clinic. Neuroblastoma is a childhood cancer most commonly arising within the abdomen. Radiotherapy to the primary tumour bed is part of the multimodality management for high risk patients. This collection of work investigates the benefits and detriments of PBS in abdominal neuroblastoma alongside the associated dosimetric impact from uncertainties such as set up variation, gastrointestinal tract density variability and intra-field motion. Methods of managing the uncertainties are also examined. Teenage and young adults are a unique and challenging group of patients with complex psychosocial needs. The efficacy and late effects of PBS in this age group with brain and skull base tumours is detailed with analysis of their employment status during survivorship

The Pleistocene of the Mendip region : Aspects of the absolute dated, faunal and sediment records.

Available from British Library Document Supply Centre- DSC:DX81620 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Energy: A continuing bibliography with indexes

This bibliography lists 1096 reports, articles, and other documents introduced into the NASA Scientific and Technical Information System from April 1, 1979 through June 30, 1979

Energy: A continuing bibliography with indexes, issue 20

A bibliography is presented which lists 1250 reports, articles, and other documents introduced into the NASA Scientific and Technical Information System from October 1, 1978 through December 31, 1978